公开(公告)号：US08905334B2

公开(公告)日：2014-12-09

申请号：US13262208

申请日：2010-02-25

申请人： Georg Bachmaier ,  Gerit Ebelsberger ,  Bernhard Fischer ,  Matthias Gerlich ,  Michael Höge ,  Wolfgang Zöls

发明人： Georg Bachmaier ,  Gerit Ebelsberger ,  Bernhard Fischer ,  Matthias Gerlich ,  Michael Höge ,  Wolfgang Zöls

IPC分类号： F16K31/00 ,  F02M61/20 ,  F02M51/00 ,  B05B1/30 ,  F02M51/06 ,  F16K31/122 ,  F16K41/10 ,  F02M61/16

CPC分类号： F02M51/0603 ,  F02M61/167 ,  F16K31/1221 ,  F16K41/10

摘要： A stroke translator or an injector having a solid-state actuator for generating a stroke and a hydraulic system for the hydraulic transmission of the stroke of the solid-state actuator to a control element such as a jet needle of a valve. The hydraulic system has hydraulic volumes hermetically sealed to the outside by metal bellows and constitute a hydraulic bearing with compensation for play. The advantages over known hydraulic levers are such that a complete metal seal is provided, and that a lower-wear design can be realized. Furthermore, a modular structure can be produced.

摘要翻译： 具有用于产生行程的固态致动器和用于将固态致动器的冲程的液压传递到诸如阀的喷射针的控制元件的液压系统的行程转换器或喷射器。 液压系统具有通过金属波纹管密封到外部的液压容积，并构成具有补偿补偿的液压轴承。 与已知液压杆相比的优点是提供完整的金属密封件，并且可以实现低磨损设计。 此外，可以生产模块化结构。

公开(公告)号：US08754049B2

公开(公告)日：2014-06-17

申请号：US13522204

申请日：2011-01-12

申请人： Bernhard Fischer ,  Rudolf Lucas ,  Susan Tzotzos

发明人： Bernhard Fischer ,  Rudolf Lucas ,  Susan Tzotzos

IPC分类号： A61K38/12 ,  A61K38/00 ,  A61K38/16 ,  A61K38/10 ,  A61K38/04 ,  A61P11/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/525 ,  A61K38/191 ,  C07K7/56

摘要： A cyclic organic compound which comprises 16 amino acids or 17 amino acids and has no carboxyl group C-terminally and/or no amino group N-terminally. Optionally, one of the amino acids is a nonnatural amino acid. The ring closure is formed between a side chain of one amino acid and the C-terminus of another amino acid, or the ring closure is effected with the aid of a nonnatural amino acid. A process for producing and using the compound for regulating vectorial ion channels, for treating diseases associated with the lung function and for treating oedemas is provided.

摘要翻译： 包含16个氨基酸或17个氨基酸并且没有羧基末端和/或没有氨基的N末端的环状有机化合物。 任选地，一个氨基酸是非天然氨基酸。 环闭合在一个氨基酸的侧链和另一个氨基酸的C末端之间形成，或者通过非天然氨基酸进行闭环。 提供了一种用于制备和使用用于调节载体离子通道的化合物，用于治疗与肺功能相关的疾病和用于治疗含水量的方法。

公开(公告)号：US20130261048A1

公开(公告)日：2013-10-03

申请号：US13885705

申请日：2011-11-15

申请人： Bernhard Fischer ,  Rudolf Lucas ,  Hendrik Fischer

发明人： Bernhard Fischer ,  Rudolf Lucas ,  Hendrik Fischer

IPC分类号： C07K7/64

CPC分类号： C07K7/64 ,  A61K38/191 ,  A61K45/06 ,  A61K2300/00

摘要： Described is a composition comprising—a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TX1EX2X3E, where X1, X2 and X3 can be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and—an inhibitor of viral neuraminidase.

