公开(公告)号：US08846742B2

公开(公告)日：2014-09-30

申请号：US11674965

申请日：2007-02-14

申请人： Richard Ambron ,  Ying-Ju Sung ,  Jeremy Greenwood ,  Leah Frye ,  Shi-Xian Deng ,  Yuli Xie ,  Donald W. Landry

发明人： Richard Ambron ,  Ying-Ju Sung ,  Jeremy Greenwood ,  Leah Frye ,  Shi-Xian Deng ,  Yuli Xie ,  Donald W. Landry

IPC分类号： A61K31/415 ,  A61K31/335

CPC分类号： A61K31/40 ,  A61K31/235 ,  A61K31/335

摘要： The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the active site of PKG and/or are analogs of balanol.

摘要翻译： 本发明涉及可用于抑制蛋白激酶G（“PKG”）活化的化合物。 至少部分基于PKG的三级结构的发现以及与PKG的活性位点结合的分子的鉴定和/或是平衡醇的类似物。

公开(公告)号：US08637009B2

公开(公告)日：2014-01-28

申请号：US12667895

申请日：2008-07-10

申请人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovich ,  John J. Tesmer ,  Remy L. Brim

发明人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovich ,  John J. Tesmer ,  Remy L. Brim

IPC分类号： A61K38/46 ,  C12N9/96

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K31/505 ,  A61K45/06 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  C12N9/18 ,  C12Q1/44 ,  C12Y301/01084 ,  G01N2333/918 ,  A61K2300/00

摘要： Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

摘要翻译： 提供了包含可卡因酯酶（CocE）和使CocE稳定化合物的组合物。 还提供了热稳定可卡因酯酶的方法。 另外提供了治疗经历可卡因诱导病症的哺乳动物的方法。 还提供了确定化合物是否是蛋白质的热稳定剂的方法。 另外提供了上述用于治疗可卡因诱导病症的组合物的用途。 另外提供了编码具有取代L169K和G173Q的CocE多肽和由该核酸编码的CocE多肽的分离的核酸及其药物组合物。 还提供了该组合物用于制备用于治疗可卡因诱导的病症和用于治疗可卡因诱导病症的药物的用途。

公开(公告)号：US20120269828A1

公开(公告)日：2012-10-25

申请号：US13452019

申请日：2012-04-20

申请人： Shi-Xian Deng ,  Donald W. Landry ,  Gavreel Kalantarov ,  Trakht IIya

发明人： Shi-Xian Deng ,  Donald W. Landry ,  Gavreel Kalantarov ,  Trakht IIya

IPC分类号： A61K39/385 ,  A61P37/04 ,  A61K39/44 ,  A61P25/30 ,  C07D451/12 ,  C07K17/02

CPC分类号： A61K39/0013 ,  A61K31/44 ,  A61K39/385 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/55566 ,  A61K2039/6056 ,  A61K2039/6081

摘要： The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject.

摘要翻译： 本发明涉及基于药物和非免疫原性载体蛋白质之间的缀合物的抗药物疫苗。 在优选的实施方案中，它提供了抗可卡因疫苗及其用于减少受试者中可卡因的作用和/或使用的用途。

公开(公告)号：US20120129939A1

公开(公告)日：2012-05-24

申请号：US13203649

申请日：2010-03-01

申请人： Scott A. Small ,  Nicole Lewandowski ,  Donald W. Landry ,  Shi-Xiang Deng

发明人： Scott A. Small ,  Nicole Lewandowski ,  Donald W. Landry ,  Shi-Xiang Deng

IPC分类号： A61K31/197 ,  A61P25/16 ,  C07D243/04 ,  C07D241/08 ,  A61K31/132 ,  C07C229/26

CPC分类号： A61K31/13 ,  A61K31/00

摘要： Disclosed herein are methods for treating a disease involving α-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α-synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Also disclosed are methods for reducing the amount of α-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α-synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.

摘要翻译： 本文公开了使用以下方法治疗涉及α-解聚聚集的疾病的方法：（1）减少多胺有效降低α-解磷聚集的量的化合物; （2）抑制多胺合成的化合物，其量有效降低α-解磷聚集; 或（3）以有效减少α-解聚聚集的量抑制α-突触聚集的化合物。 还公开了使用（1）以有效减少α-鸟氨酸聚集的量减少多胺的量的化合物来减少脑细胞中的α-突触聚集的量的方法; （2）抑制多胺合成的化合物，其量有效降低α-解磷聚集; 或（3）以有效减少α-解聚聚集的量抑制α-突触聚集的化合物。 本文公开的也是可以用于上述方法的化合物。

公开(公告)号：US07183255B2

公开(公告)日：2007-02-27

申请号：US10789548

申请日：2004-02-26

申请人： Donald W. Landry ,  Juan A. Oliver

发明人： Donald W. Landry ,  Juan A. Oliver

IPC分类号： A61K38/17

CPC分类号： A61K38/11

摘要： The present invention provides a method for regulating blood pressure in a hemodialysis subject using a vasopressin receptor agonist, so as to facilitate removal of excessive extracellular fluid in the subject.

