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公开(公告)号：US20090316112A1
公开(公告)日：2009-12-24
申请号：US12418841
申请日：2009-04-06
申请人： Daniel R. Neal , Leander Zickler
发明人： Daniel R. Neal , Leander Zickler
CPC分类号： G06T5/50 , A61F9/00804 , A61F9/00827 , A61F2009/00848 , A61F2009/00851 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , G06T7/33 , G06T2207/20221 , G06T2207/30041
摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).
摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。 例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的 尝试在完全相同的时间获取图像或其他数据。 有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化 等）。
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32.发明授权公开(公告)号：US07583389B2
公开(公告)日：2009-09-01
申请号：US11783314
申请日：2007-04-09
IPC分类号： G01B11/02
CPC分类号： G01B11/24 , A61B3/1005 , A61B3/107 , G01J9/00 , G01J9/02 , G01M11/0271
摘要： A geometric measurement system is adapted to precisely measure one or more surfaces of objects such as corneas, molds, contact lenses in molds, contact lenses, or other objects in a fixture. The geometric measurement system can employ one or more of three possible methods of measurement: Shack-Hartmann wavefront sensing with wavefront stitching; phase diversity sensing; and white light interferometry.
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公开(公告)号：US07553022B2
公开(公告)日：2009-06-30
申请号：US11829184
申请日：2007-07-27
IPC分类号： A61B3/00
CPC分类号： G01J9/00 , G01B11/306 , G01M11/0257
摘要： A system for mapping a three-dimensional structure includes a projecting optical system adapted to project light onto an object, a correction system adapted to compensate the light for at least one aberration in the object, an imaging system adapted to collect light scattered by the object and a wavefront sensor adapted to receive the light collected by the imaging system and to sense a wavefront of the received light. For highly aberrated structures, a number of wavefront measurements are made which are valid over different portions of the structure, and the valid wavefront data is stitched together to yield a characterization of the total structure.
摘要翻译： 一种用于映射三维结构的系统包括：投影光学系统，其适于将光投射到物体上;校正系统，其适于补偿所述光在所述物体中的至少一个像差;适于收集由所述物体散射的光的成像系统 以及波前传感器，其适于接收由成像系统收集的光并且感测所接收的光的波前。 对于高像差结构，进行了许多波前测量，其在结构的不同部分是有效的，并且有效的波前数据被缝合在一起以产生总结构的表征。
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公开(公告)号：US06607274B2
公开(公告)日：2003-08-19
申请号：US10115037
申请日：2002-04-04
申请人： Keith Stantz , Daniel R. Neal , Ron Rammage
发明人： Keith Stantz , Daniel R. Neal , Ron Rammage
IPC分类号： A61B310
CPC分类号： A61B3/0025
摘要： A method for computing the visual performance of a human or animal subject based on objective measurements of visual refraction, including higher order aberrations, includes measuring wavefront aberrations of a subject ocular pupil, computing a point-spread-function from the measured pupil aberration, providing a test image, and convolving the test image with the point-spread-function. A simulated image may be produced from the convolution result of the test image with the point-spread-function. One or more specific terms of the point-spread-function may be subtracted therefrom prior to the convolving step to simulate an effect of a correcting means, such as spectacles lenses, contact lenses, or laser surgery. A best correction for a given subject may be determined by adjusting the terms that are subtracted to optimize the resultant image.
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公开(公告)号：US5939716A
公开(公告)日：1999-08-17
申请号：US832144
申请日：1997-04-02
申请人： Daniel R. Neal
发明人： Daniel R. Neal
摘要： A system for containing either a reflective particle or a particle having an index of refraction lower than that of the surrounding media in a three-dimensional light cage. A light beam from a single source illuminates an optics system and generates a set of at least three discrete focussed beams that emanate from a single exit aperture and focus on to a focal plane located close to the particle. The set of focal spots defines a ring that surrounds the particle. The set of focussed beams creates a "light cage" and circumscribes a zone of no light within which the particle lies. The surrounding beams apply constraining forces (created by radiation pressure) to the particle, thereby containing it in a three-dimensional force field trap. A diffractive element, such as an aperture multiplexed lens, or either a Dammann grating or phase element in combination with a focusing lens, may be used to generate the beams. A zoom lens may be used to adjust the size of the light cage, permitting particles of various sizes to be captured and contained.