摘要翻译： 描述了一种组合物，其包含由7-17个相邻氨基酸组成并包含六聚体TX1EX2X3E的肽，其中X1，X2和X3可以是任何天然或非天然氨基酸，并且肽环化并且不显示TNF 受体结合活性，和病毒神经氨酸酶抑制剂。

公开(公告)号：US20110021411A1

公开(公告)日：2011-01-27

申请号：US12747741

申请日：2008-12-12

申请人： Bernhard Fischer ,  Rudolf Lucas

发明人： Bernhard Fischer ,  Rudolf Lucas

IPC分类号： A61K38/02 ,  C07K14/00 ,  C07K7/08 ,  A61P11/00

CPC分类号： C07K14/525 ,  A61K38/00 ,  C07K2319/00

摘要： A protein which is composed N-terminally of one or several C-terminal parts of the amino acid sequence of the mature tumour necrosis factor and C-terminally of one or several N-terminal parts of the amino acid sequence of the mature tumour necrosis factor, which activates epithelial ion channels and improves the lung function and which can be used for the manufacture of medicaments for the treatment of diseases associated with the lung function, such as oedemas.

摘要翻译： 构成成熟肿瘤坏死因子的氨基酸序列的一个或多个C末端部分的N-末端和成熟肿瘤坏死因子的氨基酸序列的一个或数个N末端部分的C-末端的蛋白质 ，其激活上皮离子通道并改善肺功能，并且其可用于制备用于治疗与肺功能相关的疾病如药物的药物。

公开(公告)号：US20070183949A1

公开(公告)日：2007-08-09

申请号：US11350366

申请日：2006-02-08

申请人： Bernhard Fischer

发明人： Bernhard Fischer

IPC分类号： B01J19/00 ,  B01J8/02 ,  B01F5/06

CPC分类号： B01F5/0475 ,  B01F2215/0098 ,  H01M8/0625 ,  H01M2008/1293

摘要： A hydrocarbon reformer system for a fuel cell system comprising a feedstream delivery unit (FDU) and a hydrocarbon catalytic reformer (CR). The reformer includes a catalyst disposed in a housing. Ahead of the catalyst is the FDU including a static mixer for receiving any or all of air, hydrocarbon fuel, anode tailgas, and steam. The mixer is pleated and perforated, forming a plurality of flow passages between first and second sides of the mixer. Fuel flows through the perforations and is jetted into the reactants at a very large number of flow passage locations, wherein mixing occurs instantly. Homogenized fuel/reactants leave the mixer in a sheet flow nearly uniform in temperature that enters the reformer catalyst and allows uniform catalysis over the entire catalyst surface.

摘要翻译： 一种用于燃料电池系统的烃重整器系统，包括进料流输送单元（FDU）和烃催化重整器（CR）。 重整器包括设置在壳体中的催化剂。 在催化剂之前，FDU包括用于接收任何或全部空气，烃燃料，阳极尾气和蒸汽的静态混合器。 混合器被打褶和穿孔，在混合器的第一和第二面之间形成多个流动通道。 燃料流过穿孔，并在非常大量的流动通道位置处喷射到反应物中，其中立即进行混合。 均质燃料/反应物使混合器在进入重整器催化剂的温度下几乎均匀的片材流中，并允许在整个催化剂表面上均匀催化。

公开(公告)号：US07195182B2

公开(公告)日：2007-03-27

申请号：US11003265

申请日：2004-12-03

申请人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

发明人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

IPC分类号： B05B1/30 ,  B05B1/34 ,  F02M59/00 ,  F02M61/00 ,  F02M47/02

CPC分类号： F02M61/08 ,  F02M51/0603 ,  F02M61/12 ,  F02M61/16 ,  F02M61/168 ,  F02M2200/16

摘要： A dosing device comprises a housing (1) provided with an actuator, a dosing opening (8), a guiding shaft (6) which surrounds part of the valve needle (7) and forms a valve chamber (10) with the same, and a fluid chamber module (4) which is welded to the housing (1) in the form of a duct for guiding the valve needle (7) into the housing (9). The fluid chamber module (4) and the housing (1) are assembled along a separation surface (13) which is subjected to pressure by the dosing liquid and is formed almost only by axial cylinder wall surface parts (13) in order to reduce the pressure load on the weld seam (13).

