公开(公告)号：US09149478B2

公开(公告)日：2015-10-06

申请号：US13166892

申请日：2011-06-23

申请人： Thomas Klein ,  Michael Mark ,  Leo Thomas

发明人： Thomas Klein ,  Michael Mark ,  Leo Thomas

IPC分类号： A61K38/28 ,  A61K31/522 ,  A61K31/155 ,  A61K45/06

CPC分类号： A61K31/522 ,  A61K31/155 ,  A61K38/28 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.

摘要翻译： 本发明涉及治疗和/或预防代谢疾病的方法，其包括联合施用DPP-4抑制剂和长效胰岛素。 本发明还涉及用于皮下或透皮使用的DPP-4抑制剂。

公开(公告)号：US08788214B2

公开(公告)日：2014-07-22

申请号：US12934578

申请日：2010-02-08

申请人： Thomas Klein ,  Joachim Dudenhausen

发明人： Thomas Klein ,  Joachim Dudenhausen

IPC分类号： G01N33/48 ,  G06F19/00 ,  G06Q50/22

CPC分类号： G06F19/322 ,  G06F19/00 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H50/70 ,  Y02A90/22 ,  Y02A90/26

摘要： The invention relates to a system for the automatic, rapid and dynamic allocation of biological cells for transplantation, therapy, or research purposes between collection centers or banks (storage sites) and hospitals, transplant centers or research facilities, and for monitoring and supporting the processes from request transmission up to delivery of a cell preparation suitable for allogeneic transplantation, via the use of allocated preparations up to tracking the results in the patient and providing these data for statistical and other purposes, as well as assigning molecular-diagnostic results of individuals with the aim of verifying options—even in advance—of transplantations among the inventory of registers or banks. Using said system, it is possible for the first time—even in advance and online and with automatic retries—to propose complete solutions in the form of transplantations in specific and individual cases.

摘要翻译： 本发明涉及一种用于在收集中心或银行（存储场所）和医院，移植中心或研究设施之间自动，快速和动态地分配用于移植，治疗或研究目的的生物细胞的系统，以及用于监测和支持过程 从请求传输到适用于同种异体移植的细胞制剂的传递，通过使用分配的准备物质来跟踪患者的结果并提供这些数据用于统计学和其他目的，以及将个体的分子诊断结果 即使在提前登记册或银行清单中的移植过程中验证选项的目的也是如此。 使用所述系统，可以在第一次甚至提前和在线并且自动重试 - 以特定和个别情况下以移植的形式提出完整的解决方案。

公开(公告)号：US08596722B2

公开(公告)日：2013-12-03

申请号：US13076942

申请日：2011-03-31

申请人： Thomas Haubrich ,  Thomas Klein

发明人： Thomas Haubrich ,  Thomas Klein

IPC分类号： B60N2/46

CPC分类号： B60N2/773 ,  B60N2/777 ,  B60N2/797

摘要： The present invention relates to a machine operator seat of a construction machine having a seat surface, a backrest, which is situated opposite to the front seat edge in the longitudinal direction of the seat surface, and at least one armrest situated laterally to the seat surface, comprising a base part, an arm support, and at least one operating element, the arm support being situated in the rear area in the longitudinal direction and the at least one operating element being situated in the front area of the armrest in the longitudinal direction. Furthermore, the present invention relates to a construction machine, in particular a road miller, recycler, stabilizer, or a road roller, in particular a tandem roller, having such a machine operator seat.

摘要翻译： 本发明涉及一种施工机械的机器操作者座椅，其具有座位表面，靠背，其位于座椅表面的纵向方向上与前座椅边缘相对的位置，以及至少一个位于座位表面侧面的扶手 ，其包括基部，臂支撑件和至少一个操作元件，所述臂支撑件沿纵向方向位于后区域中，并且所述至少一个操作元件位于所述扶手的前部区域中的纵向方向 。 此外，本发明涉及一种具有这种机器操作员座椅的建筑机械，特别是道路铣刀，回收机，稳定器或具有串联辊的压路机。

公开(公告)号：US20130134997A1

公开(公告)日：2013-05-30

申请号：US13354508

申请日：2012-01-20

申请人： Wolfgang Pfeiffer ,  Thomas Klein

发明人： Wolfgang Pfeiffer ,  Thomas Klein

IPC分类号： G01R27/08

CPC分类号： G01R27/08 ,  G01M13/00 ,  G01N1/00 ,  H01L21/00 ,  H01L2221/00

摘要： A method for detecting an imperfect mounting of an essentially rod-shaped metallic object in a metallic hollow shaft is provided. The imperfect mounting may lead to the formation of metallic particles. The rod-shaped object is mounted electrically insulated from the hollow shaft. The electrical resistance between the rod-shaped object and the hollow shaft is measured. An alert is issued when the electrical resistance is lower than a predefined level. A device includes a spin unit with a hollow drive shaft and a nozzle mounted inside the hollow shaft. The device is configured to use the inventive method.

