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公开(公告)号：US07754235B2
公开(公告)日：2010-07-13
申请号：US11410003
申请日：2006-04-25
CPC分类号： C09J133/14 , Y10T428/2891 , Y10T428/31935
摘要： The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.
摘要翻译： 本发明提供能够提供粘合剂层的粘合剂，粘合剂层显示出降低的粘性，减少的内聚破坏等。 含有通过使包含（甲基）丙烯酸烷基酯作为主要成分的单体和具有羟基和/或羧基的乙烯基单体共聚而得到的平均分子半径不小于70nm的共聚物 通过多角度激光散射法测量。
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公开(公告)号：US07749586B2
公开(公告)日：2010-07-06
申请号：US10140053
申请日：2002-05-08
申请人： Hitoshi Akemi , Kazuhiro Higashio
发明人： Hitoshi Akemi , Kazuhiro Higashio
CPC分类号： C09J7/403 , C09J7/20 , C09J2205/31 , Y10T156/1064 , Y10T156/1082 , Y10T428/14 , Y10T428/1476 , Y10T428/149 , Y10T428/1495 , Y10T428/15
摘要： An adhering member comprises an adhesive layer 2 of a thickness R formed on one surface of a backing 1, and a liner 3 of a thickness T laminated on the adhesive layer, and has a half-cut formed in the liner for making handleability satisfactory while preventing seepage of contents. The adhering member excellent in handleability and stability is obtained by providing, for example, the half-cut 4 having a rectangular or inverted triangular sectional shape, a groove width of 200 μm or less, and a groove depth of more than 14T/15 but less than (T+R).
摘要翻译： 粘合部件包括形成在背衬1的一个表面上的厚度R的粘合剂层2和层压在粘合剂层上的厚度为T的衬垫3，并且具有形成在衬里中的半切口，以使操作性令人满意，而 防止内容物渗透。 通过提供例如具有矩形或倒三角形截面形状，槽宽度为200μm以下，槽深度大于14T / 15的半切割4，可以获得可操作性和稳定性优异的粘合部件，但是 小于（T + R）。
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公开(公告)号：US20080149277A1
公开(公告)日：2008-06-26
申请号：US12000742
申请日：2007-12-17
IPC分类号： B32B37/12
CPC分类号： A61F13/02 , A61F13/00991 , A61F2013/0296 , A61K9/7061 , Y10T156/1724 , Y10T156/1798
摘要： A manufacturing apparatus of a transdermal absorption preparation, comprising an adhesive sheet supplying part A to feed out a band-like first adhesive sheet 3 into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part B to apply a given amount of a drug liquid to an adhesive face 2b, and a traveling section C for impregnation which is set in the runway after the drug liquid application part B, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.
摘要翻译： 一种透皮吸收制剂的制造装置，其特征在于，包括粘合片供给部A将带状的第一粘合片3送入到跑道中，所述粘合片至少具有粘合剂层，所述粘合剂层包含粘合剂和与 粘合剂，将药液施加给粘合面2b的药液施加部B和在药液施加部B之后设置在跑道中的浸渍行进部C，在该过程中粘合剂 将片材运行所需的时间，使所施加的药液浸没到粘合剂层中，而不会使粘合剂层的药物液体涂覆面与其它部件接触。
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公开(公告)号：US20060246281A1
公开(公告)日：2006-11-02
申请号：US11410003
申请日：2006-04-25
CPC分类号： C09J133/14 , Y10T428/2891 , Y10T428/31935
摘要： The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.
摘要翻译： 本发明提供能够提供粘合剂层的粘合剂，粘合剂层显示出降低的粘性，减少的内聚破坏等。 含有通过使包含（甲基）丙烯酸烷基酯作为主要成分的单体和具有羟基和/或羧基的乙烯基单体共聚而得到的平均分子半径不小于70nm的共聚物 通过多角度激光散射法测量。
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公开(公告)号：US08327903B2
公开(公告)日：2012-12-11
申请号：US12000742
申请日：2007-12-17
IPC分类号： B29C43/30
CPC分类号： A61F13/02 , A61F13/00991 , A61F2013/0296 , A61K9/7061 , Y10T156/1724 , Y10T156/1798
摘要： A manufacturing apparatus of a transdermal absorption preparation includes an adhesive sheet supplying part to feed out a band-like first adhesive sheet into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part to apply a given amount of a drug liquid to an adhesive face, and a traveling section for impregnation which is set in the runway after the drug liquid application part, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.
