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公开(公告)号:US10782190B1
公开(公告)日:2020-09-22
申请号:US16221270
申请日:2018-12-14
Applicant: University of Rhode Island Board of Trustees
Inventor: Otto J. Gregory , Kevin Rivera , Matthew Thomas Ricci
Abstract: A resistance temperature detector (RTD) that uses a ceramic matrix composite (CMC), such as a silicon carbide fiber-reinforced silicon carbide matrix, as an active temperature sensing element, which can operate at temperatures greater than 1000° C. or even 1600° C. Conductive indium tin oxide or a single elemental metal such as platinum is deposited on a dielectric or insulating layer such as mullite or an environmental barrier coating (EBC) on the substrate. Openings in the layer allow etching of the CMC surface in order to make high quality ohmic contacts with the conductive material, either directly or through a silicide diffusion barrier such as ITO. The RTD can measure both temperature and strain of the CMC. The use of an EBC, which typically is deposited on the CMC by the manufacturer, as the insulating or dielectric layer can be extended to other devices such as strain gages and thermocouples that use the CMC as a sensing element. The EBC can be masked and etched to form the openings. A conductive EBC can be used as the silicide diffusion barrier.
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公开(公告)号:US12282052B2
公开(公告)日:2025-04-22
申请号:US17795997
申请日:2021-01-29
Applicant: University of Rhode Island Board of Trustees
Inventor: Ken Qing Yang , Tao Wei , Zhenyu Xu
Abstract: Method and apparatus for detecting in impedance change in a transmission line, such as a line in a computer bus. A CMOS-compatible time domain reflectometer circuit comprising a comparator is embedded in one or more chips and connected to the transmission line. The circuit measures the impedance inhomogeneity pattern (IIP) of the transmission line prior to use, and then repeatedly measures the HP during operation of the transmission line to detect a change in IIP, without Interfering with data transfer through the transmission line. The present invention can detect and locate wire-tapping magnetic probing or snooping, and Trojan and cold boot attacks on interconnecting buses between computer chips or integrated circuits in a computer system, such as on external memory buses.
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公开(公告)号:US20240342296A1
公开(公告)日:2024-10-17
申请号:US18608699
申请日:2024-03-18
Inventor: Yana K. RESHETNYAK , Oleg A. ANDREEV , Anna MOSHNIKOVA , Donald M. ENGELMAN
IPC: A61K47/64 , A61K9/00 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61P35/00
CPC classification number: A61K47/6425 , A61K9/0014 , A61K9/0034 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61K47/6415 , A61P35/00
Abstract: The invention features a composition comprising a potent cytotoxic compound and a pHILIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHILIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
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公开(公告)号:US11851644B2
公开(公告)日:2023-12-26
申请号:US16866265
申请日:2020-05-04
Applicant: University of Rhode Island Board of Trustees
Inventor: David R. Nelson , Jason LaPorte , David C Rowley , Marta Gomez-Chiarri
IPC: C12N1/20 , A61K35/741
CPC classification number: C12N1/20 , A61K35/741 , C12N2500/05 , C12N2500/32 , C12N2500/74
Abstract: The invention provides a method and related compositions for preparing an effective probiotic bacteria formulation that can be stored, transported and used for protecting a variety of marine organisms against infection by potential pathogens.
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公开(公告)号:US11779662B2
公开(公告)日:2023-10-10
申请号:US15713324
申请日:2017-09-22
Inventor: Yana K. Reshetnyak , Oleg A. Andreev , Donald M. Engelman
IPC: A61K49/00 , C07K19/00 , C07K14/00 , A61B5/00 , G01N33/58 , A61K49/04 , A61K49/22 , C09B69/10 , C09K11/06
CPC classification number: A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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36.