摘要翻译： 提供一种用于检测基本上棒状的金属物体在金属空心轴中的不完美安装的方法。 不完美的安装可能导致金属颗粒的形成。 杆形物体与空心轴电绝缘地安装。 测量棒状物体与空心轴之间的电阻。 当电阻低于预定义电平时发出警报。 一种装置包括具有中空驱动轴的旋转单元和安装在中空轴内的喷嘴。 该设备被配置为使用本发明的方法。

公开(公告)号：US20130132379A1

公开(公告)日：2013-05-23

申请号：US13699147

申请日：2011-05-20

申请人： Thomas Klein

发明人： Thomas Klein

IPC分类号： G06F19/00

CPC分类号： G06F19/32 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00 ,  G16H10/60

摘要： The invention describes a method for the identification and selection for at least one cord blood unit for a transplantation.

摘要翻译： 本发明描述了用于识别和选择用于移植的至少一个脐带血单元的方法。

公开(公告)号：US20130041680A1

公开(公告)日：2013-02-14

申请号：US13576886

申请日：2011-02-07

申请人： Thomas Klein

发明人： Thomas Klein

IPC分类号： G06Q50/22

CPC分类号： G06Q10/00 ,  G06Q50/22

摘要： The invention relates to a system for the automatic, fast and dynamic mediation of biological cells for transplantation, therapy or research purposes for registers of patients having differing indications between extraction centers or banks (deposits) and clinics, transplantation centers or research institutions, service providers (diagnosis, further processing of the preparations and logistics) and the monitoring and support of the processes of requirements transmission, integration from diagnostics technologies and techniques, to further processing, to delivery and payment of a cell preparation suited for allogeneic transplantation or other biological preparation, to the use of the mediated preparation to tracking of the results in patients and to the provision of said data for statistical and other purposes. The system according to the invention is for the first time able to suggest, online and automatically, complete solution proposals for specific stored transplantations for individual patients in extensive registers of patients and to consider prioritized deposits and to create medicinally and logistically advantageous solution proposals when ordering a plurality of preparations. The system is furthermore for the first time able to automatically integrate and coordinate service providers incorporated in the process, such as logistics companies and further processors of the required preparations, into to the process and can conduct all processes and financial transactions as a central tool (platform).

摘要翻译： 本发明涉及一种用于移植，治疗或研究目的的生物细胞的自动，快速和动态调停的系统，用于在提取中心或银行（存款）和诊所，移植中心或研究机构，服务提供者之间具有不同适应症的患者的登记 （诊断，进一步处理准备和物流）以及监测和支持要求传输过程，诊断技术和技术的整合，进一步处理，交付和支付适合同种异体移植或其他生物制剂的细胞制剂 使用介导的准备来跟踪患者的结果，以及为统计学和其他目的提供所述数据。 根据本发明的系统首次能够在广泛的患者登记册中针对特定存储的移植的建议，在线和自动地提出完整的解决方案提案，并考虑优先存款，并在订购时创建医学上和后勤性的解决方案提案 多种制剂。 此外，该系统首次能够自动整合和协调过程中纳入的服务提供商（如物流公司和进一步处理所需准备工作），并将其作为中心工具进行所有流程和金融交易（ 平台）。

公开(公告)号：US20120123792A1

公开(公告)日：2012-05-17

申请号：US13147835

申请日：2010-02-08

申请人： Thomas Klein

发明人： Thomas Klein

IPC分类号： G06Q50/22

CPC分类号： G06F19/3418 ,  G06F19/00 ,  G06Q50/22 ,  G16H10/60 ,  G16H50/70

摘要： The invention relates to a system for automatically, rapidly, and dynamically funding biological cells for transplantion, treatment, or research purposes between collection centers or banks (storage places) and hospitals, transplant centers, or research facilities, monitoring and assisting with processes from the transmission of requests, the delivery of cell preparation suitable for allogeneic transplantation, and the use of the found preparations to the monitoring of the result in the patient, and making said data available for statistical and other purposes, wherein samples are taken before and after the transplantation to analyze genomes, proteomes, transcriptomes, epigenomes, and/or metbolomes.

