公开(公告)号：US5597467A

公开(公告)日：1997-01-28

申请号：US391152

申请日：1995-02-21

申请人： Jianzhong Zhu ,  Daniel R. Wiederin

发明人： Jianzhong Zhu ,  Daniel R. Wiederin

IPC分类号： G01N27/447 ,  H01J49/04 ,  H01J49/10 ,  G01N27/26

CPC分类号： H01J49/0431 ,  G01N27/44717 ,  H01J49/105

摘要： A system for interfacing Capillary Zone Electrophoresis (CZE) systems to Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) sample analysis systems is disclosed. The interface system includes a Sample Introduction Electrophoresis Capillary Tube as an integral part of a modified Direct Injection Nebulizer (DIN) system. During use sample components separated by (CZE) are entered to the modified (DIN) via a sample introduction electrophoresis capillary tube present therein, in which modified (DIN) they are mixed with an entered make-up liquid. The make-up liquid is conductive and serves to make electrophoresis effecting electrical contact to the end of the sample introduction electrophoresis capillary tube in the modified (DIN). The resulting mixture of make-up liquid and separated sample components is nebulized by simultaneous ejection of concentric sample component and make-up liquid mixture and an entered gas flow, to provide a multiplicity of small diameter droplets which are typically injected into an Inductively Coupled Plasma Torch for ionization, prior to entry of resulting ionized sample components to a Mass Spectrometer sample analysis system for detection and analysis thereof. It is noted that the presence of the make-up liquid buffers the effect of the entered nebulizing gas flow upon the capillary zone electrophoresis process, thereby allowing decoupled separate optimization of sample separation and nebulizing processes.

摘要翻译： 公开了用于将毛细管区域电泳（CZE）系统与电感耦合等离子体质谱仪（ICP-MS）样品分析系统进行接口的系统。 接口系统包括作为改进的直接喷射雾化器（DIN）系统的组成部分的样品引入电泳毛细管。 在使用期间，通过（CZE）分离的样品组分通过其中存在的样品导入电泳毛细管输入到修饰的（DIN），其中改性（DIN）它们与输入的补充液混合。 补充液是导电性的，用于使电泳与修饰（DIN）中的样品导入电泳毛细管末端电接触。 所得到的补充液体和分离的样品组分的混合物通过同时喷射同心的样品组分和补充液体混合物和输入的气流而喷雾，以提供多个小直径的液滴，其通常被注入到电感耦合等离子体 在将所得离子化样品组分进入质谱仪样品分析系统进行检测和分析前，用于电离的手电筒。 注意，补充液的存在缓冲了进入的雾化气流对毛细管区带电泳过程的影响，从而允许分离和分离样品分离和雾化过程的分离优化。

公开(公告)号：US5400665A

公开(公告)日：1995-03-28

申请号：US025665

申请日：1993-03-03

申请人： Jianzhong Zhu ,  Daniel R. Wiederin ,  John E. Sutton

发明人： Jianzhong Zhu ,  Daniel R. Wiederin ,  John E. Sutton

IPC分类号： G01N1/00 ,  G01N1/14 ,  G01N21/71 ,  H01J49/04 ,  H05H1/42 ,  G01N1/28 ,  B05B1/02 ,  B23K9/00 ,  H01J49/26

CPC分类号： H05H1/42 ,  B23K9/328 ,  G01N21/714 ,  H01J49/04 ,  G01N2001/1463 ,  G01N35/1095

摘要： An efficient sample introduction system and method of use, for accepting liquid sample solutions, nebulizing them to form nebulized sample solution droplets, desolvating and removing solvent therefrom, and introducing the resulting desolvated nebulized sample particles to sample analysis systems is disclosed. In the preferred embodiment a flow of heated gas is caused to flow over the outer surface of a coiled essentially tubular shaped enclosed filter to remove solvent vapor which diffuses through the coiled essentially tubular shaped enclosed filter while a mixture of desolvated nebulized sample particles and solvent vapor is caused to flow therethrough. A modified embodiment utilizes a low temperature condenser in place of the heated gas flow. Nebulization of sample solutions is accomplished by use of high efficiency ultrasonic or direct injection micro nebulizer systems. Desolvation is performed in a desolvation chamber in which heating elements provide a temperature sufficient to vaporize solvent present. The sample introduction system provides improved sample solution nebulization, desolvation and solvent removal, as well as reduced sample loss and carry-over of sample from one analysis procedure to a subsequent analysis procedure, as compared to other systems which perform a similar overall function. The sample introduction system also enhances transport of sample through the sample introduction system to a sample analysis system. The present invention is equally effective with sample solutions in which the sample solvent is either water, or an organic solvent.

