4-(4-pyridinyl)-benzamides and their use as rock activity modulators
    31.
    发明授权
    4-(4-pyridinyl)-benzamides and their use as rock activity modulators 有权
    4-(4-吡啶基) - 苯甲酰胺及其作为岩石活性调节剂的用途

    公开(公告)号:US08445686B2

    公开(公告)日:2013-05-21

    申请号:US12675430

    申请日:2008-08-26

    摘要: The present invention relates to novel 4-(4-pyridyl)-benzamides of the formula (I). The compounds I possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of Rho kinases (ROCKs). R1 and R2 are, independently of each other, hydrogen, hydroxy, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-haloalkoxy; R3, R4, R5 and R6 are, independently of each other, hydrogen, hydroxy, halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy, C1-C8-haloalkoxy, amino, C1-C8-alkylamino or di-(C1-C8-alkyl)-amino; R7 is hydrogen, C1-C8-alkyl, C1-C8-haloalkyl, aryl or aryl-C1-C8-alkyl; R8 is a group of the formula —X—W, where X is a single bond, C1-C4-alkylene or C1-C4-alkylene-O—, where the alkylene group in the three last-mentioned radicals may be linear or branched and may be partly or fully halogenated and/or may be substituted by a hydroxyl group and/or may be interrupted by an oxygen atom; and W is a cyclic radical selected from phenyl and a 5- or 6-membered saturated, partly unsaturated or aromatic heterocyclic ring which contains as ring members 1, 2 or 3 heteroatoms selected from O, S and N and optionally 1 or 2 carbonyl groups; R9 is a group of the formula —Y—Z, where Z is hydrogen, halogen, OR11, NR12R13, S(O)m—R14, phenyl which may carry 1, 2, 3 or 4 substituents R15 or a 5- or 6-membered saturated, partly unsaturated or aromatic heterocyclic ring; and Y is linear or branched C1C4-alkylene which may be partly or fully halogenated and/or may be substituted by a hydroxyl group and/or a phenyl ring; or, in case Z is phenyl or the 5- or 6-membered heterocyclic ring as defined above, Y can also be a single bond.

    摘要翻译: 本发明涉及式(I)的新型4-(4-吡啶基) - 苯甲酰胺。 化合物I具有有价值的治疗特性,特别适用于治疗对Rho激酶(ROCK)的调节作用的疾病。 R 1和R 2彼此独立地为氢,羟基,氰基,C 1 -C 8 - 烷基,C 1 -C 8 - 卤代烷基,C 1 -C 8 - 烷氧基或C 1 -C 8 - 卤代烷氧基; R3,R4,R5和R6彼此独立地为氢,羟基,卤素,氰基,C1-C8-烷基,C1-C8-卤代烷基,C1-C8-烷氧基,C1-C8-卤代烷氧基,氨基,C1- C 8 - 烷基氨基或二 - (C 1 -C 8 - 烷基) - 氨基; R 7是氢,C 1 -C 8 - 烷基,C 1 -C 8 - 卤代烷基,芳基或芳基-C 1 -C 8 - 烷基; R8是式-XW的基团,其中X是单键,C1-C4-亚烷基或C1-C4-亚烷基-O-,其中三个最后提及的基团中的亚烷基可以是直链或支链的,并且可以 部分或完全卤化和/或可以被羟基取代和/或可被氧原子中断; 并且W是选自苯基和5-或6-元饱和,部分不饱和或芳族杂环的环状基团,其含有作为环成员1,2或3的选自O,S和N的杂原子以及任选的1或2个羰基 ; R9是式-YZ的基团,其中Z是氢,卤素,OR11,NR12R13,S(O)m -R14,可以带有1,2,3或4个取代基R15或5-或6-元的苯基 饱和,部分不饱和或芳族杂环; Y是可部分或完全卤化和/或可被羟基和/或苯环取代的直链或支链C 1 -C 4亚烷基; 或者Z为苯基或上述5-或6-元杂环的情况下,Y也可以是单键。

    Transmit scaling using multiple queues
    32.
    发明授权
    Transmit scaling using multiple queues 有权
    使用多个队列发送缩放

    公开(公告)号:US08386626B2

    公开(公告)日:2013-02-26

    申请号:US13168403

    申请日:2011-06-24

    IPC分类号: G06F15/16 H04J3/00 G06F3/00

    摘要: According to some embodiments, it may be determined, at a first processing element of a device with a plurality of processing elements, that first data is to be transmitted in association with a first network connection. A first entry associated with the first data may then be stored into a first of a plurality of transmit queues. It may subsequently be determined, at a second processing element of the device, that second data is to be transmitted in association with the first network connection. A second entry associated with the second data may then be stored into a second of the plurality of transmit queues.

    摘要翻译: 根据一些实施例,可以在具有多个处理元件的设备的第一处理元件处确定要与第一网络连接相关联地发送第一数据。 然后可以将与第一数据相关联的第一条目存储在多个发送队列中的第一个中。 随后可以在设备的第二处理元件处确定与第一网络连接相关联地发送第二数据。 然后可以将与第二数据相关联的第二条目存储到多个发送队列中的第二条目中。

    STEERING DATA UNITS TO A CONSUMER
    40.
    发明申请
    STEERING DATA UNITS TO A CONSUMER 有权
    将数据单位转向消费者

    公开(公告)号:US20090089505A1

    公开(公告)日:2009-04-02

    申请号:US11864645

    申请日:2007-09-28

    IPC分类号: G06F12/00

    CPC分类号: G06F12/0806 G06F15/173

    摘要: A computer system may comprise a second device operating as a producer that may steer data units to a first device operating as a consumer. A processing core of the first device may wake-up the second device after generating a first data unit. The second device may generate steering values after retrieving a first data unit directly from the cache of the first device. The second device may populate a flow table with a plurality of entries using the steering values. The second device may receive a packet over a network and store the packet directly into the cache of the first device using a first steering value. The second device may direct an interrupt signal to the processing core of the first device using a second steering value.

    摘要翻译: 计算机系统可以包括作为生产者操作的第二设备,其可以将数据单元引导到作为消费者操作的第一设备。 第一设备的处理核心可以在产生第一数据单元之后唤醒第二设备。 第二设备可以在从第一设备的高速缓存中直接检索第一数据单元之后产生转向值。 第二装置可以使用转向值填充具有多个条目的流表。 第二设备可以通过网络接收分组,并且使用第一转向值将分组直接存储到第一设备的高速缓存中。 第二设备可以使用第二转向值将中断信号引导到第一设备的处理核心。