公开(公告)号：US4939085A

公开(公告)日：1990-07-03

申请号：US107673

申请日：1987-10-09

申请人： Fuminori Arai

发明人： Fuminori Arai

IPC分类号： C12Q1/00 ,  C12Q1/32 ,  G01N31/22 ,  G01N33/52

CPC分类号： G01N33/525 ,  C12Q1/32 ,  Y10S435/805 ,  Y10S436/904

摘要： A dry analytical element having functional layers which contain dehydrogenase, oxidized nicotinamide coenzyme, pyruvate, an electron transport compound and an electron acceptable dye-forming compound is disclosed. The improvement the analytical element resides in that the coenzyme and dye-forming compound are contained in one or two layers which are different from a layer containing pyruvate.

摘要翻译： 公开了具有含有脱氢酶，氧化烟酰胺辅酶，丙酮酸盐，电子传递化合物和电子可接受的染料形成化合物的功能层的干燥分析元件。 分析元素的改进在于辅酶和染料形成化合物包含在不同于含有丙酮酸的层的一层或两层中。

公开(公告)号：US4919890A

公开(公告)日：1990-04-24

申请号：US177287

申请日：1988-04-04

申请人： Fuminori Arai ,  Fusae Osada

发明人： Fuminori Arai ,  Fusae Osada

IPC分类号： G01N33/52

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S436/81 ,  Y10T436/206664

摘要： A dry type analysis element for detecting a specific constituent in a liquid is provided. The dry type analysis element comprises a light-transmissive support having thereon at least one water-penetrative layer, at least one of said water-penetrative layer(s) containing a composition capable of interacting with said specific constituent in said liquid, wherein said composition contains a leuco dye comprising at least one compound selected from the group consisting of compounds represented formula [I] and salts of these compounds ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group, R.sup.2 represents a substituted or unsubustituted alkyl group, and R.sup.3 represents a substituted or unsubstituted aryl group,and said leuco dye is dissolved in a hydrophobic solvent to form a solution that is contained in said water-penetrative layer as a dispersion in a hydrophilic medium.

公开(公告)号：US4855109A

公开(公告)日：1989-08-08

申请号：US12693

申请日：1987-02-09

申请人： Katsuaki Muraishi ,  Nakatsugu Yaginuma ,  Kikuo Hirai ,  Fuminori Arai ,  Yuzo Iwata

发明人： Katsuaki Muraishi ,  Nakatsugu Yaginuma ,  Kikuo Hirai ,  Fuminori Arai ,  Yuzo Iwata

IPC分类号： G01N35/00

CPC分类号： G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00356 ,  G01N2035/00752 ,  Y10T436/11 ,  Y10T436/112499

摘要： A chemical analysis apparatus comprises a slide loading section for holding chemical analysis slides, a section for applying a sample material to the chemical analysis slide, and an incubator provided with housing compartments for housing the chemical analysis slides side by side in a transverse direction on the same plane. The apparatus also comprises a read-out head slideable in the transverse direction and disposed to face the chemical analysis slide housed in the housing compartment via a readout opening formed in each housing compartment, thereby emitting light to the chemical analysis slide and measuring the reflection optical density thereof. A conveyance and feed-in system is disposed for conveying the chemical analysis slide held at the slide loading section to the sample applying section, conveying the chemical analysis slide having a reagent layer with the sample material applied thereon to a position facing an inlet opening of the housing compartment, and then feeding the chemical analysis slide into the housing compartment from the inlet opening thereof.

摘要翻译： 化学分析装置包括用于保持化学分析载玻片的载玻片装载部分，将样品材料施加到化学分析载玻片的部分，以及设置有用于容纳化学分析的壳体隔室的培养箱，用于沿横向方向并排滑动 同一架飞机。 该装置还包括可沿横向滑动的读出头，其经由形成在每个容纳室中的读出开口面向容纳在容纳室中的化学分析滑块，从而向化学分析载玻片发射光并测量反射光学 密度。 输送和进料系统被设置用于将保持在滑动装载部分的化学分析载玻片输送到样品施加部分，将具有试剂层的化学分析载玻片输送到其上施加的样品材料到面向入口开口的位置 壳体隔室，然后将化学分析滑块从其入口开口进入壳体隔室。