摘要翻译： 公开了一种有效的样品引入系统和使用方法，用于接收液体样品溶液，使其雾化以形成雾化的样品溶液液滴，脱溶剂和从中除去溶剂，并将得到的去溶剂化雾化样品颗粒引入样品分析系统。 在优选实施例中，使加热气体的流动流过螺旋状的基本上管状的封闭式过滤器的外表面，以除去溶解蒸气，其通过卷绕的基本管状的封闭过滤器扩散，同时将经脱溶的雾化样品颗粒和溶剂蒸气 使其流过。 改进的实施例使用低温冷凝器来代替加热的气流。 样品溶液的雾化通过使用高效超声波或直接喷射微型雾化器系统来实现。 去溶剂在去溶剂化室中进行，其中加热元件提供足以蒸发存在溶剂的温度。 样品引入系统与执行相似整体功能的其他系统相比，提供了改进的样品溶液雾化，去溶剂化和溶剂去除以及样品从一个分析过程到后续分析过程的样品损失和结转。 样品引入系统还增强样品通过样品引入系统的运输到样品分析系统。 本发明对于其中样品溶剂为水或有机溶剂的样品溶液同样有效。

公开(公告)号：US11054344B2

公开(公告)日：2021-07-06

申请号：US15120897

申请日：2015-02-27

申请人： Elemental Scientific, Inc. ,  David Diaz ,  Jonathan Hein ,  Kyle W. Uhlmeyer ,  Daniel R. Wiederin ,  Tyler Yost ,  Kevin Wiederin

发明人： David Diaz ,  Jonathan Hein ,  Kyle W. Uhlmeyer ,  Daniel R. Wiederin ,  Tyler Yost ,  Kevin Wiederin

IPC分类号： G01N1/00 ,  G01N1/10 ,  G01N1/14 ,  G01N35/00 ,  G01N35/10 ,  H01J49/04

摘要： A system includes an analysis system at a first location and one or more remote sampling systems at a second location remote from the first location. A sampling system can be configured to receive a remote liquid sample. The system also includes a sample transfer line configured to transport gas from the second location to the first location. The sample transfer line is configured to selectively couple with a remote sampling system for supplying a continuous liquid sample segment to the sample transfer line. The system can further include a sample receiving line at the first location. The sample receiving line is configured to selectively couple with the sample transfer line and the analysis system to receive the continuous liquid sample segment and supply the sample to an analysis device.

公开(公告)号：US20210131918A1

公开(公告)日：2021-05-06

申请号：US17046567

申请日：2019-04-09

申请人： Daniel R. Wiederin ,  Kyle W. Uhlmeyer ,  Austin Schultz ,  Jacob Unnerstall ,  Kevin Wiederin

发明人： Daniel R. Wiederin ,  Kyle W. Uhlmeyer ,  Austin Schultz ,  Jacob Unnerstall ,  Kevin Wiederin

IPC分类号： G01N1/14 ,  H01J49/40

摘要： Systems and methods are described to maintain a liquid sample segment of a sample transmitted through a transfer line from a remote sampling to an analysis system. A system, embodiment includes, but is not limited to, a sample transfer line configured to transport a liquid sample from a remote sampling system via gas pressure; a sample loop fluidically coupled with the sample transfer line, the sample loop configured to hold a sample fluid; and a backpressure chamber fluidically coupled with a gas pressure source and with the sample transfer line, the backpressure chamber configured to supply a backpressure against the liquid sample during transport through the sample transfer line.

