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    CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
    31.
    发明申请
    CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING 有权
    通过破坏PD-1 / PD-L1信号进行癌症免疫治疗

    公开(公告)号：US20130309250A1

    公开(公告)日：2013-11-21

    申请号：US13892671

    申请日：2013-05-13

    Applicant: BRISTOL-MYERS SQUIBB COMPANY

    Inventor： John Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi Tao Wang ,  John M. Wigginton

    IPC: C07K16/28

    CPC classification number: C07K16/2818 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/76 ,  G01N33/57492 ,  G01N2333/70596 ,  G01N2800/52 ,  Y02A50/41 ,  Y02A50/412

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

    Abstract translation: 本公开提供了对患有癌症的受试者的免疫治疗的方法，包括向受试者施用包含治疗有效量的抗体的组合物，其抑制来自PD-1 / PD-L1信号传导途径的信号传导。 本公开还提供了对患有癌症的受试者进行免疫治疗的方法，包括选择作为免疫治疗的合适候选者的受试者，其基于评估来自在细胞上表达PD-L1的受试者的测试组织样品中的细胞比例 表面超过预定阈值水平，并向所选受试者施用治疗有效量的抗PD-1抗体。 本发明另外提供了与FFPE组织样品中的细胞表面表达的PD-L1抗原特异性结合的兔mAb，以及使用所提供的抗PD-L1抗体评价FFPE组织中的细胞表面表达的自动化IHC方法。

    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
    33.
    发明授权
    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling 有权

    公开(公告)号：US10584170B2

    公开(公告)日：2020-03-10

    申请号：US16248215

    申请日：2019-01-15

    Applicant: Bristol-Myers Squibb Company

    Inventor： John P. Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi-Tao Wang ,  Jon M. Wigginton

    IPC: C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  A61K39/00

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
    34.
    发明授权
    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling 有权

    公开(公告)号：US10323093B2

    公开(公告)日：2019-06-18

    申请号：US16230657

    申请日：2018-12-21

    Applicant: Bristol-Myers Squibb Company

    Inventor： John P. Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi-Tao Wang ,  Jon M. Wigginton

    IPC: C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  A61K39/00

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
    35.
    发明授权
    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling 有权

    公开(公告)号：US10323092B2

    公开(公告)日：2019-06-18

    申请号：US16006493

    申请日：2018-06-12

    Applicant: Bristol-Myers Squibb Company

    Inventor： John P. Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi-Tao Wang ,  Jon M. Wigginton

    IPC: C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  A61K39/00

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
    36.
    发明授权
    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling 有权

    公开(公告)号：US10308714B2

    公开(公告)日：2019-06-04

    申请号：US16024340

    申请日：2018-06-29

    Applicant: Bristol-Myers Squibb Company

    Inventor： John P. Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi-Tao Wang ,  Jon M. Wigginton

    IPC: C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  A61K39/00

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
    38.
    发明授权
    Cancer immunotherapy by disrupting PD-1/PD-L1 signaling 有权

    公开(公告)号：US10266594B1

    公开(公告)日：2019-04-23

    申请号：US16213954

    申请日：2018-12-07

    Applicant: Bristol-Myers Squibb Company

    Inventor： John P. Cogswell ,  Stacie M. Goldberg ,  Ashok K. Gupta ,  Maria Jure-Kunkel ,  Xi-Tao Wang ,  Jon M. Wigginton

    IPC: C07K16/28 ,  G01N33/574 ,  C07K16/18 ,  A61K39/395 ,  A61K39/00

    Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

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