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    Unsymmetrical cyanine dimer compounds and their application
    31.
    发明申请
    Unsymmetrical cyanine dimer compounds and their application 审中-公开
    不对称花青二聚体化合物及其应用

    公开(公告)号：US20050074796A1

    公开(公告)日：2005-04-07

    申请号：US10911423

    申请日：2004-08-02

    Applicant: Stephen Yue ,  Ching-Ying Cheung

    Inventor： Stephen Yue ,  Ching-Ying Cheung

    IPC: C07D215/18 ,  C07H21/02 ,  C09B23/02 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  C09B23/0016 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B55/006 ,  Y10S436/80 ,  C12Q2563/173

    Abstract: Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.

    Abstract translation: 本发明的实施方案提供了用于检测样品中核酸的方法和核酸报告分子。 核酸报告分子包含两个不对称的花青单体部分，其可以相同或不同，其通过包含至少一个芳族，杂芳族，环状或杂环部分的连接体共价连接，该部分包含3-20个非氢原子，所述非氢原子选自 由O，N，S，P和C组成的组。接头可以是刚性的，相对柔性的或其某种程度的。 不对称花青单体部分包含取代或未取代的苯并唑鎓部分和通过单甲基，三甲基或五甲氧基的次甲基桥连接的取代或未取代的吡啶鎓或喹啉鎓部分。 连接体通过连接到单体部分的吡啶鎓或喹啉鎓部分而形成花青二聚体化合物。 本发明的核酸报告分子可用于形成核酸 - 报道分子复合物并检测核酸。 特别地，具有刚性连接体和具有单甲基桥的单体部分的本发明的核酸报告分子在DNA存在下可用于检测RNA。

    Distributed health check for global server load balancing
    32.
    发明授权
    Distributed health check for global server load balancing 有权
    分布式运行状况检查全局服务器负载均衡

    公开(公告)号：US09130954B2

    公开(公告)日：2015-09-08

    申请号：US10305823

    申请日：2002-11-27

    Applicant: Prajakta S. Joshi ,  David Chun Ying Cheung

    Inventor： Prajakta S. Joshi ,  David Chun Ying Cheung

    IPC: H04L29/08

    CPC classification number: H04L67/1008 ,  H04L67/1002 ,  H04L67/1012 ,  H04L67/1021

    Abstract: A global server load-balancing (GSLB) switch serves as a proxy to an authoritative DNS and communicates with numerous site switches that are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. This operational information includes health check information that is remotely obtained in a distributed manner from remote metric agents at the site switches. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics, including the health check metric that evaluates these IP addresses based on the health check information communicated to the GSLB switch in a distributed manner by the distributed health check site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.

    Abstract translation: 全局服务器负载平衡（GSLB）交换机用作授权DNS的代理，并与多个站点交换机进行通信，这些站点交换机与服务于特定应用程序的主机服务器相连。 GSLB交换机从站点交换机接收关于站点交换机附近的主机服务器的操作信息。 该操作信息包括以现场交换机的远程度量代理以分布式方式远程获取的健康检查信息。 当客户端程序请求解析主机名时，作为权威DNS的代理的GSLB交换机返回主机名的一个或多个有序IP地址。 IP地址使用度量进行排序，包括基于通过分布式健康检查站点交换机以分布式方式传送到GSLB交换机的运行状况检查信息来评估这些IP地址的健康检查指标。 在一个实例中，GSLB开关将地址视为“最佳”位于列表的顶部。

    Substituted anthraquinone dyes for cellular stains and enzyme detection
    33.
    发明授权
    Substituted anthraquinone dyes for cellular stains and enzyme detection 有权
    取代的蒽醌染料用于细胞染色和酶检测

    公开(公告)号：US08790892B2

    公开(公告)日：2014-07-29

    申请号：US13439821

    申请日：2012-04-04

    Applicant: Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Lori Michelle Roberts

    Inventor： Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Lori Michelle Roberts

    IPC: G01N1/30

    CPC classification number: C09B1/516 ,  A61K49/0052 ,  C09B1/501 ,  C09B1/51 ,  C09B1/5155 ,  G01N1/30 ,  G01N21/6428

    Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

    Abstract translation: 本发明公开了可用作细胞污渍的新的取代的蒽醌染料。 在本发明的某些方面，核染料可用于染色死细胞或固定细胞的细胞核。 本发明的另一方面涉及包含酶底物部分的取代的蒽醌染料，其可由酶转化或切割，使得底物部分的转化或切割导致染料的官能度或光谱性质的可检测变化。

    Connection rate limiting for server load balancing and transparent cache switching
    34.
    发明授权
    Connection rate limiting for server load balancing and transparent cache switching 有权
    服务器负载平衡和透明缓存切换的连接速率限制