摘要翻译： 透皮吸收制剂的制造装置包括将带状第一粘合片输送到跑道中的粘合片供给部，其中，所述粘合片至少具有粘合剂层和与所述粘合剂相容的液体成分， 药液施加部，将给定量的药液施加到粘合面上;以及浸渍移动部，其设置在药液施加部之后的跑道中，粘贴片的运行期间为 将所施加的药液浸入粘合剂层中，而不与粘合剂层的药液涂布面与其它构件接触。
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公开(公告)号：US5876745A
公开(公告)日：1999-03-02
申请号：US742487
申请日：1997-01-23
CPC分类号： A61K9/7053 , A61F13/0233 , A61F13/0243 , A61F13/0253 , A61K9/7061 , A61L15/58 , A61F2013/00153 , A61F2013/00234 , A61F2013/00608 , A61F2013/00663 , A61F2013/0071 , A61F2013/00906
摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.
摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 形成在载体的多孔片侧的与丙烯酸类聚合物相容的液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达非粘合层之间的层压体界面， - 多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。
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公开(公告)号：US5374429A
公开(公告)日：1994-12-20
申请号：US46962
申请日：1993-04-16
CPC分类号： A61K9/7061 , A61F13/023 , A61L15/58 , B32B27/12 , A61F2013/00578 , A61F2013/00604 , A61F2013/00744 , A61F2013/00906 , A61F2013/0091
摘要： A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 .mu.m and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m.sup.2, and a pressure-sensitive adhesive layer laminated on the surface of the nonwoven fabric.
摘要翻译： 一种医用胶粘片，其特征在于，具有由厚度为0.5〜6μm的聚酯薄膜和单位面积重量为5〜20g / m 2的聚酯无纺布构成的层压体的层叠体和叠层的粘合剂层 在无纺织物的表面上。
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公开(公告)号：US5204109A
公开(公告)日：1993-04-20
申请号：US855493
申请日：1992-03-23
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565
CPC分类号： A61K9/7061 , A61K31/34 , A61K31/565
摘要： A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) isosorbide dinitrate;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).
摘要翻译： 公开了一种经皮凝胶制剂，其包含其一个表面具有通过交联包含以下成分（a）至（c）的组合物，成分（b）与成分（c）的重量比）形成的交联凝胶层的基材 ）为1.0 / 0.25〜1.0 / 2.0：（a）硝酸异山梨酯; （b）丙烯酸酯聚合物; 和（c）与成分（b）相容的液体成分。
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公开(公告)号：US20060034901A1
公开(公告)日：2006-02-16
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 6 包括两种具有不同流动性的合成橡胶。
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40.发明授权公开(公告)号：US06231883B1
公开(公告)日：2001-05-15
申请号：US09117000
申请日：1998-07-17
申请人： Keigo Inosaka , Takateru Muraoka , Hitoshi Akemi , Saburo Otsuka , Yuichi Inoue
发明人： Keigo Inosaka , Takateru Muraoka , Hitoshi Akemi , Saburo Otsuka , Yuichi Inoue
IPC分类号： A61L1524
CPC分类号： A61L15/58
摘要： A medical adhesive sheet comprising a support and an adhesive layer formed on one side of said support, wherein the adhesive layer comprises an adhesive polymer having a weight average molecular weight of not less than 2,000,000, preferably not less than 2,500,000, and at least one plasticizer compatible with said polymer. The medical adhesive sheet of the present invention simultaneously satisfies the adhesive property to the skin and low irritation property, since it can retain the plasticizer in the adhesive layer, even without a crosslinking treatment. The effects of the present invention can be exerted irrespective of the kind of functional group that the plasticizer and drug have.
摘要翻译： 一种医用粘合片，其包含支撑体和形成在所述支撑体的一侧上的粘合剂层，其中所述粘合剂层包含重均分子量不小于2,000,000，优选不小于2,500,000的粘合剂聚合物，以及至少一种增塑剂 与所述聚合物相容。 本发明的医用粘合片同时满足与皮肤的粘合性和低刺激性，因为即使不进行交联处理也能够将增塑剂保留在粘合剂层中。 无论增塑剂和药物具有的官能团的种类如何，都可以发挥本发明的效果。
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