摘要翻译： 一种用于在三维光笼中容纳反射粒子或具有比周围介质的折射率低的折射率的粒子的系统。 来自单个源的光束照射光学系统并且产生一组至少三个离散的聚焦光束，其从单个出射孔发出并聚焦到位于颗粒附近的焦平面上。 焦点集合定义了围绕粒子的环。 聚焦光束集合产生一个“光笼”，并限制了微粒所在的无光区域。 周围的光束施加约束力（由辐射压力产生）到颗粒，从而将其包含在三维力场陷阱中。 可以使用衍射元件，例如孔径复用透镜，或与聚焦透镜组合的达曼光栅或相位元件来产生光束。 可以使用变焦镜头来调节灯笼的尺寸，从而允许捕获并包含各种尺寸的颗粒。
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36.发明授权
公开(公告)号：US5936739A
公开(公告)日：1999-08-10
申请号：US791037
申请日：1997-01-29
CPC分类号： G01N21/4795 , A61B5/0059
摘要： A system for detecting objects in a turbid media utilizes an optical parametric amplifier as an amplifying gate for received light from the media. An optical gating pulse from a second parametric amplifier permits the system to respond to and amplify only ballistic photons from the object in the media.
摘要翻译： 用于检测混浊介质中的物体的系统利用光学参量放大器作为来自介质的接收光的放大门。 来自第二参数放大器的光门控脉冲允许系统仅从介质中的物体响应并放大弹道光子。
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37.发明授权
公开(公告)号：US5493391A
公开(公告)日：1996-02-20
申请号：US273569
申请日：1994-07-11
申请人： Daniel R. Neal , Robert B. Michie
发明人： Daniel R. Neal , Robert B. Michie
CPC分类号： G01J9/00 , G01J2009/002
摘要： A 1-dimensional sensor for measuring wavefront distortion of a light beam as a function of time and spatial position includes a lens system which incorporates a linear array of lenses, and a detector system which incorporates a linear array of light detectors positioned from the lens system so that light passing through any of the lenses is focused on at least one of the light detectors. The 1-dimensional sensor determines the slope of the wavefront by location of the detectors illuminated by the light. The 1 dimensional sensor has much greater bandwidth that 2 dimensional systems.
摘要翻译： 用于测量作为时间和空间位置的函数的光束的波前失真的1维传感器包括结合了线性阵列的透镜的透镜系统和包括从透镜系统定位的光检测器的线性阵列的检测器系统 使得通过任何透镜的光聚焦在至少一个光检测器上。 1维传感器通过由光照射的检测器的位置来确定波前的斜率。 1维传感器具有比2维系统更大的带宽。
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公开(公告)号：US20230148857A1
公开(公告)日：2023-05-18
申请号：US17891083
申请日：2022-08-18
申请人： Daniel R. Neal , Xifeng Zhao , Jeff Kolberg , Ron Rammage
发明人： Daniel R. Neal , Xifeng Zhao , Jeff Kolberg , Ron Rammage
CPC分类号： A61B3/0025 , G16H50/20
摘要： A method for optimizing an ophthalmic treatment, comprising: measuring a patient's eye with an ophthalmic measurement instrument, fabricating a trial correction lens and testing it on the patient's eye, determining a score or success criteria for the trial correction, using the score or success criteria to provide training information to a machine-learning algorithm, and using the machine-learning algorithm to determine an optimal ophthalmic correction.
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公开(公告)号：US20230133703A1
公开(公告)日：2023-05-04
申请号：US17975007
申请日：2022-10-27
申请人： Xifeng Xiao , Daniel R. Neal , Jeff Kolberg , Ron Rammage , Phillip Riera , R. James Copland , Matt Haugo
发明人： Xifeng Xiao , Daniel R. Neal , Jeff Kolberg , Ron Rammage , Phillip Riera , R. James Copland , Matt Haugo
摘要： This invention comprises a combined optical wavefront aberrometer and topographer system that is used in conjunction with a contact lens that has a plurality of fiducial marks disposed on the lens. The fiducial marks are located radially inside of the undilated pupil's diameter. The optical imaging capacity of the aberrometer is used to measure and monitor any misalignments of the contact lens's position (XY decentration) and/or rotation. Image analysis algorithms are used to track the positions of the fiducial marks, and, hence, the amount of geometric misalignment of the contact lens can be calculated. The fiducial marks can comprise micro ink spots, or depressions in the surface of the contact lens (e.g., divots, dimples, pits), or other small surface features, including raised bumps, which can help to stabilize motions of the contact lens on the eye.
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公开(公告)号：US20220370243A1
公开(公告)日：2022-11-24
申请号：US17830281
申请日：2022-06-01
申请人： Daniel R. Neal , R. James Copland , Jeff Kolberg
发明人： Daniel R. Neal , R. James Copland , Jeff Kolberg
IPC分类号： A61F9/008
摘要： Method steps for correcting vision in an eye that uses a customized phakic IOL composing: (1) measuring one or more wavefront aberrations of the eye: (2) designing a wavefront-customized correction profile for an Intraocular Lens (IOL); (3) creating a customized IOL with the customized correction profile; and (4) implanting the customized IOL in the eye. Alternatively, an uncorrected IOL is first implanted and aligned in the eye, followed by in-situ scanning a femtosecond laser spot across the implanted IOL to locally change the Index of Refraction of the IOL material and create an in-situ customized IOL.
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