公开(公告)号：US20150353932A1

公开(公告)日：2015-12-10

申请号：US14297484

申请日：2014-06-05

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/117

CPC classification number: C12N15/115 ,  C12N15/117 ,  C12N2310/16 ,  C12N2310/17 ,  C12N2320/13

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract translation: 本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。 本发明还涉及与靶分子具有亲和力结合的功能性配体。

公开(公告)号：US11970785B2

公开(公告)日：2024-04-30

申请号：US17460513

申请日：2021-08-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Alexander S. Chiu ,  Rafal Drabek ,  Deepak Thirunavukarasu ,  Caitlin Bruns

IPC: C07H21/04 ,  C12Q1/6811 ,  C12Q1/6837 ,  C40B40/06

CPC classification number: C40B40/06 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q1/6811 ,  C12Q2525/205 ,  C12Q2525/301 ,  C12Q2537/143 ,  C12Q2563/159 ,  C12Q2565/101 ,  C12Q2565/501 ,  C12Q1/6837 ,  C12Q2525/205 ,  C12Q2525/301 ,  C12Q2537/143 ,  C12Q2563/159 ,  C12Q2565/101

Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.

公开(公告)号：US11725240B2

公开(公告)日：2023-08-15

申请号：US17152007

申请日：2021-01-19

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： Jasmine Kaur ,  Rafal Drabek ,  George W. Jackson ,  Robert Batchelor ,  Alexander Chiu

IPC: C12N15/11 ,  C12Q1/6874 ,  C12N15/115 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

CPC classification number: C12Q1/6874 ,  C12N15/1048 ,  C12N15/115 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04 ,  C12N2310/16 ,  C12N2330/31

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid derivatives.

公开(公告)号：US20230111624A1

公开(公告)日：2023-04-13

申请号：US16625586

申请日：2018-06-20

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12Q1/6811 ,  C12N15/115

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as vitamin C or malaria histidine-rich protein II (HRP2).

公开(公告)号：US11427825B2

公开(公告)日：2022-08-30

申请号：US16488239

申请日：2018-02-28

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Truong Nguyen ,  Rafal Drabek ,  Alexander S. Chiu ,  Deepak Thirunavukarasu ,  Vinoth Sankarapani

IPC: C12N15/115 ,  G01N33/53 ,  G01N33/94

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as drug compounds, such as levamisole and cocaine.

公开(公告)号：US11078489B2

公开(公告)日：2021-08-03

申请号：US15959389

申请日：2018-04-23

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Darryl Bornhop

IPC: C07H21/04 ,  C12N15/115 ,  G01N33/53 ,  G01N21/47 ,  G01N33/542

Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.

公开(公告)号：US10941444B2

公开(公告)日：2021-03-09

申请号：US16262777

申请日：2019-01-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Rafal Drabek ,  Caitlin Bruns

IPC: C12N15/11 ,  C12Q1/6874 ,  C12N15/115 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as lipoarabinomannan (LAM).

公开(公告)号：US10676781B2

公开(公告)日：2020-06-09

申请号：US16006586

申请日：2018-06-12

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/11 ,  C12Q1/6811 ,  C40B40/06 ,  G01N33/94 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as tetrahydrocannabinol (THC).

公开(公告)号：US20200172906A1

公开(公告)日：2020-06-04

申请号：US16677433

申请日：2019-11-07

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： George W. Jackson ,  Robert Batchelor ,  Truong Nguyen ,  Victoria Singer ,  Garam Lee ,  Rafal Drabek

IPC: C12N15/115 ,  C40B10/00 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as molecules used proteins or peptides, such as LL37.

公开(公告)号：US20190242030A1

公开(公告)日：2019-08-08

申请号：US16262825

申请日：2019-01-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Alexander S. Chiu ,  Rafal Drabek ,  Deepak Thirunavukarasu ,  Caitlin Bruns

IPC: C40B40/06

CPC classification number: C40B40/06

Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.