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公开(公告)号：US07148205B2
公开(公告)日：2006-12-12
申请号：US10600290
申请日：2003-06-20
申请人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
CPC分类号： C12N15/87 , A61K31/70 , A61K47/59 , A61K47/593 , A61K47/645 , A61K48/00 , A61K48/0083 , C07H21/00 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3233 , C12N2320/32 , A61K2300/00
摘要： Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
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公开(公告)号：US07087770B2
公开(公告)日：2006-08-08
申请号：US09779791
申请日：2001-02-08
CPC分类号： A61K48/00 , A61K31/155 , A61K31/198 , A61K38/08 , C07C323/60 , C07C323/62 , C07D207/46 , C07H21/04
摘要： A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
摘要翻译： 含有不稳定二硫键和转导信号的生理条件下的不稳定二硫键化合物。
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公开(公告)号：US06379966B2
公开(公告)日：2002-04-30
申请号：US09450315
申请日：1999-11-29
申请人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
IPC分类号： C12N1585
CPC分类号： A61K48/0041 , A61K48/0008 , A61K48/0083
摘要： Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.
摘要翻译： 公开了用于在细胞中提供核酸表达的复合物。 将多核苷酸和聚合物混合在一起形成复合物，其中络合物的ζ电位不是正的。 然后将复合物递送到其中表达核酸的细胞。
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公开(公告)号：US06867196B1
公开(公告)日：2005-03-15
申请号：US09330909
申请日：1999-06-11
申请人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
CPC分类号： A61K48/0008 , A61K48/0075
摘要： A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.
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公开(公告)号：US06627616B2
公开(公告)日：2003-09-30
申请号：US09447966
申请日：1999-11-23
申请人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
IPC分类号： C12N1500
CPC分类号： C12N15/113 , A61K31/70 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/62 , A61K47/6455 , A61K48/00 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C07H21/00 , C12N15/87 , C12N2320/32 , A61K2300/00
摘要： Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
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公开(公告)号：US07816337B2
公开(公告)日：2010-10-19
申请号：US10780484
申请日：2004-02-17
CPC分类号： C12N15/111 , A61K47/58 , A61K48/00 , A61K48/0041 , C12N15/87 , C12N2310/351 , C12N2320/32
摘要： Described is a process for delivering a biologically active compound to a cell by reversibly linking the compound to a membrane active polymer. In particular, polymer-polynucleotide conjugates are described. Methods for reversibly modifying the polymers to decrease cellular toxicity and improve efficacy are provided.
摘要翻译： 描述了通过可逆地将化合物与膜活性聚合物连接而将生物活性化合物递送至细胞的方法。 特别地，描述了聚合物 - 多核苷酸缀合物。 提供了可逆修饰聚合物以降低细胞毒性并提高功效的方法。
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公开(公告)号：US07442764B2
公开(公告)日：2008-10-28
申请号：US11312319
申请日：2005-12-20
CPC分类号： A61K47/60
摘要： An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described modifiers can also be utilized as cross-linkers.
摘要翻译： 描述了含胺化合物的可逆修饰的方法。 化合物的修饰可用于促进分子在体外和体内递送至细胞，或改变化合物的相互作用或活性。 所描述的改性剂也可以用作交联剂。
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38.发明授权公开(公告)号：US06919091B2
公开(公告)日：2005-07-19
申请号：US10095680
申请日：2002-03-11
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
摘要翻译： 为了向细胞递送核酸，将聚二聚物用于缩合的多核苷酸复合物中。 络合物可以用适量的正电荷和/或负电荷形成，使得所得复合物可以递送到血管外空间并且可以进一步递送至细胞。
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39.发明授权Compositions and methods for drug delivery using amphiphile binding molecules 失效使用两亲性结合分子的药物递送的组合物和方法公开(公告)号：US06740643B2
公开(公告)日：2004-05-25
申请号：US09726792
申请日：2000-11-29
申请人： Jon A. Wolff , James E. Hagstrom , Sean D. Monahan , Vladimir Budker , David B. Rozema , Paul M. Slattum
发明人： Jon A. Wolff , James E. Hagstrom , Sean D. Monahan , Vladimir Budker , David B. Rozema , Paul M. Slattum
IPC分类号： A61K4800
CPC分类号： C12N15/87 , A61K47/6951 , A61K48/00 , A61K48/0025 , B82Y5/00 , C07H21/00
摘要： The present invention relates to the delivery of desired compounds (e.g., nucleic acids) into cells using noncovalent delivery systems which include complexing nucleic acids, amphipathic binding agents, and amphiphiles.
摘要翻译： 本发明涉及使用非共价递送系统将期望的化合物（例如核酸）递送到细胞中，其包括络合的核酸，两亲性结合剂和两亲物。
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公开(公告)号：US06630351B1
公开(公告)日：2003-10-07
申请号：US09589978
申请日：2000-06-07
IPC分类号： C12N1587
CPC分类号： C12N15/87 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
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