公开(公告)号：US09423383B2

公开(公告)日：2016-08-23

申请号：US14275334

申请日：2014-05-12

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/46 ,  G01N30/60 ,  G01N30/72

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

摘要翻译： 本文所述的某些实施方案涉及包括微流体装置的色谱系统。 微流体装置可以流体耦合到切换阀，以提供色谱系统中流体流动的选择性控制。 在一些示例中，微流体装置可以包括充电室，旁路限流器或可以提供对系统中的流体流的附加控制的其它特征。 还描述了使用这些装置的方法和计算长度和直径以提供期望流速的方法。

公开(公告)号：US20150268137A1

公开(公告)日：2015-09-24

申请号：US14634856

申请日：2015-03-01

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N1/22 ,  G01N27/62 ,  G01N30/28

CPC分类号： G01N1/2226 ,  G01N27/626 ,  G01N30/28 ,  G01N2001/2229 ,  G01N2030/025

摘要： Certain embodiments described herein are directed to devices, systems and methods that are configured to control flow of an explosive carrier gas in a sampling system. In some examples, a flow control device configured to provide release of explosive carrier gas in less than an explosive amount to void space in the sampling system is described. Systems and methods using the flow control device are also disclosed.

摘要翻译： 本文描述的某些实施例涉及被配置为控制采样系统中的爆炸载气的流动的装置，系统和方法。 在一些示例中，描述了一种流量控制装置，其构造成以小于爆炸量的爆炸载体气体释放到采样系统中的空隙空间。 还公开了使用流量控制装置的系统和方法。

公开(公告)号：US08297107B2

公开(公告)日：2012-10-30

申请号：US11751327

申请日：2007-05-21

申请人： Andrew Tipler ,  Richard G. Edwards ,  Michael Paul Dinsmore

发明人： Andrew Tipler ,  Richard G. Edwards ,  Michael Paul Dinsmore

IPC分类号： G01N30/04

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本上恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US08182768B2

公开(公告)日：2012-05-22

申请号：US11251187

申请日：2005-10-14

申请人： Andrew Tipler ,  John H. Vanderhoef ,  James E. Botelho

发明人： Andrew Tipler ,  John H. Vanderhoef ,  James E. Botelho

IPC分类号： G01N30/02

CPC分类号： G01N30/16 ,  G01N35/1095 ,  G01N2030/085 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

摘要： A system for interfacing a sampling device and a chromatograph and for pre-concentrating analytes in a sample prior to introducing the sample into the chromatographic column is generally disclosed comprising an interface housing with a first channel and an adsorbent housing with a second channel, which contains at least one adsorbent. Valveless conduits permit fluid to be communicated between the sampling device and the first channel, between the first channel and the second channel, and the first channel and the column. In some embodiments, fluid flows in one direction when the analytes are adsorbed and in the opposite direction when analytes are desorbed. In certain embodiments, two different adsorbents are disposed in the second channel to adsorb different types of analytes.

摘要翻译： 通常公开了用于在将样品引入色谱柱之前将取样装置和色谱仪连接并用于预先浓缩样品中的分析物的系统，其包括具有第一通道的界面壳体和具有第二通道的吸附剂壳体，其包含 至少一种吸附剂。 无阀管道允许流体在采样装置和第一通道之间，第一通道和第二通道之间以及第一通道和塔之间连通。 在一些实施方案中，当分析物被吸附时，流体沿一个方向流动，并且当分析物被解吸时在相反方向流动。 在某些实施方案中，两个不同的吸附剂设置在第二通道中以吸附不同类型的分析物。

公开(公告)号：US08017081B2

公开(公告)日：2011-09-13

申请号：US12262907

申请日：2008-10-31

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N7/00

CPC分类号： G01K11/00 ,  G01K11/02 ,  Y10T436/25875

摘要： A system and method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.