公开(公告)号：US08847102B2

公开(公告)日：2014-09-30

申请号：US13084208

申请日：2011-04-11

申请人： Daniel R. Wiederin ,  Gary J. Barret

发明人： Daniel R. Wiederin ,  Gary J. Barret

IPC分类号： B23K10/00 ,  H05H1/30

CPC分类号： H05H1/30 ,  G01N21/73

摘要： A demountable plasma torch assembly suitable for use in ICP spectrometry comprises a first tube having an inner diameter and a second tube disposed concentrically within the first tube, wherein the second tube has an outer diameter that is less than the inner diameter of the first tube. The first and second tubes are supported by a torch body. The torch body includes a first bore configured to receive an end of the first tube, a second bore configured to receive an end of the second tube, and a manifold disposed between the first bore and the second bore to receive a gas for injection between the first tube and the second tube. The manifold has an outer diameter at least substantially equal to the inner diameter of the first tube and an inner diameter at least substantially equal to the outer diameter of the second tube.

摘要翻译： 适用于ICP光谱分析的可拆卸等离子体焰炬组件包括具有内径的第一管和同心地设置在第一管内的第二管，其中第二管的外径小于第一管的内径。 第一和第二管由火炬主体支撑。 割炬本体包括构造成容纳第一管的端部的第一孔，构造成容纳第二管的端部的第二孔，以及设置在第一孔和第二孔之间的歧管，以在第二孔之间接收注入气体 第一管和第二管。 歧管具有至少基本上等于第一管的内径的外径和至少基本上等于第二管的外径的内径。

公开(公告)号：US08517722B1

公开(公告)日：2013-08-27

申请号：US12778490

申请日：2010-05-12

申请人： Daniel R. Wiederin

发明人： Daniel R. Wiederin

IPC分类号： F23C7/00

CPC分类号： F23D14/38 ,  F23D91/02

摘要： A torch assembly includes a first tube having opposing first and second ends and a first body structure between the opposing first and second ends. The torch assembly also includes a second tube having opposing first and second ends and a second body structure between the opposing first and second ends. The torch assembly further includes a support jacket. The support jacket includes a support structure. The support structure defines an aperture extending along an axis oriented along a generally longitudinal direction of the support structure. The first tube and the second tube are in a substantially concentric configuration when the second end of the first tube and the second end of the second tube are inserted into the aperture of the support structure.

摘要翻译： 火炬组件包括具有相对的第一和第二端的第一管和在相对的第一和第二端之间的第一主体结构。 割炬组件还包括具有相对的第一和第二端的第二管和在相对的第一和第二端之间的第二主体结构。 火炬组件还包括支撑夹套。 支撑夹套包括支撑结构。 支撑结构限定沿着沿着支撑结构的大致纵向方向定向的轴线延伸的孔。 当第一管的第二端和第二管的第二端插入到支撑结构的孔中时，第一管和第二管是基本同心的构造。

公开(公告)号：US08063337B1

公开(公告)日：2011-11-22

申请号：US11728096

申请日：2007-03-23

申请人： Daniel R. Wiederin

发明人： Daniel R. Wiederin

IPC分类号： B23K9/00 ,  H01J49/00 ,  H01J7/24

CPC分类号： H01J49/105

摘要： An apparatus for use in mass spectrometry comprising an injector body, an injection tube coupled to the injector body, and a shielding assembly disposed between the injector body and the injection tube. The shielding apparatus is suitable for shielding the injector body from heat generated by a plasma source.

摘要翻译： 一种用于质谱法的装置，包括喷射器主体，联接到喷射器主体的喷射管，以及设置在喷射器主体和喷射管之间的屏蔽组件。 屏蔽装置适用于屏蔽喷射器主体免受等离子体源产生的热量。

公开(公告)号：US20110146422A1

公开(公告)日：2011-06-23

申请号：US12644109

申请日：2009-12-22

申请人： Daniel R. Wiederin ,  Gary Barrett

发明人： Daniel R. Wiederin ,  Gary Barrett

IPC分类号： B01L3/00 ,  A47B23/00

CPC分类号： B01L9/06 ,  G01N35/1081 ,  G01N35/109 ,  G01N2035/1086

摘要： A sample tray assembly includes a first tray. The first tray defines a first slot and is disposed on a generally horizontally-oriented plane. The sample tray assembly also includes a second tray adjacent to the first tray. The second tray is configured for translational movement substantially parallel to the generally horizontally-oriented plane of the first tray between a retracted position and an extended position. The second tray defines a second slot. The second slot and the first slot are substantially aligned when the second tray is in the retracted position. The sample tray additionally includes a base member supporting the first tray. The second tray is slidably coupled with the base member.

