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公开(公告)号：US20110104217A1
公开(公告)日：2011-05-05
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/16 , A61P17/02 , A61K38/08 , A61K38/10 , A61K9/00 , A61P9/00 , A61P9/04 , A61P9/12 , A61P7/02 , A61P9/10 , A61P19/02 , A61P1/04 , A61P11/06 , A61P29/00 , A61P25/00
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US20120129776A1
公开(公告)日：2012-05-24
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/08 , C07K14/47 , C07K7/08 , C07K2/00 , C07H21/00 , A61K48/00 , C07K16/18 , A61P9/12 , A61P9/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P3/00 , A61P11/00 , A61P17/02 , A61P19/08 , A61P13/02 , A61P15/00 , A61P7/00 , A61P37/00 , A61P35/00 , A61P13/12 , A61P17/14 , A61P21/00 , A61P9/04 , C07K19/00 , A61P7/02 , A61K38/17 , C07K7/06
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US20080182299A1
公开(公告)日：2008-07-31
申请号：US11978204
申请日：2007-10-29
申请人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
CPC分类号： G01N33/74 , C07K14/58 , G01N2800/324 , G01N2800/325 , Y10T436/143333
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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公开(公告)号：US20050277156A1
公开(公告)日：2005-12-15
申请号：US11043590
申请日：2005-01-27
申请人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
IPC分类号： A61K38/17 , C07K14/705 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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公开(公告)号：US09428586B2
公开(公告)日：2016-08-30
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , C12N15/113 , C12N9/24
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20120301475A1
公开(公告)日：2012-11-29
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： C07K16/40 , G01N33/573 , G01N33/574 , A61N5/00 , A61K39/395 , A61P35/00 , A61P35/02 , C12N5/20 , C12Q1/70
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US07601692B2
公开(公告)日：2009-10-13
申请号：US11471652
申请日：2006-06-21
申请人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
发明人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/523 , C12Q2600/156 , C12Q2600/158
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸，载体和包含其的宿主细胞的药物组合物。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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38.发明申请Novel thrombospondin-1 polynucleotides encoding variant thrombospondin-1 polypeptides and methods using same 审中-公开编码变体血小板反应蛋白-1多肽的新型血小板反应蛋白-1多核苷酸及其使用方法公开(公告)号：US20070219125A1
公开(公告)日：2007-09-20
申请号：US11709841
申请日：2007-02-23
申请人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
发明人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
IPC分类号： A61K38/36 , C07H21/04 , C07K14/745 , C07K16/36 , C12N5/10
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and phamaceutical compositions which can be used to treat various disorders such as cancer and retinopathies, using the polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于治疗各种疾病如癌症和视网膜病变的方法和药物组合物，使用本发明的多肽和多核苷酸。
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公开(公告)号：US20070092484A1
公开(公告)日：2007-04-26
申请号：US11471652
申请日：2006-06-21
申请人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
发明人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/523 , C12Q2600/156 , C12Q2600/158
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸的药物组合物，载体和包含其的宿主细胞。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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公开(公告)号：US07678769B2
公开(公告)日：2010-03-16
申请号：US11781905
申请日：2007-07-23
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
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