公开(公告)号：US20090298878A1

公开(公告)日：2009-12-03

申请号：US12373328

申请日：2007-07-12

申请人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

发明人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

IPC分类号： A61K31/445 ,  C07D211/98 ,  G01N23/00 ,  C07D401/12

CPC分类号： C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式（I）的肟化合物及其药学上可接受的盐，前药或溶剂化物，其中X是氢，任选取代的芳基，任选取代的杂芳基等; Y是CO，SO2，CR3R4等; Z是任选取代的低级烷基，任选取代的芳基等; W是任选取代的低级亚烷基或任选取代的低级亚烯基，R 3和R 4各自独立地是氢，低级烷基等; p是0,1或2，q是0,1或2.本发明还涉及使用式I化合物来治疗，预防或改善对阻断钙通道有响应的病症，特别是N型 钙通道。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US06511878B1

公开(公告)日：2003-01-28

申请号：US10212259

申请日：2002-08-06

申请人： Akira Matsumura

发明人： Akira Matsumura

IPC分类号： H01L218242

CPC分类号： H01L27/10894 ,  H01L27/10897 ,  H01L28/84 ,  H01L28/91

摘要： According to a manufacturing method for this semiconductor device, an etching process is carried out through wet etching so that a storage node interlayer insulating film has an etching rate with respect to an etchant for wet etching greater than that of a second interlayer insulating film and an opening first contact hole provided on storage node interlayer insulating film becomes greater than that of a first contact hole provided on second interlayer insulating film. By adopting this method, it becomes possible to obtain a semiconductor device capable of increasing a capacitance of a capacitor while an easy process can be adopted.

摘要翻译： 根据该半导体装置的制造方法，通过湿蚀刻进行蚀刻处理，使得存储节点层间绝缘膜相对于比第二层间绝缘膜大的蚀刻剂的蚀刻速率， 设置在存储节点层间绝缘膜上的打开的第一接触孔变得大于设置在第二层间绝缘膜上的第一接触孔的开口第一接触孔。 通过采用该方法，可以获得能够增加电容器的电容的半导体器件，同时可以采用简单的过程。

公开(公告)号：US5315409A

公开(公告)日：1994-05-24

申请号：US838496

申请日：1992-02-19

申请人： Akira Matsumura ,  Ryuji Kitakado

发明人： Akira Matsumura ,  Ryuji Kitakado

IPC分类号： H04N1/403 ,  G06K9/38 ,  G06T1/00 ,  G06T5/00 ,  G06T5/40 ,  H01N1/40

CPC分类号： G06K9/38 ,  G06T5/009 ,  G06T2207/20148 ,  G06T2207/30141

摘要： A frequency distribution or histogram M (L.sub.j-1, L.sub.j) of differences between gradation levels (L.sub.j-1, L.sub.j) of adjacent pixels (P.sub.j-1, P.sub.j) in an image is obtained, and the number of level-changes for each tentative threshold level L.sub.j is determined as a function of the histogram of the level differencies. By using the number of level-changes, an optimum binarization threshold level is set by means of an adaptive thresholding method. Since the number of level-changes is calculated from the histogram of the level-differencies without practical binarization for each threshold level, the amount of calculations is not dependent on the number of pixels but on the number of gradation levels. The calculations for setting the threshold level for the binarization of the image are achieved at high speeds by a small-scale hardware.

摘要翻译： 获得图像中的相邻像素（Pj-1，Pj）的灰度等级（Lj-1，Lj）之间的差的频率分布或直方图M（Lj-1，Lj），并且获得每个 确定临时阈值水平Lj作为水平差异的直方图的函数。 通过使用电平变化的数量，通过自适应阈值法来设置最优二值化阈值电平。 由于根据电平差异的直方图计算出电平变化的数量，而对于每个阈值电平没有实际的二值化，所以计算量不依赖于像素的数量，而是依赖于灰度级数。 用于设置图像二值化阈值水平的计算是通过小规模硬件在高速度下实现的。