摘要翻译： 提供一种测量具有顶部空间的密封容器内的有效温度的系统和方法。 将液体溶剂加入到容器中，并将固体化合物加入到液体溶剂中以产生饱和溶液。 允许饱和溶液的蒸气在密封容器的顶部空间中平衡，并将其体积转移到色谱柱，其中取平衡蒸气的色谱读数。 然后基于平衡蒸气的色谱读数计算密封容器内的温度，其中温度计算基于平衡蒸气中的液体溶剂和固体化合物的浓度。

公开(公告)号：US07709267B2

公开(公告)日：2010-05-04

申请号：US11251310

申请日：2005-10-14

申请人： Andrew Tipler ,  Christopher Mazza

发明人： Andrew Tipler ,  Christopher Mazza

IPC分类号： G01N30/24 ,  G01N1/22 ,  G01N35/10 ,  G01N30/02 ,  G01N30/08

CPC分类号： G01N1/2226 ,  G01N30/06 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/25875 ,  G01N30/32 ,  G01N2030/405

摘要： A system and method for extracting headspace vapor is generally disclosed comprising pressurizing a vessel containing headspace vapor with a carrier gas and subsequently venting the sample mixture through an adsorbent trap and out a vent. A flow controller is employed to gradually increase the flow therethrough as the pressure drops as a result of the gradual depletion of headspace vapor in the vessel and, in certain embodiments, the flow controller maintains a constant flow rate. Due to the time saved, in some embodiments, multiple pressurization-venting cycles are implemented to maximize the amount of vapor extracted from the vial. Due to the constant flow rate, in certain embodiments, the pressure decay is monitored and compared to reference values in order to determine whether the sample vessel has a leak or other defect.

摘要翻译： 通常公开了一种用于提取顶空蒸气的系统和方法，包括用载气加压含有顶空蒸气的容器，随后将样品混合物通过吸附剂阱并排出出口。 采用流量控制器随着压力下降而逐渐增加流量，这是由于容器中顶部空气蒸气逐渐消耗的结果，并且在某些实施例中，流量控制器保持恒定的流速。 由于节省了时间，在一些实施例中，实施多个加压 - 排气循环以最大化从小瓶中提取的蒸气的量。 由于恒定的流速，在某些实施例中，监测压力衰减并与参考值进行比较，以确定样品容器是否具有泄漏或其他缺陷。

公开(公告)号：US07572319B2

公开(公告)日：2009-08-11

申请号：US11963938

申请日：2007-12-24

申请人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

发明人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

IPC分类号： B01D53/22

CPC分类号： B01D53/025 ,  B01D2253/102 ,  G01N30/12 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/127 ,  G01N2030/128

摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube packed with an adsorbent, wherein the tube may serve as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.

摘要翻译： 公开了用于气相色谱的分析物预浓缩器，其通常包括填充有吸附剂的管，其中该管可用作色谱注射器的衬垫，作为与色谱柱耦合的吸附阱，和/或作为吸附阱捕获 到顶空进样器。 优选地，加热装置允许管被加热。 在优选实施方案中，分析物预浓缩器还包括柱分离附件，使得色谱柱可以暂时与流过管的物质隔离。

公开(公告)号：US07459313B2

公开(公告)日：2008-12-02

申请号：US10621942

申请日：2003-07-17

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N7/00

CPC分类号： G01K11/00 ,  G01K11/02 ,  Y10T436/25875

摘要： A method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.

摘要翻译： 提供一种测量具有顶部空间的密封容器内的有效温度的方法。 将液体溶剂加入到容器中，并将固体化合物加入到液体溶剂中以产生饱和溶液。 允许饱和溶液的蒸气在密封容器的顶部空间中平衡，并将其体积转移到色谱柱，其中取平衡蒸气的色谱读数。 然后基于平衡蒸气的色谱读数计算密封容器内的温度，其中温度计算基于平衡蒸气中的液体溶剂和固体化合物的浓度。

公开(公告)号：US20070261474A1

公开(公告)日：2007-11-15

申请号：US11751327

申请日：2007-05-21

申请人： Andrew Tipler ,  Richard Edwards ,  Michael Dinsmore

发明人： Andrew Tipler ,  Richard Edwards ,  Michael Dinsmore

IPC分类号： G01N30/26

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US07219532B2

公开(公告)日：2007-05-22

申请号：US11189467

申请日：2005-07-26

申请人： Andrew Tipler ,  Richard G. Edwards

发明人： Andrew Tipler ,  Richard G. Edwards

IPC分类号： G01N30/04

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。