摘要:
The invention relates to compounds that are spirocyclic azaadamantane derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要:
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin.
摘要:
The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要:
Provided herein are compositions of a class of substituted diazabicycloalkane derivative compounds, which are useful as modulators of nicotinic acetylcholine receptors. The compounds are useful in treating conditions and disorders prevented by, or ameliorated by, nicotinic acetylcholine receptors.
摘要:
The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要:
A kind of portable multimedia network learning machine, includes a microprocessor and a memory connected to the microprocessor, input unit and display, communication and download module, multimedia driving device and multimedia player. The said communication and download module are used for communicating with the calculator connected to the hand-held multimedia network learning machine, uploading effectiveness of instruction message file, and may download multimedia cartoon menu file and multimedia packages in step with teaching in the far end database server, transmit learning situation result to the learning situation receiving terminal. While multimedia driving device and multimedia player are used for driving and playing the said downloaded cartoon menu file and courseware. The present invention also provides a kind of system and method realizing remote information transition between hand-held multimedia network learning machines. The present invention also provides a kind of method for producing multimedia document which can be played in the hand-held multimedia network learning machine. The present invention could expediently produce multimedia document or swap data with remote server.
摘要:
An Orthogonal Frequency Division Multiplexing (OFDM) receiver comprises: a channel estimator receiving a signal that includes a plurality of symbols, each of the symbols including a plurality of pilots and a plurality of data subcarriers, wherein each symbol further includes at least one pilot subcarrier, the estimator using a first channel response estimate of the at least one pilot subcarrier in a first symbol to select a first weight matrix from a plurality of pre-generated weight matrices, and generating channel estimation information for data subcarriers in the first symbol using the selected first weight matrix.
摘要:
The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要:
The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要:
Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.