公开(公告)号：US20120116382A1

公开(公告)日：2012-05-10

申请号：US13281360

申请日：2011-10-25

申请人： Vincent Ku ,  Robert Beetel ,  Andrew Wu ,  Denise Zarins ,  Maria G. Aboytes

发明人： Vincent Ku ,  Robert Beetel ,  Andrew Wu ,  Denise Zarins ,  Maria G. Aboytes

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

公开(公告)号：US20110200171A1

公开(公告)日：2011-08-18

申请号：US13009748

申请日：2011-01-19

申请人： Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

发明人： Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61B6/506 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61N5/1067 ,  A61N7/02 ,  A61N2005/1061

摘要： The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

摘要翻译： 本公开描述了通过立体定向放射治疗高血压，心力衰竭，慢性肾脏疾病，糖尿病，胰岛素抵抗，代谢紊乱或其它疾病的肾神经调节的方法和装置。 肾神经调节可以通过定位肾神经，然后利用立体定向放射治疗来将肾神经暴露于足以减少神经活动的辐射剂量来实现。 可以提供用于定位目标肾神经的神经定位元件，并且可以提供立体定向放射治疗系统，用于将位于所述肾神经的辐射剂量暴露于足以减少或最小化相邻组织中的辐射暴露的神经活动的辐射剂量。 肾神经可能位于神经节水平和/或神经节后位置以及神经节前位置。

公开(公告)号：US07880455B2

公开(公告)日：2011-02-01

申请号：US12715959

申请日：2010-03-02

申请人： Andrew Wu

发明人： Andrew Wu

IPC分类号： G05F1/00

CPC分类号： H02M3/1588 ,  H02M1/32 ,  H02M2001/0009 ,  Y02B70/1466

摘要： A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

摘要翻译： 公开了一种具有高侧通装置和低侧通装置的调节器，其与高侧通路装置串联耦合。 该装置还包括耦合到高侧通路装置和低侧通路装置的控制模块。 控制模块耦合到高侧通设备和低侧通设备，以控制高侧通设备和低侧通设备。 控制模块可操作以在某些条件下锁定高侧通过装置。

公开(公告)号：US20100249773A1

公开(公告)日：2010-09-30

申请号：US12759641

申请日：2010-04-13

申请人： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

发明人： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

IPC分类号： A61F7/12 ,  A61B18/08

CPC分类号： A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

摘要： The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

摘要翻译： 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括用于限制血管内治疗装置相对于手柄组件的独立旋转的旋转限制元件。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

公开(公告)号：US20100185968A1

公开(公告)日：2010-07-22

申请号：US12636520

申请日：2009-12-11

申请人： Yun-Ping Hsu ,  Majed Itani ,  Ajay Gupta ,  Roger Smith ,  Rob Aagaard ,  Andrew Wu ,  Collin Lee ,  Lila Alexei Tretikov

发明人： Yun-Ping Hsu ,  Majed Itani ,  Ajay Gupta ,  Roger Smith ,  Rob Aagaard ,  Andrew Wu ,  Collin Lee ,  Lila Alexei Tretikov

IPC分类号： G06F3/048 ,  G06F17/30

CPC分类号： G06Q30/02

摘要： A business software application system and method are provided that include a feed system for distributing changes about the application/module to a group of users and a cloud connector system that links external data sources to the business software application system and method.

摘要翻译： 提供了一种商业软件应用系统和方法，其包括用于将关于应用/模块的改变分发给一组用户的馈送系统和将外部数据源连接到商业软件应用系统和方法的云连接器系统。

公开(公告)号：US20090070744A1

公开(公告)日：2009-03-12

申请号：US12200301

申请日：2008-08-28

申请人： Jacob Andrew Taylor ,  Majed Itani ,  Ajay Gupta ,  Andrew Wu ,  Joseph Parsons ,  Roger Smith ,  Chris Nojima

发明人： Jacob Andrew Taylor ,  Majed Itani ,  Ajay Gupta ,  Andrew Wu ,  Joseph Parsons ,  Roger Smith ,  Chris Nojima

IPC分类号： G06F9/44

CPC分类号： G06Q10/10 ,  G06F11/3409 ,  G06F11/3466 ,  G06F2201/80

摘要： A business application system, such as a CRM system, is provided wherein the system include deeper chart drill-downs, access control lists, shared folders, a tracker module and/or a modular builder.

摘要翻译： 提供了诸如CRM系统的业务应用系统，其中系统包括更深的图表深入，访问控制列表，共享文件夹，跟踪器模块和/或模块化构建器。

公开(公告)号：US20070279024A1

公开(公告)日：2007-12-06

申请号：US10587785

申请日：2004-02-05

申请人： Christopher Falvey ,  Andrew Wu

发明人： Christopher Falvey ,  Andrew Wu

IPC分类号： G05F1/10

CPC分类号： H02M3/158 ,  H02M2001/0009 ,  H02M2001/0045

摘要： A switch-mode DC/DC converter (101) and linear low drop out (LIDO) DC/DC regulator (105) are connected in parallel to drive a single load Both regulators share a common voltage reference, feedback network (103), input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator (107) is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator (107) disabled, also maximizing the efficiency. Each regulator senses load current (131) to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators (103) to minimize the voltage transients.

