公开(公告)号：US08360990B2

公开(公告)日：2013-01-29

申请号：US11981024

申请日：2007-10-31

申请人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

发明人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

IPC分类号： A61B10/00

CPC分类号： A61B10/0233 ,  A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/32053 ,  A61B17/3417 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/00473 ,  A61B2017/3405

摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.

公开(公告)号：US08343071B2

公开(公告)日：2013-01-01

申请号：US11981149

申请日：2007-10-31

申请人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

发明人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

IPC分类号： A61B10/00

CPC分类号： A61B10/0233 ,  A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/32053 ,  A61B17/3417 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/00473 ,  A61B2017/3405

摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.

摘要翻译： 本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。 该装置包括可释放地固定到驱动器部件的探针部件。 探针部件具有细长的管状部分，穿透远侧末端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割组织样本 通过对组织切割构件的内腔施加真空而通过孔被吸入装置的内部。 驱动器具有用于操作探头部件的元件的驱动部件。 组织穿透的远侧末端优选地具有三凹曲面形状，其具有三个弯曲的切割边缘，其导致尖锐的远端点。

公开(公告)号：US20100268117A1

公开(公告)日：2010-10-21

申请号：US12794480

申请日：2010-06-04

申请人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

发明人： Martin V. Shabaz ,  Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

IPC分类号： A61B10/02

CPC分类号： A61B10/0233 ,  A61B10/02 ,  A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/3417 ,  A61B90/30 ,  A61B90/39 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/0046 ,  A61B2017/00473 ,  A61B2017/3405 ,  A61B2017/3454 ,  A61B2090/0811 ,  A61B2090/309 ,  B23Q17/2404 ,  F21V33/0068

摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component with an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component to which the probe component is releasably secured. The driver has a drive member for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section.

摘要翻译： 本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。 该装置包括具有细长管状部分的探针部件，穿透远侧末端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割 组织样本通过向组织切割构件的内腔施加真空而通过孔被拉入装置的内部。 该装置还具有驱动器部件，探针组件可释放地固定到该部件上。 驱动器具有用于调节管状部分的方向并因此调节其中的孔的驱动构件和一个或多个驱动构件，用于移动管状区段内的组织切割构件以将组织样本从延伸到管状部分内部的组织切断 通过光圈。 赋予组织切割器的运动至少是纵向的，并且优选也是振动和/或旋转以有效地将组织样本与延伸穿过管状部分中的孔的组织分离。

公开(公告)号：US08636637B2

公开(公告)日：2014-01-28

申请号：US13571495

申请日：2012-08-10

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US08251884B2

公开(公告)日：2012-08-28

申请号：US12151153

申请日：2008-05-02

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

公开(公告)号：US20080139928A1

公开(公告)日：2008-06-12

申请号：US11985997

申请日：2007-11-19

申请人： Paul Lubock ,  Michael L. Jones ,  Ethan Broadaway ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Ethan Broadaway ,  Frank R. Louw

IPC分类号： A61B5/055 ,  A61B10/02

CPC分类号： A61B17/32 ,  A61B17/3417 ,  A61B17/3431 ,  A61B17/3468 ,  A61B17/3496 ,  A61B17/3498 ,  A61B90/39 ,  A61B2017/00477 ,  A61B2017/00911 ,  A61B2090/062 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3987

摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.

公开(公告)号：US09180312B2

公开(公告)日：2015-11-10

申请号：US13302086

申请日：2011-11-22

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US08079946B2

公开(公告)日：2011-12-20

申请号：US11593784

申请日：2006-11-06

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US20090124845A1

公开(公告)日：2009-05-14

申请号：US12290050

申请日：2008-10-27

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US20080139925A1

公开(公告)日：2008-06-12

申请号：US11985989

申请日：2007-11-19

申请人： Paul Lubock ,  Michael L. Jones ,  Ethan Broadaway ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Ethan Broadaway ,  Frank R. Louw

IPC分类号： A61B5/055

CPC分类号： G01R33/286 ,  A61B5/055 ,  A61B90/39 ,  A61B2090/3954 ,  A61B2090/3987

摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.

摘要翻译： 具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。 优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。