利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

281 条记录 (耗时 0.055 秒)

    Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
    31.
    发明授权
    Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds 失效
    吡咯并吡啶，吡咯并嘧啶和相关的杂环化合物

    公开(公告)号：US08633193B2

    公开(公告)日：2014-01-21

    申请号：US13014066

    申请日：2011-01-26

    申请人： Jun Yuan ,  Peter Hrnciar ,  Qin Guo ,  George D. Maynard

    发明人： Jun Yuan ,  Peter Hrnciar ,  Qin Guo ,  George D. Maynard

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P37/00 ,  A61P37/06 ,  A61P11/06 ,  A61P17/06

    CPC分类号： C07D471/04

    摘要： Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R2, R5, E, Z1, Z3, Z4, and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.

    摘要翻译： 吡咯并 - 吡啶，吡咯并 - 嘧啶和相关的杂环化合物，其分子式如下：其中R，R 2，R 5，E，Z 1，Z 3，Z 4和Ar如本文所定义。 这些化合物是C5a受体的配体。 本发明优选的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物以高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。 此外，本发明提供了标记的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物，其可用作C5a受体定位的探针。

    Heteroaryl amide derivatives
    34.
    发明授权
    Heteroaryl amide derivatives 失效
    杂芳酰胺衍生物

    公开(公告)号：US08431593B2

    公开(公告)日：2013-04-30

    申请号：US12516480

    申请日：2007-11-27

    申请人： Alan J. Hutchison ,  Hongbin Li ,  Jianmin Mao ,  David J. Wustrow ,  Jun Yuan ,  He Zhao

    发明人： Alan J. Hutchison ,  Hongbin Li ,  Jianmin Mao ,  David J. Wustrow ,  Jun Yuan ,  He Zhao

    IPC分类号： A61K31/44 ,  A01N43/42 ,  C07D221/02

    CPC分类号： C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/113 ,  C07D519/00

    摘要： Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

    摘要翻译： 提供了以下分子式的杂芳酰胺衍生物：其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

    Dynamic sourcing
    35.
    发明授权
    Dynamic sourcing 有权
    动态采购

    公开(公告)号：US08296287B1

    公开(公告)日：2012-10-23

    申请号：US12907494

    申请日：2010-10-19

    申请人： Scott Cappiello ,  Xun Feng ,  Yuliyan Kiryakov ,  Jun Yuan

    发明人： Scott Cappiello ,  Xun Feng ,  Yuliyan Kiryakov ,  Jun Yuan

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30592 ,  G06F17/30457

    摘要： Dynamic sourcing, in which a data request that is associated with a query is received and a parameter of data needed for satisfaction of the query is identified. Parameter information defining data available in at least one cube stored in a cache is accessed and the parameter is compared with the parameter information. Based on comparison results, it is determined whether one or more cubes in the cache include sufficient data to satisfy the query. In response to a determination that one or more cubes include sufficient data to satisfy the query, a response to the data request is generated by executing the query against the one or more cubes. In response to a determination that the cubes do not include sufficient data to satisfy the query, a response to the data request is generated by executing at least a portion of the query against a database system.

    摘要翻译： 动态采购，其中接收到与查询相关联的数据请求，并且识别满足查询所需的数据参数。 访问定义存储在高速缓存中的至少一个立方体中可用的数据的参数信息，并将参数与参数信息进行比较。 基于比较结果，确定高速缓存中的一个或多个立方体是否包含足以满足查询的数据。 响应于确定一个或多个立方体包括足够的数据以满足查询，通过针对一个或多个立方体执行查询来生成对数据请求的响应。 响应于确定立方体不包括足够的数据以满足查询，通过针对数据库系统执行查询的至少一部分来生成对数据请求的响应。

    Differential Encoding With Adaptive Resetting
    37.
    发明申请
    Differential Encoding With Adaptive Resetting 审中-公开
    具有自适应复位的差分编码

    公开(公告)号：US20120066564A1

    公开(公告)日：2012-03-15

    申请号：US12806208

    申请日：2009-09-02

    申请人： Hosein Nikopourdeilami ,  Jun Yuan ,  Mo-Han Fong ,  Mohammadhadi Baligh

    发明人： Hosein Nikopourdeilami ,  Jun Yuan ,  Mo-Han Fong ,  Mohammadhadi Baligh

    IPC分类号： G06F11/10

    CPC分类号： H04L1/0681

    摘要： To feedback MIMO channel conditions, a codeword from a codebook is selected. To reduce signalling, the codewords are organized into codeword subsets. The receiver signals an index of a codeword into a current 5 codeword subset previously made known to the transmitter. The current codeword subset is adaptively selected based on a threshold criterion. For example, if the best codeword from the current codeword subset is not sufficiently similar to the best codeword in the full codebook, a switch in the codeword subset is made.

