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公开(公告)号：US07820190B2
公开(公告)日：2010-10-26
申请号：US10751289
申请日：2004-01-02
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings, particularly primer coatings, for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. The primer coatings include diacrylates and polyacrylates.
摘要翻译： 提供了用于可植入装置或腔内假体（例如支架）的涂层，特别是底漆涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。 底漆涂料包括二丙烯酸酯和聚丙烯酸酯。
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公开(公告)号：US20100168843A1
公开(公告)日：2010-07-01
申请号：US12723552
申请日：2010-03-12
申请人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/82
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US20080262519A1
公开(公告)日：2008-10-23
申请号：US11962077
申请日：2007-12-20
申请人： Geoffrey C. GURTNER , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon M. Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. GURTNER , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon M. Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/11
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微手术技术的小腔
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公开(公告)号：US20060280770A1
公开(公告)日：2006-12-14
申请号：US11506656
申请日：2006-08-17
申请人： Syed Hossainy , Stephen Pacetti , Keith Fong , Vinayak Bhat , Deborra Sanders Millare , Judy Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed Hossainy , Stephen Pacetti , Keith Fong , Vinayak Bhat , Deborra Sanders Millare , Judy Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61K9/22
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US20060134070A1
公开(公告)日：2006-06-22
申请号：US11016017
申请日：2004-12-17
申请人： Evgenia Mandrusov , Charles Claude , Eugene Michal
发明人： Evgenia Mandrusov , Charles Claude , Eugene Michal
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译： 一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。 一种方法，包括鉴定心肌组织内的梗塞区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入到梗死区域。 一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的单独量的多个微粒。
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公开(公告)号：US06740040B1
公开(公告)日：2004-05-25
申请号：US09774334
申请日：2001-01-30
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B2017/00247 , A61B2018/00392
摘要： A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
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37.发明授权Primer layer coatings of a material with a high content of hydrogen bonding groups for implantable devices and a method of forming the same 有权用于可植入装置的具有高含量氢键基团的材料的底漆层涂层及其形成方法公开(公告)号：US08652501B2
公开(公告)日：2014-02-18
申请号：US13427608
申请日：2012-03-22
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Primer coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The primer coatings can include a material with a high content of hydrogen bonding groups, such as some types of epoxy polymers and melamine formaldehydes. Coatings subsequently disposed over the primer coating can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的底漆涂层，包括形成涂层的方法。 底漆涂层可以包括具有高含量氢键基团的材料，例如一些类型的环氧聚合物和三聚氰胺甲醛。 随后布置在底漆涂层上的涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US08608760B2
公开(公告)日：2013-12-17
申请号：US11962077
申请日：2007-12-20
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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公开(公告)号：US08337874B2
公开(公告)日：2012-12-25
申请号：US12723534
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US20120185034A1
公开(公告)日：2012-07-19
申请号：US13427608
申请日：2012-03-22
申请人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/82
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can serve as a primer coating for subsequent coatings that can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可以用作后续涂层的底漆涂层，其可用于递送活性成分或活性成分的组合。
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