公开(公告)号：US4671937A

公开(公告)日：1987-06-09

申请号：US626743

申请日：1984-07-02

申请人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

发明人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

IPC分类号： B32B7/02 ,  C12Q1/40 ,  G01N31/22 ,  G01N33/50 ,  G01N33/52 ,  C12R1/585 ,  C12R1/59 ,  C12R1/64

CPC分类号： C12Q1/40 ,  G01N33/525 ,  Y10S435/805 ,  Y10S436/81 ,  Y10S436/903 ,  Y10S436/904 ,  Y10S436/91

摘要： A multilayer analytical element for analysis of analyte in a liquid sample comprising a liquid sample-spreading layer, a reagent layer containing a diazonium salt, and a liquid-impermeable light-transmissive support, being laminated in this order, in which said reagent layer contains a sulfonic acid group-containing polymer having at least 10 molar % of a repeating unit selected from those consisting of a sulfoalkyl group and sulfophenyl group. The analytical element can be an element comprising a porous reagent layer containing a diazonium salt and the liquid-impermeable light-transmissive support, being laminated in this order.

摘要翻译： 用于分析液体样品中的分析物的多层分析元件，其包含液体样品扩散层，含有重氮盐的试剂层和不透液体的透光性载体，其中所述试剂层含有 具有至少10摩尔％的选自由磺基烷基和磺基苯基组成的重复单元的含磺酸基的聚合物。 分析元件可以是包含含有重氮盐的多孔试剂层和液体不可透过的透光性支撑体的元件，其顺序层叠。

公开(公告)号：US4578245A

公开(公告)日：1986-03-25

申请号：US534085

申请日：1983-09-20

申请人： Fuminori Arai ,  Yoshio Inagaki ,  Masao Kitajima

发明人： Fuminori Arai ,  Yoshio Inagaki ,  Masao Kitajima

IPC分类号： G01N33/92 ,  C12Q1/00 ,  C12Q1/28 ,  G01N31/22 ,  G01N33/52 ,  G01N21/78

CPC分类号： C12Q1/28 ,  G01N31/22 ,  G01N33/525 ,  C12Q2326/00 ,  C12Q2326/96

摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing a color forming reagent composition for detection of hydrogen peroxide including at least combination of a chromogen and a coupler (a color indicator composition), and peroxidase, which produces a detectable change in the presence of peroxidase and hydrogen peroxide, and a porous spreading layer, which are superposed in this order,in which said chromogen is a 1,2,3-tri-substituted compound of 4-amino-3-pyrazolin-5-one having solubility in water at 25.degree. C. of lower than that of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one.

摘要翻译： 一种多层分析元件，包括不透水的透光性载体，含有用于检测至少包括色原和成色剂的组合物的过氧化氢的成色剂组合物（颜色指示剂组合物）的试剂层和过氧化物酶， 在过氧化物酶和过氧化氢的存在下产生可检测的变化，以及以该顺序重叠的多孔扩散层，其中所述色原是4-氨基-3-吡唑啉的1,2,3-三取代化合物 -5-酮在25℃下在水中的溶解度低于4-氨基-2,3-二甲基-1-苯基-3-吡唑啉-5-酮的溶解度。

公开(公告)号：US4356149A

公开(公告)日：1982-10-26

申请号：US165444

申请日：1980-07-02

申请人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

发明人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

IPC分类号： G01N21/78 ,  C12Q1/58 ,  G01N31/22 ,  G01N33/52 ,  G01N33/62

CPC分类号： C12Q1/58 ,  G01N33/526 ,  Y10S435/805

摘要： A multi-layer chemical analytical material comprising a support, a reagent layer on the support and a spreading layer on the reagent layer wherein the reagent layer is composed of a hydrophilic binder and fine hydrophobic particles dispersed in the hydrophilic binder, said hydrophobic particles containing a reagent capable of directly or indirectly reacting with the component being analyzed to produce a color change.

摘要翻译： 一种多层化学分析材料，包括载体，载体上的试剂层和试剂层上的扩散层，其中试剂层由亲水性粘合剂和分散在亲水性粘合剂中的细疏水性颗粒构成，所述疏水性颗粒含有 能够直接或间接地与被分析的组分反应以产生颜色变化的试剂。

公开(公告)号：US4337222A

公开(公告)日：1982-06-29

申请号：US223062

申请日：1981-01-07

申请人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

发明人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

IPC分类号： G01N33/72 ,  G01N31/22 ,  G01N33/52

CPC分类号： G01N33/525

摘要： A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area.

摘要翻译： 一种血红蛋白浓度测定制品，其包含一体地设置在其上的不透水性支持体，依次是亲水性粘合剂层和具有亲水性表面的多孔扩散层，其中内部空隙或内部的表面是亲水性的和水 不溶性，所述多孔扩散层构成为使得施加到其上的水性样品能够以每单位面积的基本上确定的体积扩散并结合在其中。