公开(公告)号:US11738096B2
公开(公告)日:2023-08-29
申请号:US16334734
申请日:2017-09-22
Inventor: Yana K. Reshetnyak , Oleg A. Andreev , Donald M. Engelman
IPC: A61K49/00 , C07K19/00 , C07K14/00 , A61B5/00 , G01N33/58 , A61K49/22 , C09B69/10 , C09K11/06 , A61K49/04
CPC classification number: A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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公开(公告)号:US11703471B1
公开(公告)日:2023-07-18
申请号:US16724068
申请日:2019-12-20
Applicant: University of Rhode Island Board of Trustees
Inventor: Otto J. Gregory , Peter Ricci, III , Andrew Rossi
CPC classification number: G01N25/36 , B01J23/52 , B01J35/023 , G01N25/34
Abstract: Methods and apparatuses for highly sensitive detection of analytes using redox reactions. A library of heat reactions of analytes of interest with a variety of catalysts at a variety of temperatures is prepared. An array of sensors with low thermal mass heating elements is prepared, depositing the same or different catalysts, such as metal oxide catalysts that have multiple oxidation states, on each heating element. The low thermal mass heating elements are preferably not in thermal contact with a substrate, or a low mass substrate is used. The array is exposed to a sample at various temperatures. The sign and magnitude of the heat effect of the redox reaction of compounds in the sample or their decomposition products with each catalyst is measured and compared with the library. The catalysts and temperatures are chosen so that the desired analytes have a unique pattern of heat effect signs and magnitudes when reacted with those catalysts at those temperatures. The resulting detector is highly selective and sensitive to the analytes of interest.
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公开(公告)号:US20220332770A1
公开(公告)日:2022-10-20
申请号:US17719015
申请日:2022-04-12
Applicant: University of Rhode Island Board of Trustees
Inventor: Xinyuan CHEN , Yiwen ZHAO
IPC: C07K14/255 , C07K14/005 , A61K39/39 , A61K39/145 , A61P31/16 , C12N7/00 , A61K39/00 , A61P37/04 , A61P25/34
Abstract: The invention provides a novel fusion protein between flagellin (or portions thereof) and a polypeptide that can form a virus-like particle (VLP) (e.g., hepatitis b core (HBc) protein or portions thereof), where the fusion protein continues to form a VLP in an aqueous environment. The VLPs based on such fusion proteins (e.g., FH VLPs) provide a versatile, highly immunogenic, and safe vaccine carrier capable of displaying or associating a variety of vaccine antigens on VLP surface to elicit potent humoral and cellular immune responses.
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39.
公开(公告)号:US20220285732A1
公开(公告)日:2022-09-08
申请号:US17685076
申请日:2022-03-02
Applicant: University of Rhode Island Board of Trustees , GOTION, INC.
Inventor: Brett LUCHT , Jongjung KIM , Venkata A.K. ADIRAJU , Jennifer HOFFMANN , Martin PAYNE
IPC: H01M10/0567 , H01M10/0525 , H01M4/583 , H01M4/505 , H01M10/0568
Abstract: This work investigates the beneficial roles of lithium bis(trimethylsilyl) phosphate (LiTMSP) which may act as a novel bifunctional additive for lithium ion batteries, in particular, LiNi0.5Mn1.5O4 (LNMO)/graphite cells. The cycle performance of LNMO/graphite cells is significantly improved with incorporation of LiTMSP. Trimethylsilyl functional group therein can react with HF generated through hydrolysis of LiPF6 by residual water in electrolyte solution, followed by a decrease in the concentration of metal ions dissolution from the electrode. The generation of superior passivating surface film derived by LiTMSP on graphite electrode, suppressing further electrolyte reductive decomposition and deterioration/reformation caused by migrated metal ions, is confirmed. Furthermore, LiTMSP derived surface film is likely to have better lithium ions conductivity with a decrease in resistance of the graphite electrode, improving rate performance of cells. The HF scavenging and film-forming effects of LTMPS are responsible for the less polarization of cells enabling to improve cycle performance.
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公开(公告)号:US20220144396A1
公开(公告)日:2022-05-12
申请号:US17515933
申请日:2021-11-01
Applicant: University of Rhode Island Board of Trustees
Inventor: Dillon Fontaine , Arun Shukla
IPC: B63G8/04
Abstract: Structures designed to mitigate implosion pressure spikes through the use of an external sacrificial confining structure. Such improved structures can, in some embodiments, completely surround the existing structures that are at a high risk of imploding. The improved structures can slow the rate at which the surrounding fluid media volume is consumed by providing resistance to flow into the enclosure.
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