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公开(公告)号：US10172830B2
公开(公告)日：2019-01-08
申请号：US15606154
申请日：2017-05-26
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Jonathan Mark Sutton , Robert Andrew Heald , Andrew Stephen Robert Jennings , Carmelida Capaldi , Elisabetta Armani
IPC: A61K31/4152 , A61K31/4155 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , A61K31/277 , C07D231/44 , C07D249/08 , C07D401/04
Abstract: Pyrazolone derivatives of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of diseases or conditions in which HNE is implicated.
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公开(公告)号：US10117860B2
公开(公告)日：2018-11-06
申请号：US15673710
申请日：2017-08-10
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC: A61K31/444 , A61K31/4545 , A61K31/4436 , C07D453/02 , C07D409/12 , C07D409/14
Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US20170340616A1
公开(公告)日：2017-11-30
申请号：US15673710
申请日：2017-08-10
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Elisabetta Armani , Gabriele Gabriele , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC: A61K31/444 , C07D409/12 , A61K31/4436 , A61K31/4545 , C07D453/02 , C07D409/14
CPC classification number: A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US09763924B2
公开(公告)日：2017-09-19
申请号：US14723964
申请日：2015-05-28
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC: C07D453/02 , A61K31/44 , A61K31/444 , C07D409/12 , A61K31/4545 , A61K31/4436 , C07D409/14
CPC classification number: A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US09487528B2
公开(公告)日：2016-11-08
申请号：US14731786
申请日：2015-06-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta Armani , Carmelida Capaldi , Jonathan Mark Sutton , Robert Andrew Heald
IPC: C07D487/04 , A61K31/519
CPC classification number: C07D487/04 , A61K9/0075 , A61K9/008 , A61K31/519
Abstract: Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.
Abstract translation: 本文所述的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。
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Patent Agency Ranking
36.发明授权Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors 有权1-苯基-2-吡啶基烷基醇的衍生物作为磷酸二酯酶抑制剂公开(公告)号：US09265768B2
公开(公告)日：2016-02-23
申请号：US14164527
申请日：2014-01-27
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Oriana Esposito , Ilaria Peretto
IPC: C07D211/82 , A61K31/435 , A61K31/5377 , C07D213/89 , C07D213/69 , A61K31/44 , A61K31/4439 , A61K31/496 , A61M15/00 , A61M16/14 , C07D213/55 , C07D213/56 , C07D401/12 , C07D413/12 , C07D417/12
CPC classification number: A61K31/5377 , A61K31/44 , A61K31/4439 , A61K31/496 , A61M15/0045 , A61M15/009 , A61M16/14 , C07D213/55 , C07D213/56 , C07D213/69 , C07D213/89 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。
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公开(公告)号：US09199984B2
公开(公告)日：2015-12-01
申请号：US13940555
申请日：2013-07-12
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Carmelida Capaldi , Robert Andrew Heald , Nicholas Charles Ray , Jonathan Mark Sutton
IPC: C07D401/02 , C07D401/10 , C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.
Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。
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公开(公告)号：US09145409B2
公开(公告)日：2015-09-29
申请号：US14560009
申请日：2014-12-04
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Gabriele Amari , Elisabetta Armani , Carmelida Capaldi , Renato De Fanti , Mauro Riccaboni , Charles Baker-Glenn , Hervé Van De Poël
IPC: C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496
CPC classification number: C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Compounds having a benzhydryl structure represented by formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
Abstract translation: 具有本文所述的式（I）表示的二苯甲基结构的化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于治疗呼吸道疾病。
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公开(公告)号：US20140171414A1
公开(公告)日：2014-06-19
申请号：US14108904
申请日：2013-12-17
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Lilian ALCARAZ , Robert Andrew Heald , Jonathan Mark Sutton , Elisabetta Armani , Carmelida Capaldi
IPC: C07D487/04 , C07C309/20 , C07C309/29 , C07D453/02 , C07D487/08
CPC classification number: C07D487/04 , A61K9/0053 , A61K9/007 , C07C47/19 , C07C53/06 , C07C309/04 , C07C309/08 , C07C309/20 , C07C309/29 , C07D453/02 , C07D487/08 , C07D519/00
Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HNE is implicated.
Abstract translation: 本文定义的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。
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40.发明申请1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 有权作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基亚胺醇衍生物公开(公告)号：US20140155391A1
公开(公告)日：2014-06-05
申请号：US14097445
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta ARMANI , Gabriele Amari , Oriana Esposito , Laura Carzaniga , Carmelida Capaldi
IPC: C07D295/155 , A61M15/00 , A61M16/14 , C07D213/89
CPC classification number: C07D295/155 , A61M15/0065 , A61M15/009 , A61M16/14 , C07D213/61 , C07D213/89 , C07D401/12 , C07D407/12 , C07D417/12
Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的过敏性疾病状态或呼吸道疾病。
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