摘要翻译： 样品盘组件包括第一托盘。 第一托盘限定第一狭槽并且设置在大致水平取向的平面上。 样品托盘组件还包括邻近第一托盘的第二托盘。 第二托盘构造成用于在缩回位置和延伸位置之间基本上平行于第一托盘的大致水平取向的平面的平移运动。 第二托盘限定第二槽。 当第二托盘处于缩回位置时，第二槽和第一槽基本对齐。 样品托盘另外包括支撑第一托盘的基底构件。 第二托盘可滑动地与基座构件连接。

公开(公告)号：US07690275B1

公开(公告)日：2010-04-06

申请号：US11590693

申请日：2006-10-31

申请人： Daniel R. Wiederin ,  David Diaz ,  Gary Barrett

发明人： Daniel R. Wiederin ,  David Diaz ,  Gary Barrett

IPC分类号： G01N1/001

CPC分类号： G01N35/04 ,  G01N35/0099 ,  G01N35/1083 ,  G01N2035/00306 ,  G01N2035/0491 ,  G01N2035/0493

摘要： An enclosure for an automated sampling and/or dispensing device for minimizing contamination to samples enclosed therein. Further, the enclosure may minimize user exposure to the enclosed samples allowing for the containment of potentially hazardous chemicals. In an embodiment, the enclosure includes at least one flexible panel which allows a user to efficiently access the device by retracting the at least one flexible panel. In addition, the at least one flexible panel allows the enclosure to be shipped efficiently for the enclosure may be disassembled into smaller pieces and thus, be shipped in a smaller box when compared to enclosures with non-flexible panels/doors. Moreover, the use of the at least one flexible panel allows the enclosure to be shaped to accommodate varying shaped automated sampling and or dispensing devices and assemblies.

摘要翻译： 用于自动采样和/或分配装置的外壳，用于使包封在其中的样品的污染最小化。 此外，外壳可以最小化使用者暴露于封闭的样品，从而允许容纳潜在的危险化学品。 在一个实施例中，外壳包括至少一个柔性面板，其允许用户通过缩回至少一个柔性面板来有效地访问设备。 此外，与具有非柔性面板/门的外壳相比，至少一个柔性面板允许有效地运送外壳以使外壳可以拆卸成更小的部件，因此与较小的盒子一起运输。 而且，使用至少一个柔性面板允许外壳成形以适应不同形状的自动采样和/或分配装置和组件。

公开(公告)号：US20090217947A1

公开(公告)日：2009-09-03

申请号：US12074052

申请日：2008-02-29

申请人： Daniel R. Wiederin ,  Patrick Sullivan

发明人： Daniel R. Wiederin ,  Patrick Sullivan

IPC分类号： B08B9/027 ,  B08B13/00 ,  B08B7/00

CPC分类号： B08B9/032 ,  B05B7/063 ,  B05B7/066 ,  B05B15/55

摘要： A method for providing rinsing of a nebulizer comprises directing a second rinsing liquid followed by a nebulizing gas to a gas receiving port of the nebulizer through a valve assembly, the valve assembly being connected to a gas transport line configured to transport at least one of the nebulizing gas and the second rinsing liquid to the gas receiving port; rinsing the sample transport line and an interior portion of the nebulizer with the first rinsing liquid; and rinsing an interior portion of the nebulizer with the second rinsing liquid transported through the gas transport line into the interior portion of the nebulizer via the gas receiving port.

摘要翻译： 一种用于提供雾化器冲洗的方法包括通过阀组件将第二冲洗液体和雾化气体引导到雾化器的气体接收端口，阀组件连接到气体输送管线，该气体输送管线被配置成运送至少一个 雾化气体和第二冲洗液体到气体接收口; 用第一冲洗液冲洗样品输送线和喷雾器的内部; 以及用通过气体输送管线输送到喷雾器的内部的第二冲洗液体经由气体接收口冲洗喷雾器的内部。