摘要翻译： 开关模式DC / DC转换器（101）和线性低压降（LIDO）DC / DC稳压器（105）并联连接以驱动单个负载。两个稳压器共享公共参考电压，反馈网络（103），输入 供应和输出，使得在每个操作模式期间调节电压相同。 在重负载期间，开关模式稳压器（107）处于工作状态，线性稳压器被禁用，以实现最高的效率。 相反，轻负载时，线性稳压器在开关模式稳压器（107）禁用的情况下运行，同时也使效率最大化。 每个调节器感测负载电流（131），以在固定负载电流水平下自适应在适当的电压调节器之间转换。 本发明还包括电压调节器（103）的断开前转换方案以最小化电压瞬变。

公开(公告)号：US20060262439A1

公开(公告)日：2006-11-23

申请号：US11133493

申请日：2005-05-19

申请人： Andrew Wu

发明人： Andrew Wu

IPC分类号： G11B5/00

CPC分类号： G11B5/3166 ,  G11B5/3169 ,  G11B5/3173 ,  G11B5/3903 ,  G11B5/3929 ,  G11B5/40

摘要： In one aspect described herein, a read head having one or more magnetoresistive (MR) sensors (or devices) is provided. In one example, the read head includes an MR sensor and an insulator layer disposed at the same level as the MR sensor. The read head further includes a bearing surface, wherein the insulator layer forms a portion of the bearing surface and is disposed between a surface of the MR sensor and the bearing surface to provide protection for the MR sensor from exposure to the bearing surface. The MR sensor may include a stack of thin-film layers to form an AMR, GMR, or TGMR sensor element. The stack may further include a slanted surface portion, wherein the insulator layer is disposed on the slanted surface portion, thereby recessing the MR sensor from the bearing surface.

摘要翻译： 在本文描述的一个方面，提供了具有一个或多个磁阻（MR）传感器（或设备）的读取头。 在一个示例中，读取头包括布置在与MR传感器相同水平的MR传感器和绝缘体层。 所述读取头还包括支承表面，其中所述绝缘体层形成所述支承表面的一部分并且设置在所述MR传感器的表面和所述支承表面之间，以提供所述MR传感器不受暴露于所述支承表面的保护。 MR传感器可以包括一叠薄膜层以形成AMR，GMR或TGMR传感器元件。 叠层还可包括倾斜表面部分，其中绝缘体层设置在倾斜表面部分上，从而将MR传感器从轴承表面凹入。

公开(公告)号：US20060050449A1

公开(公告)日：2006-03-09

申请号：US11216276

申请日：2005-08-30

申请人： Andrew Wu

发明人： Andrew Wu

IPC分类号： H02H7/00

CPC分类号： H02M3/1588 ,  H02M1/32 ,  H02M2001/0009 ,  Y02B70/1466

摘要： In an embodiment, an apparatus is provided. The apparatus includes a high side pass device. The apparatus also includes a low side pass device coupled in series to the high side pass device. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. Additionally, the apparatus includes a first resistor coupled in series with the high side pass device and the low side pass device. Furthermore, the apparatus includes a first comparator coupled in parallel with the first resistor. The first comparator has a threshold voltage input differential corresponding to a first current limit, and an output of the first comparator is coupled to the control module. Moreover, the apparatus includes a second comparator coupled to sense current of the high side pass device as a voltage. The second comparator has a threshold voltage input differential corresponding to a second current limit. An output of the second comparator is coupled to the control module. The second current limit is higher than the first current limit. Also, the control module is operable to lock out the high side pass device responsive to the output of the first comparator until a reset signal is received and is operable to lock out the high side pass device responsive to the output of the second comparator until a low current signal is received.

摘要翻译： 在一个实施例中，提供了一种装置。 该装置包括高边通装置。 该装置还包括与高侧通路装置串联耦合的低通边装置。 该装置还包括耦合到高侧通路装置和低侧通路装置的控制模块。 控制模块耦合到高侧通设备和低侧通设备，以控制高侧通设备和低侧通设备。 另外，该装置包括与高边通装置和低边通装置串联耦合的第一电阻器。 此外，该装置包括与第一电阻器并联耦合的第一比较器。 第一比较器具有对应于第一电流限制的阈值电压输入差分，并且第一比较器的输出耦合到控制模块。 而且，该装置包括一个第二比较器，该第二比较器被耦合以感测作为电压的高侧通过装置的电流。 第二比较器具有对应于第二电流限制的阈值电压输入差分。 第二比较器的输出耦合到控制模块。 第二个电流限制高于第一个电流限制。 此外，控制模块可操作以响应于第一比较器的输出来锁定高侧通过装置，直到接收到复位信号，并且可操作以响应于第二比较器的输出来锁定高侧通过装置，直到 接收到低电流信号。

公开(公告)号：US10034708B2

公开(公告)日：2018-07-31

申请号：US14737254

申请日：2015-06-11

申请人： Denise Zarins ,  Andrew Wu ,  Hanson Gifford, III ,  Mark Deem ,  Mark Gelfand ,  Howard R. Levin

发明人： Denise Zarins ,  Andrew Wu ,  Hanson Gifford, III ,  Mark Deem ,  Mark Gelfand ,  Howard R. Levin

IPC分类号： A61B18/14 ,  A61F7/12 ,  A61M5/142 ,  A61N1/28 ,  A61N1/32 ,  A61N1/40 ,  A61N5/04 ,  A61N7/02 ,  A61M5/172 ,  A61N1/36 ,  A61N1/362 ,  A61N7/00 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61F7/123 ,  A61F2007/126 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/1082 ,  A61N1/28 ,  A61N1/32 ,  A61N1/326 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/403 ,  A61N5/045 ,  A61N7/02 ,  A61N2007/003

摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.