公开(公告)号：US09763924B2

公开(公告)日：2017-09-19

申请号：US14723964

申请日：2015-05-28

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Carmelida Capaldi ,  Wesley Blackaby ,  Ian Linney ,  Hervé Van De Poël ,  Charles Baker-Glenn ,  Naimisha Trivedi

IPC: C07D453/02 ,  A61K31/44 ,  A61K31/444 ,  C07D409/12 ,  A61K31/4545 ,  A61K31/4436 ,  C07D409/14

CPC classification number: A61K31/444 ,  A61K31/4436 ,  A61K31/4545 ,  C07D409/12 ,  C07D409/14 ,  C07D453/02

Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.

公开(公告)号：US09597323B2

公开(公告)日：2017-03-21

申请号：US15168438

申请日：2016-05-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Gabriele Amari ,  Elisabetta Armani ,  Herve Van De Poeol ,  Charles Baker-Glenn ,  Naimisha Trivedi

IPC: A61K31/444 ,  C07D401/12 ,  A61K31/452 ,  C07D453/02

CPC classification number: A61K31/444 ,  A61K31/452 ,  C07D401/12 ,  C07D453/02

Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.

公开(公告)号：US09265768B2

公开(公告)日：2016-02-23

申请号：US14164527

申请日：2014-01-27

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Carmelida Capaldi ,  Oriana Esposito ,  Ilaria Peretto

IPC: C07D211/82 ,  A61K31/435 ,  A61K31/5377 ,  C07D213/89 ,  C07D213/69 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/496 ,  A61M15/00 ,  A61M16/14 ,  C07D213/55 ,  C07D213/56 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: A61K31/5377 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/496 ,  A61M15/0045 ,  A61M15/009 ,  A61M16/14 ,  C07D213/55 ,  C07D213/56 ,  C07D213/69 ,  C07D213/89 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。

公开(公告)号：US09145409B2

公开(公告)日：2015-09-29

申请号：US14560009

申请日：2014-12-04

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Gabriele Amari ,  Elisabetta Armani ,  Carmelida Capaldi ,  Renato De Fanti ,  Mauro Riccaboni ,  Charles Baker-Glenn ,  Hervé Van De Poël

IPC: C07D453/02 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496

CPC classification number: C07D453/02 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds having a benzhydryl structure represented by formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 具有本文所述的式（I）表示的二苯甲基结构的化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于治疗呼吸道疾病。

公开(公告)号：US08748613B2

公开(公告)日：2014-06-10

申请号：US13729388

申请日：2012-12-28

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele Amari ,  Cristina Pesenti ,  Stefano Bossolo

IPC: A01N43/90 ,  A01N43/40 ,  A61K31/44 ,  A61K31/445 ,  C07D453/02 ,  C07D211/00 ,  C07D295/00 ,  C07D401/00 ,  C07D405/00

CPC classification number: C07D453/02 ,  A61K31/439 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/56 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.

Abstract translation: 式（I）化合物：其中A，R 1，R 2，X，m和n如说明书中所定义，是选择性M3受体拮抗剂，并且可用于治疗尤其是呼吸道疾病如哮喘 和COPD。

公开(公告)号：US20140155427A1

公开(公告)日：2014-06-05

申请号：US14097586

申请日：2013-12-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Mauro Riccaboni ,  Andrea Rizzi ,  Charles Baker-Glenn ,  Wesley Blackaby ,  Herve' Van de Poel ,  Ben Whittaker

IPC: C07D453/02 ,  A61K31/444

CPC classification number: C07D453/02 ,  A61K9/0075 ,  A61K31/439 ,  C07D401/12 ,  C07D401/14 ,  C07D453/00

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US20140155391A1

公开(公告)日：2014-06-05

申请号：US14097445

申请日：2013-12-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele Amari ,  Oriana Esposito ,  Laura Carzaniga ,  Carmelida Capaldi

IPC: C07D295/155 ,  A61M15/00 ,  A61M16/14 ,  C07D213/89

CPC classification number: C07D295/155 ,  A61M15/0065 ,  A61M15/009 ,  A61M16/14 ,  C07D213/61 ,  C07D213/89 ,  C07D401/12 ,  C07D407/12 ,  C07D417/12

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的过敏性疾病状态或呼吸道疾病。

公开(公告)号：US20130102576A1

公开(公告)日：2013-04-25

申请号：US13655903

申请日：2012-10-19

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele Amari ,  Carmelida Capaldi ,  Laura Carzaniga ,  Elena La Porta ,  Matilde Guala

IPC: A61K31/4425 ,  C07D401/12 ,  A61K31/4439 ,  C07D473/06 ,  A61K31/522 ,  A61K31/498 ,  A61K31/502 ,  C07D413/14 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/541 ,  A61K31/56 ,  A61P11/00 ,  A61P11/06 ,  A61P37/00 ,  A61P17/00 ,  A61M15/00 ,  A61M11/00 ,  A61M16/14 ,  C07D213/89

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/04

Abstract: Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.

Abstract translation: 化合物，吡啶N-氧化物和式（I）的药学上可接受的盐可用作磷酸二酯酶4（PDE4）酶的抑制剂，并且用于预防和/或治疗以气道阻塞为特征的呼吸道疾病如哮喘或COPD 。