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61 条记录 (耗时 0.073 秒)

    Method and Device for Measuring System Performance in Real Time
    31.
    发明申请
    Method and Device for Measuring System Performance in Real Time 有权
    实时测量系统性能的方法和设备

    公开(公告)号：US20130179122A1

    公开(公告)日：2013-07-11

    申请号：US13822812

    申请日：2011-07-06

    申请人： Pan Li

    发明人： Pan Li

    IPC分类号： G06F11/30

    CPC分类号： G06F11/3065 ,  G06F11/3409 ,  G06F11/3466 ,  G06F11/3476 ,  G06F11/3495 ,  H04L43/062 ,  H04L43/0829 ,  H04L43/106 ,  H04W24/08 ,  H04W24/10

    摘要： Disclosed are method and device for measuring system performance in real time. The method includes: the foreground receives a real-time measurement task comprising a measurement period parameter constructed by the background according to the concerned service data, with the quantity of the service data being lower than a preset value; the foreground extracts the current data corresponding to the real-time measurement task from a performance measurement cache area according to the measurement period parameter; the foreground acquires the real-time measurement data corresponding to the real-time measurement task according to the current data; and the foreground reports the real-time measurement data to the background. In the present invention, the background sends the concerned service data to the foreground by way of a real-time measurement task, and the foreground merely reports few service data.

    摘要翻译： 公开了实时测量系统性能的方法和装置。 该方法包括：前景接收包括根据相关业务数据由后台构成的测量周期参数的实时测量任务，服务数据量低于预设值; 前景根据测量周期参数从性能测量高速缓存区域提取对应于实时测量任务的当前数据; 前台根据当前数据获取与实时测量任务对应的实时测量数据; 前台将实时测量数据报告给后台。 在本发明中，背景通过实时测量任务将有关业务数据发送到前台，前台仅报告少量业务数据。

    Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase
    32.
    发明授权
    Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase 有权
    c-met蛋白激酶的氨基吡唑三唑并噻二唑抑制剂

    公开(公告)号：US08269012B2

    公开(公告)日：2012-09-18

    申请号：US12788608

    申请日：2010-05-27

    申请人： David Lauffer ,  Pan Li ,  Kira McGinty

    发明人： David Lauffer ,  Pan Li ,  Kira McGinty

    IPC分类号： C07D215/12 ,  A61K31/47

    CPC分类号： C07D513/04

    摘要： The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.

    摘要翻译： 本发明涉及式I化合物，其可用于抑制c-Met蛋白激酶。 本发明还提供包含式I化合物的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。

    Inhibitors of c-Met protein kinase
    33.
    发明授权
    Inhibitors of c-Met protein kinase 有权
    c-Met蛋白激酶抑制剂

    公开(公告)号：US08263776B2

    公开(公告)日：2012-09-11

    申请号：US12788723

    申请日：2010-05-27

    申请人： David Lauffer ,  Pan Li

    发明人： David Lauffer ,  Pan Li

    IPC分类号： C07D215/12 ,  A61K31/47

    CPC分类号： C07D513/04

    摘要： The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.

    摘要翻译： 本发明涉及式I化合物，其可用于抑制c-Met蛋白激酶。 本发明还提供包含式I化合物的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。

    INHIBITORS OF C-MET PROTEIN KINASE
    36.
    发明申请
    INHIBITORS OF C-MET PROTEIN KINASE 有权
    C-MET蛋白激酶抑制剂

    公开(公告)号：US20100305156A1

    公开(公告)日：2010-12-02

    申请号：US12788723

    申请日：2010-05-27

    申请人： David Lauffer ,  Pan Li

    发明人： David Lauffer ,  Pan Li

    IPC分类号： A61K31/4709 ,  C07D513/04 ,  A61P35/00 ,  A61P11/00 ,  A61P9/10 ,  A61P29/00

    CPC分类号： C07D513/04

    摘要： The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.

    摘要翻译： 本发明涉及式I化合物，其可用于抑制c-Met蛋白激酶。 本发明还提供包含式I化合物的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。

    Pyrazole compounds useful as protein kinase inhibitors
    39.
    发明授权
    Pyrazole compounds useful as protein kinase inhibitors 失效
    用作蛋白激酶抑制剂的吡唑化合物

    公开(公告)号：US07473691B2

    公开(公告)日：2009-01-06

    申请号：US09952875

    申请日：2001-09-14

    申请人： Robert Davies ,  Pan Li

    发明人： Robert Davies ,  Pan Li

    IPC分类号： A61K31/496 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  A61K31/541 ,  C07D413/14 ,  C07D417/14

    CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

    摘要： This invention describes novel protein kinase inhibitors of formula VII: wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Ry is T-R3″; T is a valence bond or a C1-4 alkylidene chain; R3″ is an optionally substituted group selected from C1-6 aliphatic, C3-10 carbocyclyl, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; and R1, R2, and R2′ are as described in the specification. The protein kinase are useful for treating diseases such as cancer, diabetes and Alzheimer's disease.

    摘要翻译： 本发明描述了式VII的新型蛋白激酶抑制剂：其中G是环C或环D; 环C选自苯基，吡啶基，嘧啶基，哒嗪基，吡嗪基或1,2,4-三嗪基，其中所述环C具有一个或两个独立地选自-R 1的邻位取代基; 环D是选自芳基，杂芳基，杂环基或碳环基的5-7元单环或8-10元双环; Ry是T-R3“; T是价键或C 1-4亚烷基链; R3“是选自C1-6脂族，C3-10碳环基，C6-10芳基，具有5-10个环原子的杂芳基环或具有5-10个环原子的杂环基的任选取代的基团; 并且R1，R2和R2'如说明书中所述。 蛋白激酶可用于治疗疾病如癌症，糖尿病和阿尔茨海默氏病。