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1.发明授权公开(公告)号：US08623836B2
公开(公告)日：2014-01-07
申请号：US12953105
申请日：2010-11-23
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
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2.发明申请Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US20050282761A1
公开(公告)日：2005-12-22
申请号：US10927466
申请日：2004-08-25
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
IPC分类号： A61K31/7088 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/72 , C12N20060101 , C12N9/10 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , C07K14/72 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y10T436/143333 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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3.发明申请Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US20060178325A1
公开(公告)日：2006-08-10
申请号：US10547239
申请日：2004-02-27
申请人： George Tachas , Kenneth Dobie , Christopher Belyea , Mark Heffernan , Ravi Jain
发明人： George Tachas , Kenneth Dobie , Christopher Belyea , Mark Heffernan , Ravi Jain
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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公开(公告)号：US20050196787A1
公开(公告)日：2005-09-08
申请号：US11042899
申请日：2005-01-24
申请人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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公开(公告)号：US20070265219A1
公开(公告)日：2007-11-15
申请号：US11691364
申请日：2007-03-26
申请人： C. Bennett , Nicholas Dean , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Nicholas Dean , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/113 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding thyroid hormone receptor interactor 3. Methods of using these compounds for modulation of thyroid hormone receptor interactor 3 expression and for diagnosis and treatment of disease associated with expression of thyroid hormone receptor interactor 3 are provided
摘要翻译： 提供化合物，组合物和方法用于调节甲状腺激素受体相互作用剂3的表达。该组合物包含针对编码甲状腺激素受体相互作用的核酸的寡核苷酸。3.使用这些化合物调节甲状腺激素受体相互作用3表达和 提供了与甲状腺激素受体相互作用3表达相关的疾病的诊断和治疗
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6.发明授权公开(公告)号：US07846906B2
公开(公告)日：2010-12-07
申请号：US10547239
申请日：2004-02-27
申请人： Kenneth Dobie , Ravi Jain
发明人： Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
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公开(公告)号：US20050215506A1
公开(公告)日：2005-09-29
申请号：US11071788
申请日：2005-03-02
申请人： C. Bennett , Thomas Condon , Susan Freier , James Karras , Susan Fitch , Ravi Jain , Kenneth Dobie
发明人： C. Bennett , Thomas Condon , Susan Freier , James Karras , Susan Fitch , Ravi Jain , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
CPC分类号： C07H21/02 , A61K38/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/18001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of tyrosinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding tyrosinase. Methods of using these compounds for modulation of tyrosinase expression and for diagnosis and treatment of disease associated with expression of tyrosinase are provided
摘要翻译： 提供化合物，组合物和方法用于调节酪氨酸酶的表达。 组合物包含靶向编码酪氨酸酶的核酸的寡核苷酸。 提供了使用这些化合物调节酪氨酸酶表达和诊断和治疗与酪氨酸酶表达相关的疾病的方法
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公开(公告)号：US20050181400A1
公开(公告)日：2005-08-18
申请号：US11042768
申请日：2005-01-24
申请人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68 , A61K48/00
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of using these compounds for modulation of eIF4E-BP1 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP1 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP1的表达。 组合物包含靶向编码eIF4E-BP1的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP1表达和用于诊断和治疗与eIF4E-BP1表达相关的疾病和病症的方法。
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公开(公告)号：US20050164254A1
公开(公告)日：2005-07-28
申请号：US11010227
申请日：2004-12-09
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节adipophilin的表达。 组合物包含针对编码脂肪蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节脂肪蛋白表达和用于诊断和治疗与亲脂素表达相关的疾病和病症的方法。
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公开(公告)号：US20060003953A1
公开(公告)日：2006-01-05
申请号：US11004762
申请日：2004-12-03
申请人： C. Bennett , Madeline Butler , Nicholas Dean , Kenneth Dobie , Joshua Finger , Ravi Jain , Robert McKay , Brett Monia , Kathleen Myers
发明人： C. Bennett , Madeline Butler , Nicholas Dean , Kenneth Dobie , Joshua Finger , Ravi Jain , Robert McKay , Brett Monia , Kathleen Myers
CPC分类号： C07H21/04
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中骨生长调节剂的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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