公开(公告)号：US11026792B2

公开(公告)日：2021-06-08

申请号：US16937216

申请日：2020-07-23

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan Kislev ,  Or Cohen ,  Meni Iamberger

IPC: A61F2/24

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

公开(公告)号：US20210145578A1

公开(公告)日：2021-05-20

申请号：US17141853

申请日：2021-01-05

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Meni Iamberger

IPC: A61F2/24

Abstract: A method includes percutaneously advancing an implant to a native heart valve of a subject, the implant being housed in a compressed state within a delivery tool. Next, the method includes unhousing a longitudinally-intermediate portion of the implant, the longitudinally-intermediate portion being longitudinally between a longitudinally-proximal portion of the implant and a longitudinally distal portion of the implant. Subsequently, the longitudinally-proximal portion of the implant is unhoused. Subsequently, the longitudinally-distal portion of the implant is unhoused. Other applications are also described.

公开(公告)号：US10856972B2

公开(公告)日：2020-12-08

申请号：US16136110

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: Prosthetic valves and methods of implanting prosthetic valves may be provided, including a prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms, and a plurality of ventricular anchoring legs. The arms and legs may extend radially outward from the annular valve body and may each include a native valve tissue engaging portion. The arms may be angularly offset from the legs, with the tissue engaging portion of each arm and each leg arranged such that when the arms and legs are positioned on opposing sides of native heart valve tissue, the native heart valve tissue may assume a serpentine arrangement between the arms and the legs.

公开(公告)号：US10575948B2

公开(公告)日：2020-03-03

申请号：US15956956

申请日：2018-04-19

Applicant: CARDIOVALVE LTD.

Inventor： Meni Iamberger ,  Aviram Baum ,  Ilia Hariton ,  Yelena Kasimov

IPC: A61F2/24 ,  B29C39/10 ,  B29C39/00 ,  B29L31/40 ,  B29K83/00

Abstract: A frame assembly includes a valve body, a plurality of arms that each extend radially outward from the valve body to a respective arm-tip, and a plurality of ventricular legs that are coupled to the valve body and that extend radially outward from the valve body and toward the plurality of arms. A liner lines the lumen. Prosthetic leaflets are attached to the liner within the lumen. A first sheet of flexible material is attached to the plurality of arms. A second sheet of flexible material is attached to the first sheet and extends radially inwards and downstream, and is attached to the valve body. The first sheet, the second sheet, and the liner define an inflatable pouch therebetween. The apparatus defines a plurality of windows from the lumen into the pouch.

公开(公告)号：US20190083245A1

公开(公告)日：2019-03-21

申请号：US16135663

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body, and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The arms may be configured to engage an atrial portion of the native mitral valve and the ventricular anchoring legs may be configured to engage a ventricular portion of the native mitral valve. The atrial anchoring arms and the ventricular anchoring legs may be positioned relative to each other such that when the atrial anchoring arms and ventricular anchoring legs engage the native mitral valve, a volume between the atrial anchoring arms and ventricular anchoring legs is configured to be substantially filled with tissue.

公开(公告)号：US20190038404A1

公开(公告)日：2019-02-07

申请号：US15668559

申请日：2017-08-03

Applicant: CARDIOVALVE LTD.

Inventor： Meni Iamberger ,  Aviram Baum ,  Boaz Harari ,  Ilia Hariton

IPC: A61F2/24 ,  A61F2/86

Abstract: A tubular valve body has an upstream end and a downstream end, and has a central longitudinal axis, and defines a lumen along the axis. Prosthetic leaflets are disposed within the lumen, and are configured to facilitate one-way movement of fluid through the lumen in an upstream-to-downstream direction. The valve body has a cellular structure defined by a plurality of joists connected at nodes, the joists and nodes delimiting cells of the cellular structure. The nodes include minor nodes at which 2-4 joists are connected, and major nodes at which 6-8 joists are connected. The cells of the cellular structure comprise a first circumferential row of first-row cells. Each of the first-row cells is connected to each of its circumferentially-adjacent first-row cells at a respective one of the major nodes, and is longitudinally delimited by two of the minor nodes. Other embodiments are described.

公开(公告)号：US12220313B2

公开(公告)日：2025-02-11

申请号：US18109937

申请日：2023-02-15

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: An expandable prosthetic valve is implantable within a native mitral valve by terminal ends of ventricular anchors of the prosthetic valve moving outwardly from a constrained delivery position of the ventricular anchors, while the ventricular anchors are positioned within the atrium. Then, a portion of the expandable prosthetic valve containing the ventricular anchors is advanced through the native mitral valve into the ventricle. Terminal ends of atrial anchors of the prosthetic valve move outwardly relative to a portion of an annular valve body of the prosthetic valve while the atrial anchors are at least partially positioned within the atrium. Next, the annular valve body is radially expanded while the ventricular anchors are in the ventricle and the atrial anchors are in the atrium, thereby anchoring native heart valve tissue between the atrial anchors and ventricular anchors. Other embodiments are also described.

公开(公告)号：US12064347B2

公开(公告)日：2024-08-20

申请号：US18090058

申请日：2022-12-28

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2250/0003 ,  A61F2250/0039

Abstract: A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts arranged in a cellular structure defined by first and second circumferential rows of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. The struts are joined at four corners of the four-side closed cell. Each of the four sides of each of the four-sided closed cells is double-strutted. Other embodiments are also described.

公开(公告)号：US11779458B2

公开(公告)日：2023-10-10

申请号：US17007975

申请日：2020-08-31

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum

IPC: A61F2/24 ,  B23P15/00

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  B23P15/001 ,  A61F2/2436 ,  A61F2210/0014 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2230/0093 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2250/0063

Abstract: A unitary flexible sheet is folded to defines a panel, and first and second tabs. Each of the tabs has an inner layer and an outer layer. First and second prosthetic leaflets are coupled to a tubular frame via the sheet. Each of the leaflets has a respective commissural portion. For each of the commissural portions, a first region of the commissural portion is sandwiched between inner layers of the first and second tabs, and a second region of the commissural portion is disposed flat against the panel. Other embodiments are also described.

公开(公告)号：US11633277B2

公开(公告)日：2023-04-25

申请号：US16760147

申请日：2018-10-21

Applicant: CARDIOVALVE LTD.

Inventor： Maxim Karalnik ,  Or Cohen ,  Michael Albitov ,  Oren Shua ,  Meni Iamberger ,  Ilia Hariton

IPC: A61F2/95 ,  B21D39/04 ,  A61F2/24

Abstract: An assembly (10) for crimping a frame (56) of an implant (58) comprises a crimping device (20) with a base (22) and a crimping mechanism (24) that defines a crimping aperture (26). A bath (28) having a floor (30), and one or more side-walls (32) extending upward from the floor to a side-wall height defines a receptacle (18) that is shaped to receive a portion of the crimping device. The apparatus has an assembled state in which the portion of the crimping device has been received by the receptacle, the crimping device is held securely by the bath, and the aperture is below the side-wall height. Other embodiments are also described.