公开(公告)号：US10786353B2

公开(公告)日：2020-09-29

申请号：US15901782

申请日：2018-02-21

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.

公开(公告)号：US20200085573A1

公开(公告)日：2020-03-19

申请号：US16691244

申请日：2019-11-21

Applicant: Edwards Lifesciences Corporation

Inventor： Dustin P. Armer ,  Sean Chow ,  Jenny Nguyen ,  Emil Karapetian ,  Tri D. Tran

IPC: A61F2/24

Abstract: Anchor devices and methods used to secure a prosthetic valve to a native valve annulus are described. The anchor device can be a separate expandable element from the prosthetic valve that is first advanced to the annulus and deployed, after which an expandable prosthetic valve is advanced to within the annulus and deployed. The combination of the two elements can apply a clamping force to the valve leaflets which holds the prosthetic valve in place. The anchor device can have a lower or ventricular portion and an upper or atrial portion. The anchor device can include one or more leaflet clamping portions. One, two, or more upstanding vertical posts between the clamping portions can extend upward at the valve commissures and support the upper portion, which can include one or more structures for leak prevention.

公开(公告)号：US20190209322A1

公开(公告)日：2019-07-11

申请号：US16358480

申请日：2019-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2250/0014

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US20190009061A1

公开(公告)日：2019-01-10

申请号：US16128294

申请日：2018-09-11

Applicant: Edwards Lifesciences Corporation

Inventor： Tri D. Tran ,  Sean Chow ,  Ronaldo C. Cayabyab

IPC: A61M25/01 ,  A61M25/00 ,  A61F2/24

Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion, a distal portion, and a pull-wire lumen that extends at least partially through the proximal and distal portions. A pull wire extends through the pull-wire lumen and has a proximal end portion and a distal end portion, wherein the distal end portion of pull wire is fixed to the distal end portion of the shaft. An adjustment mechanism is operatively connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the distal portion of the shaft. An axially non-compressible pull-wire sleeve extends co-axially through the pull-wire lumen and over the pull wire.

公开(公告)号：US20250144374A1

公开(公告)日：2025-05-08

申请号：US19015139

申请日：2025-01-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Sean Chow ,  Jeong Soo Lee ,  Kevin Jiang

IPC: A61M25/06 ,  A61M25/00

Abstract: Disclosed is an introducer for a medical device wherein the introducer is configured to be substantially sterilized throughout entire d1 and d2 along substantially entire I1 and the introducer includes a first and a second polymer layer that are coextruded.

公开(公告)号：US12121676B2

公开(公告)日：2024-10-22

申请号：US17026644

申请日：2020-09-21

Applicant: Edwards Lifesciences Corporation

Inventor： Tri D. Tran ,  Sean Chow ,  Ronaldo C. Cayabyab

IPC: A61M25/01 ,  A61F2/24 ,  A61M25/00

CPC classification number: A61M25/0147 ,  A61F2/2436 ,  A61M25/0071 ,  A61M25/0136 ,  A61F2/2427 ,  A61M2025/0161

Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion and a distal portion, and first and second pull wires having respective proximal portions and respective distal portions. The proximal portions of the first and second pull wires extend through the proximal portion of the shaft in close proximity to each other. The distal portions of the first and second pull wires extend through the distal portion of the shaft in close proximity to each other over a first distance defining a primary flexing section, diverge away from each other over a second distance, and then extend parallel to each other at angularly spaced locations over a third distance defining a secondary flexing section.

公开(公告)号：US20240216139A1

公开(公告)日：2024-07-04

申请号：US18607271

申请日：2024-03-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nicholas Brandon Aders ,  Kristen Hicks ,  Gil Senesh ,  Michael R. Bialas ,  Tung T. Le ,  Sean Chow ,  Thanh Huy Le

IPC: A61F2/24 ,  B23P11/00 ,  A61F2/95

CPC classification number: A61F2/2433 ,  B23P11/005 ,  A61F2/9524 ,  A61F2240/001 ,  A61F2250/0039

Abstract: Devices and methods for crimping a prosthetic heart valve onto a delivery device are described. In some embodiments, valves are crimped over an inflatable balloon and between proximal and distal shoulders mounted on a shaft inside the balloon. Crimping methods can include multiple compression steps with the valve located in different axial positions relative to the crimping jaws at each different step. In some methods, the valve may extend partially outside of the crimping jaws during certain crimping steps, such that the crimping force is only applied to the part of the valve that is inside the jaws. Exemplary crimping devices can include two or more adjacent sets of jaws that close down to different inner diameters, such that different parts of a valve get compressed to different outer diameters at the same time during a single crimping step.

公开(公告)号：US11864997B2

公开(公告)日：2024-01-09

申请号：US17111148

申请日：2020-12-03

Applicant: Edwards Lifesciences Corporation

Inventor： Tri D. Tran ,  Ronaldo C. Cayabyab ,  David J. Evans ,  Sean Chow ,  Christopher Chia ,  Tamir S. Levi

IPC: A61F2/24 ,  A61F2/958 ,  A61M25/10 ,  A61F2/95 ,  A61F2/48

CPC classification number: A61F2/2433 ,  A61F2/958 ,  A61F2/484 ,  A61F2/9517 ,  A61F2002/9586 ,  A61F2250/0003 ,  A61F2250/0021 ,  A61M25/1002 ,  A61M25/10184 ,  A61M2025/1013 ,  A61M2025/1084

Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.

公开(公告)号：US20230077068A1

公开(公告)日：2023-03-09

申请号：US17932654

申请日：2022-09-15

Applicant: Edwards Lifesciences Corporation

Inventor： Ilan Tamir ,  David Maimon ,  Hanoch Cohen-Tzemach ,  Adva Alon ,  Amir Keret ,  Eyal Leiba ,  Boaz Manash ,  Sean Chow ,  Ziv Yohanan ,  Shay Zarneger

IPC: A61F2/24 ,  A61B17/3205 ,  A61B18/14 ,  A61B17/32 ,  A61B17/34

Abstract: Methods and tools for implanting prosthetic heart valves and modifying leaflets of an existing valvular structure in a subject are disclosed herein. Prior to or during implantation of the prosthetic heart valve within the existing valvular structure, each tool can be provided in the ascending aorta (or equivalent thereof) of a subject and can be used to pierce, lacerate, slice, tear, cut or otherwise modify a leaflet or commissure of the existing valvular structure. The existing valvular structure can be a native aortic valve or other native heart valve, or a previously-implanted prosthetic heart valve. The modification can avoid, or at least reduce the likelihood of, issues that leaflets of the existing valvular structure might otherwise cause once the prosthetic heart valve has been fully installed, for example, obstruction of blood flow to the coronary arteries and/or improper valve mounting due to a non-circular cross-section.

公开(公告)号：US20220211498A1

公开(公告)日：2022-07-07

申请号：US17706253

申请日：2022-03-28

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.