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公开(公告)号：US07678769B2
公开(公告)日：2010-03-16
申请号：US11781905
申请日：2007-07-23
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
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2.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 审中-公开肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20100183573A1
公开(公告)日：2010-07-22
申请号：US12709269
申请日：2010-02-19
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , A61K31/7088 , A61K35/74 , A61K35/66 , C12N1/19 , C12N5/10 , A61K35/64 , A61K35/12 , A61P35/02 , A61P9/10 , A61P37/00
CPC分类号： C07K14/71 , A61K38/00 , C07K16/248 , C07K2317/34 , C07K2317/55 , C07K2317/73
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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3.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 有权肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20080159992A1
公开(公告)日：2008-07-03
申请号：US11781905
申请日：2007-07-23
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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4.发明申请Methods and systems for identifying naturally occurring antisense transcripts and methods, kits and arrays utilizing same 审中-公开用于鉴定天然存在的反义转录物的方法和系统以及使用其的方法，试剂盒和阵列公开(公告)号：US20050009771A1
公开(公告)日：2005-01-13
申请号：US10764503
申请日：2004-01-27
申请人： Erez Levanon , Jeanne Bernstein , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Vladimir Grebinsky , Hanqing Xie , Brian Meloon , Andrew Olson , Dvir Dahary , Yossi Cohen , Avi Shoshan , Shira Walach , Alon Wasserman , Rami Khosravi , Galit Rotman
发明人： Erez Levanon , Jeanne Bernstein , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Vladimir Grebinsky , Hanqing Xie , Brian Meloon , Andrew Olson , Dvir Dahary , Yossi Cohen , Avi Shoshan , Shira Walach , Alon Wasserman , Rami Khosravi , Galit Rotman
CPC分类号： C12Q1/6876 , C12N15/111 , C12N2310/11 , C12N2320/11 , C12N2330/10 , C12Q2600/136 , C12Q2600/158 , G16B30/00 , Y02A50/58 , Y02A90/26
摘要： A method of identifying putative naturally occurring antisense transcripts is provided. The method is effected by (a) computationally aligning a first database including sense-oriented polynucleotide sequences with a second database including expressed polynucleotide sequences; and (b) identifying expressed polynucleotide sequences from the second database being capable of forming a duplex with at least one sense-oriented polynucleotide sequence of the first database, thereby identifying putative naturally occurring antisense transcripts. Also provided are polynucleotides and polypeptide sequences identified by the above-described methodology.
摘要翻译： 提供了鉴定推定的天然存在的反义转录物的方法。 该方法通过以下步骤来实现：（a）计算对齐包含有意向多核苷酸序列的第一数据库与包括表达的多核苷酸序列的第二数据库; 和（b）从第二数据库鉴定表达的多核苷酸序列能够与第一数据库的至少一个有义向多核苷酸序列形成双链体，从而鉴定推定的天然存在的反义转录物。 还提供了通过上述方法鉴定的多核苷酸和多肽序列。
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公开(公告)号：US20060068405A1
公开(公告)日：2006-03-30
申请号：US11043860
申请日：2005-01-27
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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公开(公告)号：US20110091454A1
公开(公告)日：2011-04-21
申请号：US12701651
申请日：2010-02-08
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P35/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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公开(公告)号：US20110183924A1
公开(公告)日：2011-07-28
申请号：US12662576
申请日：2010-04-23
申请人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
摘要： A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
摘要翻译： 注释生物分子序列的方法。 该方法包括（a）根据渐进同源范围计算聚集生物分子序列，从而产生多个具有同源范围的预定同源性的簇; 所述至少一个本体是：（i）从与每个簇的至少一个生物分子序列预先相关联的注释导出的;以及（b）将至少一个本体分配给所述多个簇中的每个簇， 和/或（ii）从每个簇的至少一个生物分子序列的分析产生，从而注释生物分子序列。
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公开(公告)号：US07745391B2
公开(公告)日：2010-06-29
申请号：US11443428
申请日：2006-05-31
申请人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
摘要： A human thrombospondin 1 protein, polynucleotide encoding the protein, and pharmaceutical composition thereof.
摘要翻译： 人类血小板反应蛋白1蛋白，编码蛋白质的多核苷酸及其药物组合物。
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公开(公告)号：US20070083334A1
公开(公告)日：2007-04-12
申请号：US11443428
申请日：2006-05-31
申请人： Liat Mintz , Hanqing Xie , Dvir Dahari , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Hermesh , Idit Azar , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahari , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Hermesh , Idit Azar , Jeanne Bernstein
IPC分类号： G06F19/00
摘要： A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
摘要翻译： 注释生物分子序列的方法。 该方法包括（a）根据渐进同源范围计算聚集生物分子序列，从而产生多个具有同源范围的预定同源性的簇; 所述至少一个本体是：（i）从与每个簇的至少一个生物分子序列预先相关联的注释导出的;以及（b）将至少一个本体分配给所述多个簇中的每个簇， 和/或（ii）从每个簇的至少一个生物分子序列的分析产生，从而注释生物分子序列。
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