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公开(公告)号：US20090062296A1
公开(公告)日：2009-03-05
申请号：US11478129
申请日：2006-06-28
申请人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
发明人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
IPC分类号： A61K31/495 , C07C233/01 , A61K31/164 , C07C69/52 , A61K31/445 , A61P27/02 , A61P9/12 , C07D211/06 , A61K31/215 , C07D241/04
CPC分类号： C07C405/00 , C07D207/08 , C07D295/12 , C07D295/13
摘要： Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素酰胺的硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20090030076A1
公开(公告)日：2009-01-29
申请号：US12210975
申请日：2008-09-15
IPC分类号： A61K31/215 , C07C69/22 , A61P27/02
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20080090857A1
公开(公告)日：2008-04-17
申请号：US11905893
申请日：2007-10-05
IPC分类号： A61K31/505 , A61P29/00 , A61P7/00 , A61P9/00 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US07297808B2
公开(公告)日：2007-11-20
申请号：US11590770
申请日：2006-11-01
IPC分类号： C07C205/00 , C07C331/00 , C07C203/00 , C07C381/00 , A01N37/00 , A61K31/21
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US20070072942A1
公开(公告)日：2007-03-29
申请号：US11590770
申请日：2006-11-01
申请人： Francesca Benedini , Ennio Ongini , Piero Soldato
发明人： Francesca Benedini , Ennio Ongini , Piero Soldato
IPC分类号： A61K31/21 , C07C203/00
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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公开(公告)号：US07166638B2
公开(公告)日：2007-01-23
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/40 , A61K31/401 , C07D209/10 , C07D207/325
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US20050165084A1
公开(公告)日：2005-07-28
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/21 , A61K31/40 , A61K31/404 , A61K31/405 , A61P3/06 , C07D207/34 , C07D209/10 , C07D209/24 , C07D209/26 , C07D213/55 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可以用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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38.发明申请COMPOSITIONS COMPRISING ATORVASTATIN 4-(NITROOXY) BUTYL ESTER AND A HYPOLIPIDEMIC DRUG 审中-公开包含4-（硝基）丁酯的ATORVASTATIN和高血压药物的组合物公开(公告)号：US20110077232A1
公开(公告)日：2011-03-31
申请号：US12995953
申请日：2009-05-18
申请人： Angela Monopoli , Stefano Biondi , Ennio Ongini
发明人： Angela Monopoli , Stefano Biondi , Ennio Ongini
IPC分类号： A61K31/397 , A61K31/40 , A61P3/10 , A61P25/28 , A61P25/16 , A61P7/00 , A61P25/00 , A61P37/00
CPC分类号： A61K45/06 , A61K31/40 , A61K2300/00
摘要： The present invention relates to compositions comprising atorvastatin 4-(nitrooxy) butyl ester and a hypolipidemic, in particular ezetimibe and fenofibrate. The invention discloses also their use as cholesterol-reducing drugs, as drugs having immunosuppressive properties, antioxidant, antithrombotic and anti-inflammatory activity, effects on endothelial function, and for treating and/or preventing acute coronary syndromes, stroke, atherosclerosis, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.
摘要翻译： 本发明涉及包含阿托伐他汀4-（硝基氧基）丁酯和降血脂药物，特别是依泽替米贝和非诺贝特的组合物。 本发明还公开了它们作为具有免疫抑制性，抗氧化作用，抗血栓形成和抗炎活性，对内皮功能的作用以及用于治疗和/或预防急性冠状动脉综合征，中风，动脉粥样硬化，神经退行性疾病， 如阿尔茨海默氏症和帕金森病以及自身免疫性疾病，如多发性硬化。
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公开(公告)号：US08367711B2
公开(公告)日：2013-02-05
申请号：US13483213
申请日：2012-05-30
申请人： Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
发明人： Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
IPC分类号： A61K31/41 , A61K31/405 , C07D209/00 , C07D257/04
CPC分类号： C07D403/10 , C07D235/20 , C07D257/04 , C07D409/06 , C07D493/04
摘要： A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)—O— and P(O)(OR6)—O—; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
摘要翻译： 具有其中R为例如Y的结构的化合物选自1）R5，2）-C（R1R2）（C（R3R4））0-1Y1R5和3）-C（R1R2） - O-Y1R5; R 1，R 2，R 3和R 4独立地选自氢和C 1-4烷基; R5是 Y1选自C（O）-O-和P（O）（OR 6）-O-; R6为氢或CH3，或其药学上可接受的盐，以及使用该化合物治疗高血压的方法。
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公开(公告)号：US08252825B2
公开(公告)日：2012-08-28
申请号：US12743402
申请日：2008-11-21
申请人： Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Nicoletta Almirante , Silvia Stefanini , Laura Storoni , Stefano Biondi , Ennio Ongini
发明人： Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Nicoletta Almirante , Silvia Stefanini , Laura Storoni , Stefano Biondi , Ennio Ongini
IPC分类号： A61K31/4184 , A61K31/4178 , C07D403/10 , A61P9/12
CPC分类号： C07D403/10
摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is 1) —(CH2)3R5, 2) —C(O)(CH2)2R5, 3) —C(R1R2)OC(O)O(CH2)nR5, wherein n is 1 or 2, 4) —C(R1R2)OC(O)CH2CH2R5, 5) —C(R1R2)OC(O)OCH2CH2C(R3R4)R5, provided that when Y is —C(O)(CH2)2R5, then R is R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is —CH(ONO2)CH(ONO2)R6; R6 is selected from CH3, CH2CH3 and CH(CH3)2; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y是1） - （CH 2）3 R 5，2）-C（O）（CH 2）2 R 5，3）-C（R 1 R 2）OC（O）O （CH 2）n R 5，其中n为1或2，4）-C（R 1 R 2）OC（O）CH 2 CH 2 R 5，5）-C（R 1 R 2）OC（O）OCH 2 CH 2 C（R 3 R 4） O）（CH 2）2 R 5，则R 1是R 1，R 2，R 3和R 4独立地选自氢和C 1-4烷基; R5是-CH（ONO2）CH（ONO2）R6; R 6选自CH 3，CH 2 CH 3和CH（CH 3）2; 或其药学上可接受的盐或水合物，其可用于治疗高血压。
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