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公开(公告)号：US07754235B2
公开(公告)日：2010-07-13
申请号：US11410003
申请日：2006-04-25
CPC分类号： C09J133/14 , Y10T428/2891 , Y10T428/31935
摘要： The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.
摘要翻译： 本发明提供能够提供粘合剂层的粘合剂，粘合剂层显示出降低的粘性，减少的内聚破坏等。 含有通过使包含（甲基）丙烯酸烷基酯作为主要成分的单体和具有羟基和/或羧基的乙烯基单体共聚而得到的平均分子半径不小于70nm的共聚物 通过多角度激光散射法测量。
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公开(公告)号：US20060246281A1
公开(公告)日：2006-11-02
申请号：US11410003
申请日：2006-04-25
CPC分类号： C09J133/14 , Y10T428/2891 , Y10T428/31935
摘要： The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.
摘要翻译： 本发明提供能够提供粘合剂层的粘合剂，粘合剂层显示出降低的粘性，减少的内聚破坏等。 含有通过使包含（甲基）丙烯酸烷基酯作为主要成分的单体和具有羟基和/或羧基的乙烯基单体共聚而得到的平均分子半径不小于70nm的共聚物 通过多角度激光散射法测量。
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公开(公告)号：US20060292210A1
公开(公告)日：2006-12-28
申请号：US11447046
申请日：2006-06-06
申请人： Keigo Inosaka , Takateru Muraoka , Yoshihiro Iwao , Akio Takada , Toshinobu Tsuda , Junichi Sekiya
发明人： Keigo Inosaka , Takateru Muraoka , Yoshihiro Iwao , Akio Takada , Toshinobu Tsuda , Junichi Sekiya
IPC分类号： A61K9/70 , A61K31/137
CPC分类号： A61K31/135 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of selegiline or selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off, is provided. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing a metal chloride, an adhesive and at least one of (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and its hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
摘要翻译： 一种用于经皮给药司来吉兰或司来吉兰盐酸盐的稳定的经皮吸收型药物制剂，其即使在汗液组分由于汗液在磨损期间也不会降低粘合剂层的内聚力，并且不含内聚 提供了剥离时残留的失效和残留的粘合剂。 一种经皮吸收型药物制剂，其包含：载体; 以及含有金属氯化物，粘合剂和（ - ） - （R）-N，α-二甲基-N-二丙炔基苯乙胺及其盐酸盐中的至少一种的粘合剂层，其中对粘合剂层进行交联处理。
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公开(公告)号：US08409609B2
公开(公告)日：2013-04-02
申请号：US11446125
申请日：2006-06-05
申请人： Keigo Inosaka , Junichi Sekiya , Akio Takada , Toshinobu Tsuda
发明人： Keigo Inosaka , Junichi Sekiya , Akio Takada , Toshinobu Tsuda
IPC分类号： A61F13/00
CPC分类号： A61K31/275 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of drugs except for selegiline and selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing an adhesive, a metal chloride and a percutaneously-absorptive drug except for selegiline and selegiline hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
摘要翻译： 一种用于经皮给药的稳定的经皮吸收型药物，除了司来吉兰和司来吉兰盐酸盐以外，其中即使在由于穿着期间出汗引起的汗液成分的情况下也不会使粘合剂层的内聚力降低， 剥离时没有内聚破坏和残留的粘合剂。 一种经皮吸收型药物制剂，其包含：载体; 以及含有粘合剂，金属氯化物和除了司来吉兰和司来吉兰盐酸盐以外的经皮吸收药物的粘合剂层，其中对粘合剂层进行交联处理。
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公开(公告)号：US20060275354A1
公开(公告)日：2006-12-07
申请号：US11446125
申请日：2006-06-05
申请人： Keigo Inosaka , Junichi Sekiya , Akio Takada , Toshinobu Tsuda
发明人： Keigo Inosaka , Junichi Sekiya , Akio Takada , Toshinobu Tsuda
IPC分类号： A61K9/70
CPC分类号： A61K31/275 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of drugs except for selegiline and selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing an adhesive, a metal chloride and a percutaneously-absorptive drug except for selegiline and selegiline hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
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公开(公告)号：US20110056863A1
公开(公告)日：2011-03-10
申请号：US12990818
申请日：2009-05-26
IPC分类号： B65D85/00 , A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K9/7061 , A61K31/4465 , B65D81/24
摘要： [Object] An adhesive preparation containing donepezil is provided in which adhesive layer discoloration over time is inhibited.[Solution] The adhesive preparation containing donepezil has an adhesive layer containing donepezil and an acrylic adhesive on at least one side of a support, and a water content of the adhesive layer is 1000 ppm or more. The water content of the adhesive layer is preferably 8000 ppm or less and more preferably 7000 ppm or less.
摘要翻译： 提供了含有多奈哌齐的粘合剂，其中粘合剂层随着时间的变色被抑制。 [解决方案]含有多奈哌齐的粘合剂在载体的至少一侧上具有含有多奈哌齐和丙烯酸类粘合剂的粘合剂层，粘合剂层的含水量为1000ppm以上。 粘合剂层的含水量优选为8000ppm以下，更优选为7000ppm以下。
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公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译： 本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于 使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。
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公开(公告)号：US08033395B2
公开(公告)日：2011-10-11
申请号：US12314564
申请日：2008-12-12
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在 补丁1。
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9.发明申请METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARTION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED 审中-公开用于抑制含有二苯醚的粘合制剂的着色方法和减少形成的与二苯醚相关的物质的量的方法公开(公告)号：US20100062045A1
公开(公告)日：2010-03-11
申请号：US12516998
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61K9/70 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.
摘要翻译： 通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯 并且在压敏粘合剂层中含有偏亚硫酸氢盐。 该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。
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10.发明申请METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL 审中-公开用于抑制含有二苯醚的胶粘剂制备时间的消除方法公开(公告)号：US20100048628A1
公开(公告)日：2010-02-25
申请号：US12517004
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.
摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂 和多奈哌齐。
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