公开(公告)号：US5227044A

公开(公告)日：1993-07-13

申请号：US925128

申请日：1992-08-06

申请人： Akira Matsumura ,  Masashi Ohata

发明人： Akira Matsumura ,  Masashi Ohata

IPC分类号： G02B5/20 ,  G02F1/1335 ,  G03F7/00 ,  G03F7/20

CPC分类号： G02F1/133512 ,  G03F7/0007 ,  G03F7/2022

摘要： The present invention provides a process for producing a multicolor display without a photolithographic process which requires registration. The process comprises forming a transparent electroconductive layer on a transparent substrate, forming a desired colored layer patterned thereon, and subjecting the transparent electroconductive layer exposed between the gap of the patterned colored layers to a metal electroplating (or electrolytic reduction) to form a light-shielding layer.

公开(公告)号：US4359712A

公开(公告)日：1982-11-16

申请号：US133259

申请日：1980-03-24

申请人： Akira Matsumura

发明人： Akira Matsumura

IPC分类号： H04B7/26 ,  G08G1/09 ,  G08G1/0962 ,  G08G1/00 ,  G08C21/00 ,  G08G1/12

CPC分类号： G08G1/094 ,  H04B17/318

摘要： A communications system for automotive vehicles includes a fixed unit for transmitting an area signal at all times and information signals when, based upon a request signal, it is decided to do so, and a mobile unit mounted on an automotive vehicle for receiving the area signal when the automotive vehicle passes through a communications area and for then transmitting a request signal to receive the information signals from the fixed unit, and is so constructed that the mobile unit first transmits a request signal to the fixed unit, when the automotive vehicle first comes into the communications area, and next the fixed unit transmits the information to the mobile unit after the automotive vehicle further comes nearer to the fixed unit, whereby drops in electric field strength received by the mobile unit are prevented from interrupting the communications of the information, and a stable communications between a fixed communications unit and a mobile communications unit are maintained.

摘要翻译： 一种用于机动车辆的通信系统包括：一个固定单元，用于一直发送一个区域信号和信息信号，当根据一个请求信号决定这样做时，一个安装在机动车上的移动单元用于接收该区域信号 当机动车辆通过通信区域然后发送请求信号以从固定单元接收信息信号时，并且被构造成使得移动单元首先向固定单元发送请求信号，当机动车辆首次到达时 进入通信区域，接下来，在机动车辆进一步靠近固定单元之后，固定单元将信息发送到移动单元，由此防止移动单元接收到的电场强度的下降中断该信息的通信， 并且维持固定通信单元和移动通信单元之间的稳定通信。

公开(公告)号：US4354191A

公开(公告)日：1982-10-12

申请号：US168158

申请日：1980-07-14

申请人： Akira Matsumura ,  Yoichi Kaneko ,  Kenji Sekine ,  Akira Endo

发明人： Akira Matsumura ,  Yoichi Kaneko ,  Kenji Sekine ,  Akira Endo

IPC分类号： G01S7/36 ,  G01S13/02 ,  G01S13/60 ,  G01S13/58

CPC分类号： G01S7/023 ,  G01S13/60 ,  G01S7/36

摘要： A Doppler radar wherein, in order to measure the ground speed of an automobile, microwaves are radiated to the ground and the Doppler shift of reflected waves from the ground is detected, characterized in that to the end of avoiding a malfunction ascribable to an external microwave interference, when the differentiated output of the Doppler radar is greater than a threshold value, the frequency of the microwaves of the Doppler radar is controlled so as to prevent the microwave interference from taking place.

