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公开(公告)号：US07226762B2
公开(公告)日：2007-06-05
申请号：US10495291
申请日：2002-11-11
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/0006 , C07K14/415
摘要： The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶突变体的分离的核酸分子，以及包含这种核酸分子的载体和宿主细胞。 这些核酸分子参与精细化学品的生物合成，例如氨基酸如赖氨酸。 本发明还涉及通过在产生精细化学品的条件下培养含有这些核酸分子的重组微生物来生产和调节精细化学品如赖氨酸的生产方法。
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32.发明授权公开(公告)号：US07138513B2
公开(公告)日：2006-11-21
申请号：US10494541
申请日：2002-10-31
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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公开(公告)号：US08728795B2
公开(公告)日：2014-05-20
申请号：US12038642
申请日：2008-02-27
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US07785779B2
公开(公告)日：2010-08-31
申请号：US10582918
申请日：2004-12-15
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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35.发明授权Method for the production of sulpher-containing fine chemicals by fermentation 有权通过发酵生产含有精液的精细化学品的方法公开(公告)号：US07635580B2
公开(公告)日：2009-12-22
申请号：US10514489
申请日：2003-05-23
CPC分类号： C12N9/1085 , C12P13/12 , C12R1/15
摘要： The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.
摘要翻译： 本发明涉及通过使用表达编码S-腺苷甲硫氨酸合成酶（metK）基因的核苷酸序列的细菌的发酵来生产含硫精细化学物质，特别是L-甲硫氨酸的方法。
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公开(公告)号：US20090298137A1
公开(公告)日：2009-12-03
申请号：US12091948
申请日：2006-10-23
申请人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译： 本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。 特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。
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公开(公告)号：US07141664B2
公开(公告)日：2006-11-28
申请号：US10494836
申请日：2002-10-31
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C07K14/34 , C12N9/00 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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38.发明授权公开(公告)号：US07381549B2
公开(公告)日：2008-06-03
申请号：US10525710
申请日：2003-08-26
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metH）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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公开(公告)号：US07355032B2
公开(公告)日：2008-04-08
申请号：US11603384
申请日：2006-11-21
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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公开(公告)号：US07355029B2
公开(公告)日：2008-04-08
申请号：US11594611
申请日：2006-11-08
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C07K14/34 , C12N9/00 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of the genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途，以及借助遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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