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31.发明申请UREA-AND URETHANE-SUBSTITUTED ACYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE 有权尿素和尿素取代的精油，其制备方法及其使用公开(公告)号：US20080033042A1
公开(公告)日：2008-02-07
申请号：US11845242
申请日：2007-08-27
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： A61K31/16 , A61K31/24 , A61P3/00 , A61P5/00 , C07C229/38 , C07C233/37
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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32.发明授权Urea- and urethane-substituted acylureas, process for their preparation and their use 有权尿素和氨基甲酸酯取代的酰基脲，其制备方法及其用途公开(公告)号：US07262220B2
公开(公告)日：2007-08-28
申请号：US10616959
申请日：2003-07-11
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： C07C275/24 , A61K31/277
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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33.发明授权Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use 有权取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用公开(公告)号：US07196114B2
公开(公告)日：2007-03-27
申请号：US10780344
申请日：2004-02-17
申请人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
发明人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
IPC分类号： A61K31/38 , C07D333/36
CPC分类号： C07D409/04 , C07D333/36 , C07D333/38 , C07D333/44 , C07D413/04
摘要： Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their useThe invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译： 取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用
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34.发明申请Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050182087A1
公开(公告)日：2005-08-18
申请号：US11042770
申请日：2005-01-25
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
IPC分类号： A61K31/47 , A61K31/4745 , C07D215/36 , C07D471/02
CPC分类号： C07D471/04 , C07D215/36
摘要： Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译： 环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途本发明涉及环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物和生理学上 耐受的盐及其生理功能衍生物。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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35.发明申请Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use 有权羰基氨基取代的酰基苯基脲衍生物，其制备方法及其应用公开(公告)号：US20050014822A1
公开(公告)日：2005-01-20
申请号：US10763877
申请日：2004-01-23
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： C07C275/54 , C07D209/12 , C07D213/82 , C07D295/02 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38 , A61K31/325 , A61K31/17 , A61K31/195 , C07C275/52
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中基团按照规定定义，也涉及其生理上耐受的盐。 该化合物例如可用作预防和治疗2型糖尿病的药物。
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36.发明授权Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 有权羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途公开(公告)号：US06812250B2
公开(公告)日：2004-11-02
申请号：US10153597
申请日：2002-05-24
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
IPC分类号： C07C27516
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.
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37.发明授权Acylphenylurea derivatives, a process for their preparation and their use as pharmaceuticals 有权酰基苯基脲衍生物，其制备方法及其作为药物的用途公开(公告)号：US06506778B2
公开(公告)日：2003-01-14
申请号：US09875901
申请日：2001-06-08
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Heinz Baringhaus
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Heinz Baringhaus
IPC分类号： A61K31445
CPC分类号： C07D295/088 , A61K31/17 , A61K45/06 , C07C275/54 , C07D307/38 , A61K2300/00
摘要： The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and a process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.
摘要翻译： 本发明涉及酰基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了具有所述含义的基团的式Iin化合物及其生理学耐受盐及其制备方法。 该化合物适用于例如用于治疗II型糖尿病。
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38.发明授权Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases 失效取代的丙烷衍生物，其制备方法和用于治疗疾病的化合物的用途
公开(公告)号：US5767141A
公开(公告)日：1998-06-16
申请号：US400952
申请日：1995-03-08
IPC分类号： C07D235/08 , A61K31/415 , A61K31/4184 , A61K31/435 , A61P3/08 , A61P3/10 , C07D235/06 , C07D471/04 , C07D235/02 , C07D235/12 , C07D235/22
CPC分类号： C07D235/06 , C07D471/04
摘要： Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the meanings stated in the description, a process for the preparation of these compounds, their use as pharmaceuticals, and pharmaceutical products are described. Also described are novel intermediates for preparing the compounds of the formula I.
摘要翻译： 取代的丙烷衍生物，其制备方法和用于治疗疾病的化合物的用途式Ⅰ的丙烷衍生物其中基团具有说明书中所述的含义，制备这些化合物的方法，它们的 用作药物，并且描述药物产品。 还描述了制备式I化合物的新型中间体。
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39.发明授权Cyclohexane derivatives, process for their preparation, and the use of the compounds for the treatment of diseases 失效环己烷衍生物，其制备方法以及该化合物用于治疗疾病的用途
公开(公告)号：US5739147A
公开(公告)日：1998-04-14
申请号：US861120
申请日：1997-05-21
IPC分类号： A61K31/435 , A61K31/4353 , A61K31/52 , A61P1/16 , A61P3/08 , A61P3/10 , A61P43/00 , C07D221/00 , C07D235/00 , C07D239/00 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： Cyclohexane derivatives, process for their preparation, and the use of the compounds for the treatment of diseases Cyclohexane derivatives of the formula I ##STR1## wherein R.sup.2, R.sup.4 and R.sup.5 have the given meanings and a process for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as pharmaceuticals.
摘要翻译： 环己烷衍生物，其制备方法以及该化合物用于治疗疾病的用途描述式I的环己烷衍生物，其中R2，R4和R5具有给定的含义及其制备方法。 这些化合物具有有用的药理学特性，因此可以用作药物。
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40.发明授权
公开(公告)号：US5629311A
公开(公告)日：1997-05-13
申请号：US684240
申请日：1996-07-19
IPC分类号： C07D235/08 , A61K31/215 , A61K31/33 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61P3/08 , A61P3/10 , C07C65/36 , C07C69/02 , C07C233/08 , C07C233/90 , C07C255/50 , C07C311/01 , C07C311/02 , C07C311/50 , C07C327/20 , C07C327/38 , C07C327/56 , C07C329/04 , C07C329/14 , C07C333/02 , C07D233/02 , C07D235/04 , C07D235/06 , C07D277/22 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D491/10 , C07D491/113 , C07D493/10 , A61K31/54 , C07D285/24
CPC分类号： C07D235/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D417/04 , C07D417/12 , C07D491/10 , C07D493/10
摘要： Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparationsCyclohexanol esters of the formula I ##STR1## are described in which the radicals have the meaning given herein. The compounds are pharmacologically active and my therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases which are characterized by an elevated secretion of glucose from the liver or by an elevated activity of the glucose-6-phosphatase system.
摘要翻译： 取代的环己醇酯，其用于治疗疾病的用途和药物制剂描述了式I的环己醇酯，其中基团具有本文给出的含义。 这些化合物具有药理活性，因此可以用作药物，特别是用于治疗糖尿病和其它疾病，其特征在于肝脏分泌葡萄糖或葡萄糖-6-磷酸酶系统活性升高。
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