摘要翻译： 本发明涉及一种用于在收集中心或银行（储存场所）和医院，移植中心或研究设施之间自动，快速和动态地为生物细胞提供移植，治疗或研究目的的系统，监测和协助来自 请求的传送，适用于同种异体移植的细胞制备的递送，以及使用所发现的制剂来监测患者的结果，并使所述数据可用于统计学和其他目的，其中样品在前后 移植来分析基因组，蛋白质组，转录组，表观基因组和/或metbolomes。

公开(公告)号：US07784804B2

公开(公告)日：2010-08-31

申请号：US11920586

申请日：2006-03-27

申请人： Eduard Span ,  Markus Beiss ,  Thomas Klein

发明人： Eduard Span ,  Markus Beiss ,  Thomas Klein

IPC分类号： B62D3/12

CPC分类号： B62D3/12 ,  Y10T74/1967

摘要： A steering gear for a rack and pinion steering system, including a housing in which a steering rack is guided for displacement along its axis, has an auxiliary support which is located at an axial end of the housing, the auxiliary support limiting a bending of the steering rack.

摘要翻译： 一种用于齿条和小齿轮转向系统的转向齿轮，包括其中转向齿条被引导以沿其轴线移位的壳体，具有位于壳体的轴向端部处的辅助支撑件，辅助支撑件限制了弯曲 转向架。

公开(公告)号：US07780225B2

公开(公告)日：2010-08-24

申请号：US12037645

申请日：2008-02-26

申请人： Thomas Klein ,  Thomas Haubrich

发明人： Thomas Klein ,  Thomas Haubrich

IPC分类号： B60N2/38 ,  B60N2/06

CPC分类号： B62D33/0625 ,  B60N2/005 ,  B60N2/062 ,  E01C19/26 ,  E01C2301/30

摘要： A seating apparatus is described for arrangement in a driver's cabin of a construction vehicle, especially a soil compacting machine, comprising a treading surface and an operating desk. The seating apparatus comprises a driver's seat and an adjusting device, and the adjusting device comprises two guide rails and a seat carrier. The seat carrier is held on the guide rails and is adjustable transversally to the traveling direction of the construction vehicle. The guide rails are arranged next to the treading surface used by the driver in such a way that the seat carrier can be displaced relative to the treading surface in a freely floating manner over the same.

摘要翻译： 描述了一种安装在建筑车辆的驾驶室中的座椅装置，特别是包括踩踏面和操作台的土压实机。 座椅装置包括驾驶员座椅和调节装置，调节装置包括两个导轨和座椅支架。 座椅支架被保持在导轨上，并且可以横向调整到施工车辆的行进方向。 导轨被布置在驾驶员使用的行走面旁边，使座椅支架相对于踏面可以以自由浮动的方式在其上移动。

公开(公告)号：US20090093391A1

公开(公告)日：2009-04-09

申请号：US12234148

申请日：2008-09-19

申请人： Thomas Klein ,  Wolfgang Wambach ,  Ralf-Johann Moritz

发明人： Thomas Klein ,  Wolfgang Wambach ,  Ralf-Johann Moritz

IPC分类号： C11D7/42

CPC分类号： C11D3/33 ,  C11D3/386 ,  C11D7/3245 ,  C11D7/40

摘要： The present invention relates to substance mixtures comprising at least one complexing agent and at least one enzyme, and to the use thereof in liquid washing compositions and liquid cleaning compositions, said complexing agent having a complex formation constant for calcium of from 3 to 6 and said calcium-binding enzyme having a calcium binding capacity of at least 1 molar equivalent of calcium per molar equivalent of enzyme.

摘要翻译： 本发明涉及包含至少一种络合剂和至少一种酶的物质混合物，以及其在液体洗涤组合物和液体清洗组合物中的用途，所述络合剂具有3至6的钙的络合物形成常数，并且所述 钙结合酶，其钙结合能力为每摩尔当量酶至少1摩尔当量的钙。