摘要翻译： 配量装置包括设置有致动器的壳体（1），配量开口（8），围绕阀针（7）的一部分并且形成与其相连的阀室（10）的引导轴（6），以及 流体室模块（4），其以管道形式焊接到壳体（1），用于将阀针（7）引导到壳体（9）中。 流体室模块（4）和壳体（1）沿着分离表面（13）组装，分离表面（13）受到计量液体的压力，几乎仅由轴向气缸壁表面部分（13）形成，以便减少 焊缝上的压力载荷（13）。

公开(公告)号：US20070065687A1

公开(公告)日：2007-03-22

申请号：US11231703

申请日：2005-09-21

申请人： Sean Kelly ,  Bernhard Fischer

发明人： Sean Kelly ,  Bernhard Fischer

IPC分类号： H01M8/06 ,  H01M8/12

CPC分类号： H01M8/04097 ,  H01M8/04022 ,  H01M8/0618 ,  H01M8/0637 ,  H01M2008/1293 ,  Y02E60/566

摘要： In an SOFC stack system, wherein a CPOx reformer supplies reformate to the stack, a portion of the anode tail gas is recycled directly into the anode inlet of the stack, such that the fuel reaching the anodes is a mixture of fresh reformate and recycled anode tail gas and is present at a sufficiently high temperature that endothermic reforming of residual hydrocarbons from the CPOx reformer occurs within the stack. Preferably, an amount of secondary non-reformed fuel is also added to optimize the fuel mixture presented for internal reforming. The anode tail gas is hot, at the stack temperature of 750-800° C., which allows for the mixture of anode tail gas and secondary fuel to be mixed and reacted in a clean-up catalyst to react higher hydrocarbons in the secondary fuel, without additional oxygen, prior to being mixed with reformate and sent to the stack.

摘要翻译： 在SOFC堆叠系​​统中，其中CPOx重整器将重整产物提供给堆叠，一部分阳极尾气直接再循环到堆叠的阳极入口中，使得到达阳极的燃料是新鲜重整产物和再循环阳极的混合物 并且以足够高的温度存在，来自CPOx重整器的残余烃的吸热重整发生在堆内。 优选地，还加入一定量的次级非重整燃料以优化用于内部重整的燃料混合物。 阳极尾气是在750-800℃的叠层温度下是热的，这允许阳极尾气和二次燃料的混合物在清理催化剂中混合和反应，以使第二燃料中的高级烃反应 ，没有额外的氧气，在与重整产物混合并送到堆垛机之前。

公开(公告)号：US07044407B2

公开(公告)日：2006-05-16

申请号：US10428613

申请日：2003-05-02

申请人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Randolf Mock ,  Enrico Ulivieri

发明人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Randolf Mock ,  Enrico Ulivieri

IPC分类号： F02M61/08

CPC分类号： F02M51/0603 ,  F02M61/08 ,  F02M61/16 ,  F02M2200/16

摘要： A fluid dosing device for a pressurized liquid is disclosed, which comprises a chamber (35) which is supplied with pressurized liquid by means of a liquid supply line (17, 19); a valve needle (9) which is guided through the chamber (35), the first end section of said valve needle being able to be lifted and the second end section thereof forming a valve in conjunction with a valve seat disposed on the housing (3). Metal bellows (33) are provided as a leadthrough element for the first end section of the valve needle (9). The metal bellows seal the chamber in said region in a tight manner. A throttle point (37, 39) is provided between the valve needle (9) and the inner wall of the chamber between the metal bellows (33) and the mouth (18) of the liquid supply line (17) leading into the chamber.

