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公开(公告)号：US20070020675A1
公开(公告)日：2007-01-25
申请号：US11502251
申请日：2006-08-09
申请人： Kenneth Dobie
发明人： Kenneth Dobie
IPC分类号： C12Q1/68 , C07H21/02 , C07F9/6512
CPC分类号： C07H21/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01003 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
摘要翻译： 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。
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公开(公告)号：US20060025373A1
公开(公告)日：2006-02-02
申请号：US11207478
申请日：2005-08-18
申请人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
发明人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
CPC分类号： C07H21/04 , A61K38/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
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公开(公告)号：US20050261216A1
公开(公告)日：2005-11-24
申请号：US10848724
申请日：2004-05-18
申请人： Bridget Lollo , Kenneth Dobie
发明人： Bridget Lollo , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Nanos 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Nanos 1. Methods of using these compounds for modulation of Nanos 1 expression and for diagnosis and treatment of diseases and conditions associated with expression of Nanos 1 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节Nanos1的表达。该组合物包含靶向编码Nanos的核酸的寡核苷酸1.使用这些化合物调节Nanos1表达并用于诊断和治疗与 提供Nanos 1的表达。
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公开(公告)号：US20050196787A1
公开(公告)日：2005-09-08
申请号：US11042899
申请日：2005-01-24
申请人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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35.发明授权公开(公告)号：US08623836B2
公开(公告)日：2014-01-07
申请号：US12953105
申请日：2010-11-23
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
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公开(公告)号：US20070020679A1
公开(公告)日：2007-01-25
申请号：US11527876
申请日：2006-09-26
申请人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
发明人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C07F9/6512
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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公开(公告)号：US20060264395A1
公开(公告)日：2006-11-23
申请号：US10553722
申请日：2004-04-15
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：US07132530B2
公开(公告)日：2006-11-07
申请号：US10633843
申请日：2003-08-04
申请人： C. Frank Bennett , Kenneth Dobie
发明人： C. Frank Bennett , Kenneth Dobie
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
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39.发明申请Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US20050282761A1
公开(公告)日：2005-12-22
申请号：US10927466
申请日：2004-08-25
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
IPC分类号： A61K31/7088 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/72 , C12N20060101 , C12N9/10 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , C07K14/72 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y10T436/143333 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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公开(公告)号：US20050267065A1
公开(公告)日：2005-12-01
申请号：US11136815
申请日：2005-05-24
申请人： Nicholas Dean , Kenneth Dobie , Erich Koller
发明人： Nicholas Dean , Kenneth Dobie , Erich Koller
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12N15/85
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01037 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using these compounds for modulation of Aurora B expression and for diagnosis and treatment of diseases and conditions associated with expression of Aurora B are provided. Also provided are methods of using these compounds to modulate the growth of cancer cells, including p53-deficient cancer cells.
摘要翻译： 提供化合物，组合物和方法用于调节Aurora B的表达。组合物包含靶向编码Aurora B的核酸的寡核苷酸。使用这些化合物调节Aurora B表达并用于诊断和治疗与 提供极光B的表达。 还提供了使用这些化合物调节癌细胞（包括p53缺陷型癌细胞）生长的方法。
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