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55 条记录 (耗时 0.038 秒)

    Procyanidin compositions and methods for making the same
    31.
    发明授权
    Procyanidin compositions and methods for making the same 失效
    含有原花青素的药物组合物

    公开(公告)号：US06479539B1

    公开(公告)日：2002-11-12

    申请号：US08837803

    申请日：1997-04-22

    申请人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    发明人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    IPC分类号： A01N4316

    CPC分类号： A61K31/78 ,  A23L33/105 ,  A61K31/353 ,  A61K36/185 ,  C07D311/62

    摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins-and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.

    摘要翻译： 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物以及用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。

    Methods of using procyanidin antioxidants
    32.
    发明授权
    Methods of using procyanidin antioxidants 有权
    含有可可多酚的黄嘌呤生物碱类可可提取物

    公开(公告)号：US06225338B1

    公开(公告)日：2001-05-01

    申请号：US09172873

    申请日：1998-10-15

    申请人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    发明人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    IPC分类号： A01N4316

    CPC分类号： A61K31/78 ,  A23L33/105 ,  A61K31/353 ,  A61K36/185 ,  C07D311/62

    摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins-and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.

    摘要翻译： 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物以及用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。

    Cocoa extracts as antioxidants
    36.
    发明授权
    Cocoa extracts as antioxidants 有权
    可可提取物作为抗氧化剂

    公开(公告)号：US07820713B2

    公开(公告)日：2010-10-26

    申请号：US11745698

    申请日：2007-05-08

    申请人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    发明人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    IPC分类号： A01N43/16 ,  A61K31/35 ,  C07D313/00 ,  A23L1/28

    CPC分类号： A61K31/78 ,  A23L33/105 ,  A61K31/353 ,  A61K36/185 ,  C07D311/62

    摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topoisomerase-inhibiting compositions and methods.

    摘要翻译： 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。

    Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
    40.
    发明授权
    Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide 有权
    食品中含有多酚和L-精氨酸刺激一氧化氮

    公开(公告)号：US06805883B2

    公开(公告)日：2004-10-19

    申请号：US10176126

    申请日：2002-06-19

    申请人： Kati A. Chevaux ,  Harold H. Schmitz ,  Leo J. Romanczyk, Jr.

    发明人： Kati A. Chevaux ,  Harold H. Schmitz ,  Leo J. Romanczyk, Jr.

    IPC分类号： A61K3578

    CPC分类号： A23G1/44 ,  A23G1/48 ,  A23G1/56 ,  A23G2200/10 ,  A23G2200/14 ,  A23L33/105 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/197 ,  A61K36/185 ,  A61K2300/00 ,  A23V2250/2132 ,  A23V2250/0606

    摘要： Foods and pharmaceuticals which contain cocoa and/or nut procyanidin(s) in combination with L-arginine are effective to induce a physiological increase in nitric oxide production in a mammal having ingested the product. A preferred food product is a confection, particularly a dark or milk chocolate containing nuts. The procyanidins may be natural or synthetic and may be provided by food ingredients such as chocolate liquor and/or cocoa solids prepared from underfermented beans and nut skins. The L-arginine may be natural or synthetic and may be provided by food ingredients such as nut meats, nut pastes, and/or nut flours, seeds, seed pastes, and/or seed flours, or gelatin. The beneficial health effects may include, for example, reduced blood pressure, resistance to cardiovascular disease, and anticancer activity.

    摘要翻译： 含有可可和/或坚果原花青素与L-精氨酸组合的食品和药物有效地诱导摄入该产品的哺乳动物中一氧化氮产生的生理增加。 优选的食品是甜食，特别是含有坚果的黑色或牛奶巧克力。 原花青素可以是天然的或合成的，并且可以由食物成分提供，例如由未发酵的豆和坚果皮制备的巧克力浆和/或可可固体。 L-精氨酸可以是天然的或合成的，并且可以由食品成分例如坚果肉，坚果糊和/或坚果面粉，种子，种子糊和/或种子面粉或明胶提供。 有益的健康影响可以包括例如降低血压，抗心血管疾病和抗癌活性。