摘要翻译： 一种多普勒雷达，其中为了测量汽车的地面速度，微波被辐射到地面，并且检测到来自地面的反射波的多普勒偏移，其特征在于，为了避免归因于外部微波的故障 干扰，当多普勒雷达的微分输出大于阈值时，控制多普勒雷达的微波频率，以防止微波干扰发生。

公开(公告)号：US4332993A

公开(公告)日：1982-06-01

申请号：US259366

申请日：1981-04-30

申请人： Jun Shibahara ,  Akira Matsumura

发明人： Jun Shibahara ,  Akira Matsumura

IPC分类号： H05B6/80 ,  A47J36/38

CPC分类号： H05B6/642

摘要： A microwave oven of the type which is built in a recess formed in a wall of, for example, a home kitchen includes a box-like air guide member to be mounted on the microwave oven. The air guide member generally comprises side panels, front and rear panels, and top panel, and the front panel is provided with an opening for exhausting air used to cool the microwave oven to the atmosphere. An electric fan may be accommodated in the air guide member for enhancing the cooling effect.

摘要翻译： 构成在例如家用厨房的壁上的凹部中的微波炉包括要安装在微波炉上的盒状导风构件。 空气引导构件通常包括侧板，前后面板和顶板，并且前面板设置有用于排出用于将微波炉冷却至大气的空气的开口。 电风扇可以容纳在导风构件中，以增强冷却效果。

公开(公告)号：US08895551B2

公开(公告)日：2014-11-25

申请号：US13260185

申请日：2010-04-02

申请人： Hidenori Mikamiyama ,  Akira Matsumura ,  Moriyasu Masui ,  Kosuke Anan ,  Kayoko Hata

发明人： Hidenori Mikamiyama ,  Akira Matsumura ,  Moriyasu Masui ,  Kosuke Anan ,  Kayoko Hata

IPC分类号： A61K31/5377 ,  C07D265/30 ,  A61K31/445 ,  C07D211/68 ,  C07D401/00 ,  C07D405/00 ,  C07D211/70 ,  C07D211/96

CPC分类号： C07D211/70 ,  C07D211/96

摘要： The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及下述式I的丙烯酰胺化合物。 本发明还涉及使用式I化合物来治疗或预防对阻塞钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US20110172415A1

公开(公告)日：2011-07-14

申请号：US13050465

申请日：2011-03-17

申请人： Moriyasu Masui ,  Makoto Adachi ,  Hidenori Mikamiyama ,  Akira Matsumura ,  Naoki Tsuno

发明人： Moriyasu Masui ,  Makoto Adachi ,  Hidenori Mikamiyama ,  Akira Matsumura ,  Naoki Tsuno

IPC分类号： C07D498/04 ,  C07D401/12 ,  C07D405/12 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D403/12 ,  C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D295/185 ,  C07D413/12

CPC分类号： C07D209/08 ,  C07D209/34 ,  C07D215/38 ,  C07D235/08 ,  C07D235/26 ,  C07D249/18 ,  C07D263/58 ,  C07D277/68 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

摘要： It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein Z is N or CR1, A1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R1, R2, Ra, Rb, Rc and Rd are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is —(CR3R4)m-, —CO(CR3R4)n-, —CONR5(CR3R4)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R3 and R4 are each independently hydrogen, halogen, hydroxy etc., and R5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or a solvate thereof.

摘要翻译： 发现由式（I）表示的含氮杂环衍生物特异性结合NR1 / NR2B的受体，并用作NR2B受体拮抗剂。 由下式表示的化合物：其中Z为N或CR1，A1为任选取代的含氮芳族单环基团，任选取代的含氮芳族稠合环基等，A2为芳族烃环基或 芳族杂环基，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或2，X为 - （CR 3 R 4）m - ，-CO（CR 3 R 4）n - ， - CONR 5（CR 3 R 4）n - 等，m为1〜4的整数，n为0〜4的整数，R 3和R 4各自独立地为氢，卤素，羟基等 R5为氢或低级烷基，或其药学上可接受的盐或溶剂合物。

公开(公告)号：US20090306136A1

公开(公告)日：2009-12-10

申请号：US12296788

申请日：2007-04-13

申请人： Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

发明人： Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

IPC分类号： A61K31/4468 ,  G01N33/53 ,  A61K31/4545 ,  A61K31/454 ,  C07D401/06 ,  C07D211/56 ,  A61P25/00

CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4545

摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1-R3，Z，p和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。