摘要翻译： 公开了一种用于加压液体的流体计量装置，其包括通过液体供应管线（17,19）供应加压液体的腔室（35）。 被引导通过所述室（35）的阀针（9），所述阀针的第一端部能够被提升，并且所述第二端部与配置在所述壳体（3）上的阀座一起形成阀 ）。 金属波纹管（33）设置为用于阀针（9）的第一端部的穿通元件。 金属波纹管以紧密的方式密封所述区域中的腔室。 在阀针（9）和金属波纹管（33）与通向腔室的液体供应管线（17）的口（18）之间的腔室内壁处设有节流点（37,39）。

公开(公告)号：US20050103587A1

公开(公告)日：2005-05-19

申请号：US10967384

申请日：2004-10-18

申请人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

发明人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

IPC分类号： F02M51/06 ,  F02M61/08 ,  F02M61/16 ,  F02M61/20 ,  F02M63/00 ,  F16K31/00 ,  F16F5/00

CPC分类号： F02M61/167 ,  F02M51/0603 ,  F02M61/08 ,  F02M2200/16 ,  F16K31/007

摘要： An actuator (4) is connected, on one side, to a valve needle (3), and on the opposite side, to a hydraulic piston (6) pertaining to a hydraulic length compensator. A working chamber (5) is divided by a tight separating membrane (9), into an actuator chamber (10) containing the actuator (4) and a fluid chamber (11) which can be filled with the fluid to be dosed in a pressurized manner while the actuator chamber (10) and the hydraulic chamber (7) are filled with a hydraulic fluid. A base pressure can be produced in the hydraulic fluid by means of the pressure of the fluid to be dosed, which is transmitted through the separating membrane (9).

摘要翻译： 致动器（4）在一侧连接到阀针（3），并且在相对侧连接到与液压长度补偿器相关的液压活塞（6）。 工作室（5）由紧密分隔膜（9）分隔成包含致动器（4）的致动器室（10）和流体室（11），流体室可以填充加压的流体 同时致动器室（10）和液压室（7）填充有液压流体。 在液压流体中可以通过被分配的膜（9）传递的待计量流体的压力产生基础压力。

公开(公告)号：US06676030B2

公开(公告)日：2004-01-13

申请号：US09973933

申请日：2001-10-11

申请人： Jack Lorraine ,  Andreas Kappel ,  Enrico Ulivieri ,  Bernhard Gottlieb ,  Bernhard Fischer

发明人： Jack Lorraine ,  Andreas Kappel ,  Enrico Ulivieri ,  Bernhard Gottlieb ,  Bernhard Fischer

IPC分类号： F02D700

CPC分类号： F02M51/0603 ,  F02M61/08 ,  F02M61/167

摘要： A fuel injector comprises a body having a longitudinal axis, a length-changing actuator that has first and second ends, a closure member coupled to the first end of the length-changing actuator, and a compensator assembly coupled the second end of the actuator. The length-changing actuator includes first and second ends. The closure member is movable between a first configuration permitting fuel injection and a second configuration preventing fuel injection. And the compensator assembly axially positions the actuator with respect to the body in response to temperature variation. The compensator assembly utilizes a configuration of at least one spring disposed between two pistons so as to reduce the use of elastomer seals to thereby reduce a slip stick effect. Also, a method of compensating for thermal expansion or contraction of the fuel injector comprises providing fuel from a fuel supply to the fuel injector; and adjusting the actuator with respect to the body in response to temperature variation.

摘要翻译： 燃料喷射器包括具有纵向轴线的本体，具有第一和第二端的长度改变的致动器，联接到长度改变致动器的第一端的闭合构件和联接在致动器的第二端的补偿器组件。 长度改变致动器包括第一和第二端。 封闭构件可以在允许燃料喷射的第一配置和防止燃料喷射的第二配置之间移动。 并且补偿器组件响应于温度变化将致动器相对于主体轴向定位。 补偿器组件利用设置在两个活塞之间的至少一个弹簧的构造，以便减少弹性体密封的使用，从而减少滑动棒效应。 此外，补偿燃料喷射器的热膨胀或收缩的方法包括从燃料供给燃料喷射器提供燃料; 以及响应于温度变化相对于身体调节致动器。