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公开(公告)号：US20060265043A1
公开(公告)日：2006-11-23
申请号：US11388355
申请日：2006-03-24
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译： 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。
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公开(公告)号：US20060134070A1
公开(公告)日：2006-06-22
申请号：US11016017
申请日：2004-12-17
申请人： Evgenia Mandrusov , Charles Claude , Eugene Michal
发明人： Evgenia Mandrusov , Charles Claude , Eugene Michal
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译： 一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。 一种方法，包括鉴定心肌组织内的梗塞区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入到梗死区域。 一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的单独量的多个微粒。
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3.发明授权公开(公告)号：US06702744B2
公开(公告)日：2004-03-09
申请号：US10011071
申请日：2001-11-30
申请人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
发明人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
IPC分类号： A61B812
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
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4.发明授权Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery 有权刺激治疗性血管生成的药物，以及能够进行递送的技术和装置公开(公告)号：US08521259B2
公开(公告)日：2013-08-27
申请号：US10781984
申请日：2004-02-18
申请人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
发明人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
IPC分类号： A61B5/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
摘要翻译： 一种包括将导管定位在血管中的位置的方法; 在该位置成像血管壁的一部分的厚度; 识别治疗部位; 将针距离进入血管壁至治疗部位; 并将治疗剂通过针引入治疗部位。 一种组合物，其包含炎症诱导剂和具有适于经血管递送的粒度的微球形式的载体。 一种包含载体中的治疗性血管生成促进剂和与载体偶联的调理蛋白抑制剂的组合物。 用于递送治疗性血管生成促进剂的装置。
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公开(公告)号：US20110070307A1
公开(公告)日：2011-03-24
申请号：US12955101
申请日：2010-11-29
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译： 一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。 一种方法，包括鉴定心肌组织内的梗死区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入梗塞区域。 一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的单独量的多个微粒。
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公开(公告)号：US07854944B2
公开(公告)日：2010-12-21
申请号：US11016017
申请日：2004-12-17
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译： 一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。 一种方法，包括鉴定心肌组织内的梗死区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入梗塞区域。 一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的单独量的多个微粒。
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公开(公告)号：US20050266038A1
公开(公告)日：2005-12-01
申请号：US10857141
申请日：2004-05-27
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L1/00 , C08L33/14 , C08L2666/26
摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。
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8.发明申请Implantable medical devices incorporating plasma polymerized film layers and charged amino acids 有权包含等离子体聚合膜层和带电氨基酸的可植入医疗器械公开(公告)号：US20050249777A1
公开(公告)日：2005-11-10
申请号：US11183030
申请日：2005-07-15
申请人： Eugene Michal , Charles Claude
发明人： Eugene Michal , Charles Claude
CPC分类号： A61F2/86 , A61F2250/0067 , A61L31/047 , A61L31/084 , A61L31/16 , A61L2300/114 , A61L2300/25 , B05D1/62 , B05D2350/60
摘要： An implantable medical device, such as a stent, is disclosed comprising an amino acid or a polypeptide bonded to a plasma polymerized film layer formed on the device. A method of manufacturing the same is also disclosed.
摘要翻译： 公开了一种植入式医疗装置，例如支架，其包括与形成在该装置上的等离子体聚合膜层结合的氨基酸或多肽。 还公开了一种制造该方法的方法。
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9.发明申请公开(公告)号：US20050031874A1
公开(公告)日：2005-02-10
申请号：US10944319
申请日：2004-09-17
CPC分类号： C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
摘要： A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.
摘要翻译： 一种医疗装置，其包括具有结合到所述基底的至少一部分的等离子体聚合功能的基底。 通过与等离子体聚合官能团的结合，具有与等离子体聚合官能团互补的官能团的超氧化物歧化酶模拟剂与基板的该部分结合。
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公开(公告)号：US09561309B2
公开(公告)日：2017-02-07
申请号：US10857141
申请日：2004-05-27
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L1/00 , C08L33/14 , C08L2666/26
摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。
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