摘要翻译： 本发明提供一种使用加压素受体激动剂调节血液透析患者的血压的方法，以便于去除受试者中过量的细胞外液。

公开(公告)号：US06913917B2

公开(公告)日：2005-07-05

申请号：US09940727

申请日：2001-08-28

申请人： Donald W. Landry

发明人： Donald W. Landry

IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/00 ,  A61K38/43

CPC分类号： C12N9/0002 ,  A61K38/00

摘要： Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration and a method for decreasing the concentration of cocaine of a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.

摘要翻译： 公开了能够降解可卡因的催化抗体和多肽。 所述催化抗体和多肽的特征在于其互补决定区和框架区的氨基酸序列。 本发明还公开了降低浓度的药物组合物和方法以及降低受试者可卡因浓度的方法。 最后，本发明公开了治疗可卡因过量和成瘾的药物组合物和方法。

公开(公告)号：US06620120B2

公开(公告)日：2003-09-16

申请号：US09083781

申请日：1998-05-22

申请人： Donald W. Landry ,  Howard R. Levin ,  Evan Stuart Garfein

发明人： Donald W. Landry ,  Howard R. Levin ,  Evan Stuart Garfein

IPC分类号： A61M3500

CPC分类号： A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3458

摘要： Disclosed herein is an apparatus that efficiently clears solutes from blood of patients with renal disease solely by convection and with a single filter that includes a hemofilter, a blood pump for drawing blood from a patient and propelling the blood into a mixing chamber, a mixing and detention chamber where the blood and a non-isosmotic diluent are mixed and are allowed to approach or reach equilibrium (with regard to solute concentration), a mixing element for creating turbulence in the mixing/detention chamber, and suitable tubing for carrying the pumped blood to and from the patent. Methods for utilizing the apparatus are also disclosed.

摘要翻译： 本文公开了一种能够仅通过对流有效地从具有肾脏疾病的患者的血液中清除溶质的装置，以及包括血液滤过器的单个过滤器，用于从患者抽取血液并将血液推进混合室的血泵，混合和 血液和非等渗稀释剂混合并被允许接近或达到平衡（关于溶质浓度）的拘留室，用于在混合/滞留室中产生湍流的混合元件，以及用于携带泵送血液的适当管道 来自专利。 还公开了利用该装置的方法。

公开(公告)号：US06566084B1

公开(公告)日：2003-05-20

申请号：US09567021

申请日：2000-05-09

申请人： Donald W. Landry ,  Kang Zhao

发明人： Donald W. Landry ,  Kang Zhao

IPC分类号： G01N3353

CPC分类号： C07D451/02 ,  A61K38/00 ,  A61K47/6803 ,  C07F9/6561 ,  C07F9/657172 ,  C07F9/6584 ,  C07K16/44 ,  C12N9/0002

摘要： This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmaceutical composition for decreasing cocaine concentration in a subject using the antibodies produced.

摘要翻译： 本发明提供了类似于可卡因苯甲酰酯基的水解转变状态的化合物。 本发明还提供了与载体蛋白质及其抗体连接的类似物。 本发明还提供了使用所产生抗体降低受试者中可卡因浓度的药物组合物。

公开(公告)号：US20210047337A1

公开(公告)日：2021-02-18

申请号：US17085791

申请日：2020-10-30

申请人： Konstantin Petrukhin ,  Kirsten Alison Rinderspacher ,  Shi-Xian Deng ,  Andras Varadi ,  Boglarka Racz ,  Peter Bernstein ,  Patricia C. Weber ,  Donald W. Landry ,  Andrew S. Wasmuth

发明人： Konstantin Petrukhin ,  Kirsten Alison Rinderspacher ,  Shi-Xian Deng ,  Andras Varadi ,  Boglarka Racz ,  Peter Bernstein ,  Patricia C. Weber ,  Donald W. Landry ,  Andrew S. Wasmuth

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P27/02

摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, C1-C4 alkyl, aryl or heteroaryl; X is N or CR6, wherein R6 is H, OH, or halogen; A is absent or present, and when present is B has the structure: or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20170106056A1

公开(公告)日：2017-04-20

申请号：US15390514

申请日：2016-12-25

申请人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovic ,  John J. Tesmer ,  Remy L. Brim

发明人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovic ,  John J. Tesmer ,  Remy L. Brim

IPC分类号： A61K38/46 ,  C12N9/18 ,  C12Q1/44 ,  A61K9/00

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K31/505 ,  A61K45/06 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  C12N9/18 ,  C12Q1/44 ,  C12Y301/01084 ,  G01N2333/918 ,  A61K2300/00

摘要： Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.