    公开(公告)号：US08572228B2

    公开(公告)日：2013-10-29

    申请号：US12785423

    申请日：2010-05-21

    Applicant: Ronald W. Szeto ,  David Chun Ying Cheung ,  Rajkumar Jalan

    Inventor： Ronald W. Szeto ,  David Chun Ying Cheung ,  Rajkumar Jalan

    IPC: G06F15/173

    CPC classification number: H04L67/1002 ,  H04L63/0218 ,  H04L63/1458 ,  H04L67/1031 ,  H04L67/1036 ,  H04L67/2842

    Abstract: Each service in a computer network may have a connection rate limit. The number of new connections per time period may be limited by using a series of rules. In a specific embodiment of the present invention, a counter is increased each time a server is selected to handle a connection request. For each service, connections coming in are tracked. Therefore, the source of connection-request packets need not be examined. Only the destination service is important. This saves significant time in the examination of the incoming requests. Each service may have its own set of rules to best handle the new traffic for its particular situation. For server load balancing, a reset may be sent to the source address of the new connection request. For transparent cache switching, the connection request may be forwarded to the Internet.

    Abstract translation: 计算机网络中的每个服务可能具有连接速率限制。 每个时间段的新连接数可以通过使用一系列规则来限制。 在本发明的具体实施例中，每当选择服务器来处理连接请求时，增加计数器。 对于每个服务，跟踪进入的连接。 因此，不需要检查连接请求数据包的来源。 只有目的地服务很重要。 这样可以节省大量时间来检查传入的请求。 每个服务可能有自己的一套规则，以便为特定情况最好地处理新的流量。 对于服务器负载平衡，可以将重置发送到新连接请求的源地址。 对于透明缓存切换，连接请求可以被转发到因特网。

    Global server load balancing
    36.
    发明授权
    Global server load balancing 有权
    全局服务器负载均衡

    公开(公告)号：US08024441B2

    公开(公告)日：2011-09-20

    申请号：US11707697

    申请日：2007-02-16

    Applicant: Sunanda Lakshmi Kommula ,  Ivy Pei-Shan Hsu ,  Rajkumar Jalan ,  David Chun Ying Cheung

    Inventor： Sunanda Lakshmi Kommula ,  Ivy Pei-Shan Hsu ,  Rajkumar Jalan ,  David Chun Ying Cheung

    IPC: G06F15/173

    CPC classification number: H04L67/1002 ,  H04L67/1008 ,  H04L67/1012 ,  H04L67/1021

    Abstract: A global server load-balancing (GSLB) switch serves as a proxy to an authoritative DNS and communicates with numerous site switches that are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics that include the information collected from the site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.

    Abstract translation: 全局服务器负载平衡（GSLB）交换机用作授权DNS的代理，并与多个站点交换机进行通信，这些站点交换机与服务于特定应用程序的主机服务器相连。 GSLB交换机从站点交换机接收关于站点交换机附近的主机服务器的操作信息。 当客户端程序请求解析主机名时，作为权威DNS的代理的GSLB交换机返回主机名的一个或多个有序IP地址。 IP地址使用包含从站点交换机收集的信息的度量来排序。 在一个实例中，GSLB开关将地址视为“最佳”位于列表的顶部。

    UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION
    38.
    发明申请
    UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION 有权
    不对称氰基二异氰酸酯化合物及其应用

    公开(公告)号：US20110143337A1

    公开(公告)日：2011-06-16

    申请号：US13017242

    申请日：2011-01-31

    Applicant: Stephen YUE ,  Ching-Ying Cheung

    Inventor： Stephen YUE ,  Ching-Ying Cheung

    IPC: C12Q1/70 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  Y10S436/80 ,  C12Q2563/173

    Abstract: Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.

    Abstract translation: 本发明的实施方案提供了用于检测样品中核酸的方法和核酸报告分子。 核酸报告分子包含两个不对称的花青单体部分，其可以相同或不同，其通过包含至少一个芳族，杂芳族，环状或杂环部分的连接体共价连接，该部分包含3-20个非氢原子，所述非氢原子选自 由O，N，S，P和C组成的组。接头可以是刚性的，相对柔性的或其某种程度的。 不对称花青单体部分包含取代或未取代的苯并唑鎓部分和通过单甲基，三甲基或五甲氧基的次甲基桥连接的取代或未取代的吡啶鎓或喹啉鎓部分。 连接体通过连接到单体部分的吡啶鎓或喹啉鎓部分而形成花青二聚体化合物。 本发明的核酸报告分子可用于形成核酸 - 报道分子复合物并检测核酸。 特别地，具有刚性连接体和具有单甲基桥的单体部分的本发明的核酸报告分子在DNA存在下可用于检测RNA。

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