公开(公告)号：US5597467A

公开(公告)日：1997-01-28

申请号：US391152

申请日：1995-02-21

申请人： Jianzhong Zhu ,  Daniel R. Wiederin

发明人： Jianzhong Zhu ,  Daniel R. Wiederin

IPC分类号： G01N27/447 ,  H01J49/04 ,  H01J49/10 ,  G01N27/26

CPC分类号： H01J49/0431 ,  G01N27/44717 ,  H01J49/105

摘要： A system for interfacing Capillary Zone Electrophoresis (CZE) systems to Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) sample analysis systems is disclosed. The interface system includes a Sample Introduction Electrophoresis Capillary Tube as an integral part of a modified Direct Injection Nebulizer (DIN) system. During use sample components separated by (CZE) are entered to the modified (DIN) via a sample introduction electrophoresis capillary tube present therein, in which modified (DIN) they are mixed with an entered make-up liquid. The make-up liquid is conductive and serves to make electrophoresis effecting electrical contact to the end of the sample introduction electrophoresis capillary tube in the modified (DIN). The resulting mixture of make-up liquid and separated sample components is nebulized by simultaneous ejection of concentric sample component and make-up liquid mixture and an entered gas flow, to provide a multiplicity of small diameter droplets which are typically injected into an Inductively Coupled Plasma Torch for ionization, prior to entry of resulting ionized sample components to a Mass Spectrometer sample analysis system for detection and analysis thereof. It is noted that the presence of the make-up liquid buffers the effect of the entered nebulizing gas flow upon the capillary zone electrophoresis process, thereby allowing decoupled separate optimization of sample separation and nebulizing processes.

摘要翻译： 公开了用于将毛细管区域电泳（CZE）系统与电感耦合等离子体质谱仪（ICP-MS）样品分析系统进行接口的系统。 接口系统包括作为改进的直接喷射雾化器（DIN）系统的组成部分的样品引入电泳毛细管。 在使用期间，通过（CZE）分离的样品组分通过其中存在的样品导入电泳毛细管输入到修饰的（DIN），其中改性（DIN）它们与输入的补充液混合。 补充液是导电性的，用于使电泳与修饰（DIN）中的样品导入电泳毛细管末端电接触。 所得到的补充液体和分离的样品组分的混合物通过同时喷射同心的样品组分和补充液体混合物和输入的气流而喷雾，以提供多个小直径的液滴，其通常被注入到电感耦合等离子体 在将所得离子化样品组分进入质谱仪样品分析系统进行检测和分析前，用于电离的手电筒。 注意，补充液的存在缓冲了进入的雾化气流对毛细管区带电泳过程的影响，从而允许分离和分离样品分离和雾化过程的分离优化。

公开(公告)号：US5400665A

公开(公告)日：1995-03-28

申请号：US025665

申请日：1993-03-03

申请人： Jianzhong Zhu ,  Daniel R. Wiederin ,  John E. Sutton

发明人： Jianzhong Zhu ,  Daniel R. Wiederin ,  John E. Sutton

IPC分类号： G01N1/00 ,  G01N1/14 ,  G01N21/71 ,  H01J49/04 ,  H05H1/42 ,  G01N1/28 ,  B05B1/02 ,  B23K9/00 ,  H01J49/26

CPC分类号： H05H1/42 ,  B23K9/328 ,  G01N21/714 ,  H01J49/04 ,  G01N2001/1463 ,  G01N35/1095

摘要： An efficient sample introduction system and method of use, for accepting liquid sample solutions, nebulizing them to form nebulized sample solution droplets, desolvating and removing solvent therefrom, and introducing the resulting desolvated nebulized sample particles to sample analysis systems is disclosed. In the preferred embodiment a flow of heated gas is caused to flow over the outer surface of a coiled essentially tubular shaped enclosed filter to remove solvent vapor which diffuses through the coiled essentially tubular shaped enclosed filter while a mixture of desolvated nebulized sample particles and solvent vapor is caused to flow therethrough. A modified embodiment utilizes a low temperature condenser in place of the heated gas flow. Nebulization of sample solutions is accomplished by use of high efficiency ultrasonic or direct injection micro nebulizer systems. Desolvation is performed in a desolvation chamber in which heating elements provide a temperature sufficient to vaporize solvent present. The sample introduction system provides improved sample solution nebulization, desolvation and solvent removal, as well as reduced sample loss and carry-over of sample from one analysis procedure to a subsequent analysis procedure, as compared to other systems which perform a similar overall function. The sample introduction system also enhances transport of sample through the sample introduction system to a sample analysis system. The present invention is equally effective with sample solutions in which the sample solvent is either water, or an organic solvent.

摘要翻译： 公开了一种有效的样品引入系统和使用方法，用于接收液体样品溶液，使其雾化以形成雾化的样品溶液液滴，脱溶剂和从中除去溶剂，并将得到的去溶剂化雾化样品颗粒引入样品分析系统。 在优选实施例中，使加热气体的流动流过螺旋状的基本上管状的封闭式过滤器的外表面，以除去溶解蒸气，其通过卷绕的基本管状的封闭过滤器扩散，同时将经脱溶的雾化样品颗粒和溶剂蒸气 使其流过。 改进的实施例使用低温冷凝器来代替加热的气流。 样品溶液的雾化通过使用高效超声波或直接喷射微型雾化器系统来实现。 去溶剂在去溶剂化室中进行，其中加热元件提供足以蒸发存在溶剂的温度。 样品引入系统与执行相似整体功能的其他系统相比，提供了改进的样品溶液雾化，去溶剂化和溶剂去除以及样品从一个分析过程到后续分析过程的样品损失和结转。 样品引入系统还增强样品通过样品引入系统的运输到样品分析系统。 本发明对于其中样品溶剂为水或有机溶剂的样品溶液同样有效。

公开(公告)号：US5393673A

公开(公告)日：1995-02-28

申请号：US252046

申请日：1994-05-31

申请人： Douglas T. Gjerde ,  Daniel R. Wiederin

发明人： Douglas T. Gjerde ,  Daniel R. Wiederin

IPC分类号： G01N1/40 ,  G01N35/08 ,  G01N21/62

CPC分类号： G01N35/08 ,  G01N2001/4016 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/255

摘要： A method detecting the presence or concentration of an analyte in a sample is described in which the sample is mixed with a particulate reagent to form a stable flowable suspension prior to introduction of the sample into an analytical device or detector in order to eliminate memory effects. Preconcentration of the sample bound to the particulate reagent improves sensitivity of the analytical method.

摘要翻译： 描述了检测样品中分析物的存在或浓度的方法，其中将样品与颗粒试剂混合以在将样品引入分析装置或检测器之前形成稳定的可流动悬浮液，以消除记忆效应。 与颗粒试剂结合的样品的预浓缩提高了分析方法的灵敏度。