    摘要翻译： 为了反馈MIMO信道条件，选择来自码本的码字。 为了减少信令，码字被组织成码字子集。 接收机将码字的索引发送到先前对发射机已知的当前5码字子集。 基于阈值标准自适应地选择当前码字子集。 例如，如果来自当前码字子集的最佳码字不足以与完整码本中的最佳码字相似，则在码字子集中进行切换。

    METHODS OF POWER SHARING FOR DL CONTROL TRANSMISSION
    39.
    发明申请
    METHODS OF POWER SHARING FOR DL CONTROL TRANSMISSION 审中-公开
    用于DL控制传输的功率共享方法

    公开(公告)号：US20110130165A1

    公开(公告)日：2011-06-02

    申请号：US12589547

    申请日：2009-07-06

    申请人： Jun Yuan ,  Mo-Han Fong

    发明人： Jun Yuan ,  Mo-Han Fong

    IPC分类号： H04W52/04

    CPC分类号： H04W52/346 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/0015 ,  H04L1/0026 ,  H04L1/0618 ,  H04W72/0473 ,  H04W84/047

    摘要： A method of optimizing downlink communications between a base station and mobile stations in a wireless communication system involves: identifying users that have a modulation control scheme (MCS) power value greater than a reference power value as high power users; for each of the high power users, calculating a power difference being a difference between a geometry value associated with each of the high power users and a reference geometry value associated with the reference power value respectively; summing the power differences in a power pool; identifying users that have an MCS power value below the reference power value as low power users; associating increased geometry values with at least some of the low power users while depleting the power pool by corresponding amounts until the power pool is depleted; and determining new MCSs for at least some of the low power users based on the increased geometry values.

    摘要翻译： 一种在无线通信系统中优化基站与移动台之间的下行链路通信的方法，包括：将具有大于参考功率值的调制控制方案（MCS）功率值的用户识别为高功率用户; 对于每个高功率用户，计算功率差是与每个高功率用户相关联的几何值之间的差异以及与参考功率值相关联的参考几何值; 总结电力系统的功率差异; 将具有低于参考功率值的MCS功率值的用户识别为低功率用户; 将增加的几何值与至少一些低功率用户相关联，同时在功率池耗尽之前将功率池耗尽相应的量; 以及基于所增加的几何值来为至少一些所述低功率用户确定新的MCS。

    METHOD AND SYSTEM FOR IMPROVING PERFORMANCE OF A POSITIONING SYSTEM DURING A CONTINUOUS POSITIONING PROCESS (As Amended)
    40.
    发明申请
    METHOD AND SYSTEM FOR IMPROVING PERFORMANCE OF A POSITIONING SYSTEM DURING A CONTINUOUS POSITIONING PROCESS (As Amended) 有权
    在连续定位过程中改进定位系统的性能的方法和系统（如修改）

    公开(公告)号：US20110117936A1

    公开(公告)日：2011-05-19

    申请号：US13055743

    申请日：2009-09-22

    申请人： Jun Yuan

    发明人： Jun Yuan

    IPC分类号： H04W64/00

    CPC分类号： G01S5/0205 ,  H04L67/04 ,  H04W8/24 ,  H04W64/00

    摘要： A method and system for improving performance of a positioning system during a continuous positioning process. The method is applied in a mobile communication positioning system, and mainly comprises the following steps: during the continuous positioning process, a mobile positioning center sends a mobile station state inquiring request to a home location register, the home location register receives the request and returns a mobile station current state response, the mobile positioning center performs positioning process or terminates positioning process to the mobile station based on the current state of the station. The present method can avoid circumstances where the continuous positioning has terminated while the positioning center and the positioning entity fails to release resources in time. Also, it can continuously track a subscriber in special industrial application, which avoids the circumstance of inability to continue previous continuous positioning after restart of a subscriber terminal.

    摘要翻译： 一种用于在连续定位过程中改善定位系统的性能的方法和系统。 该方法应用在移动通信定位系统中，主要包括以下步骤：在连续定位过程中，移动定位中心向归属位置寄存器发送移动台状态查询请求，归属位置寄存器接收请求并返回 移动台当前状态响应，移动定位中心根据站的当前状态，对移动台执行定位处理或终止定位处理。 本方法可以避免在定位中心和定位实体无法及时释放资源的情况下连续定位终止。 此外，它可以在特殊工业应用中连续跟踪用户，这避免了在重新启动用户终端之后无法继续先前的连续定位的情况。