公开(公告)号：US07388193B2

公开(公告)日：2008-06-17

申请号：US11157907

申请日：2005-06-22

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/40

CPC classification number: H01J49/025 ,  H01J49/061 ,  H01J49/40

Abstract: This invention provides an apparatus and method for efficient detection of ions in a time-of-flight mass spectrometer. The apparatus of the invention provides for orthogonal deflection of ions in the flight tube of a time of flight mass spectrometer to a detector or detectors positioned along or in the wall of the flight tube of the mass spectrometer. A method of detecting ions utilizing the apparatus is also provided.

Abstract translation: 本发明提供了一种用于在飞行时间质谱仪中有效检测离子的装置和方法。 本发明的装置提供了飞行时间质谱仪的飞行管中的离子与质谱仪的飞行管的沿着或位于其中的检测器或检测器的正交偏转。 还提供了利用该装置检测离子的方法。

公开(公告)号：US20080029696A1

公开(公告)日：2008-02-07

申请号：US11499177

申请日：2006-08-03

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/06

CPC classification number: H01J49/061

Abstract: The invention provides an ion extraction pulser. The ion extraction pulser may be used independently or in conjunction with a mass spectrometry system. The mass spectrometry system includes an ion source for producing ions, an ion optics system downstream from the ion source for selecting and directing ions, and a detector down stream from the ion optics system for detecting the ions selected and directed by the ion optics system. The ion optics system includes one or more ion extraction pulsers. The ion extraction pulser includes a mesh plate for applying a pulse for extracting ions from an ion beam; a first filter plate adjacent to the mesh plate for filtering ions extracted by the mesh plate; a guard plate adjacent to the first filter plate for further directing ions filtered by the first filter plate; and a second filter plate adjacent to the first guard plate for further filtering ions directed from the guard plateThe invention also provides methods for extracting, selecting and processing ions using ion extraction pulsers.

Abstract translation: 本发明提供一种离子提取脉冲发生器。 离子提取脉冲发生器可以独立使用或与质谱系统结合使用。 质谱系统包括用于产生离子的离子源，用于选择和引导离子的离子源下游的离子光学系统，以及用于检测由离子光学系统选择和引导的离子的离子光学系统的下游检测器。 离子光学系统包括一个或多个离子提取脉冲发生器。 离子提取脉冲发生器包括用于从离子束中提取离子的脉冲的网板; 与网板相邻的第一过滤板，用于过滤由网板提取的离子; 与所述第一过滤板相邻的防护板，用于进一步引导由所述第一过滤板过滤的离子; 以及与第一防护板相邻的第二过滤板，用于进一步过滤从防护板引导的离子。 本发明还提供了使用离子萃取脉冲发生器提取，选择和处理离子的方法。

公开(公告)号：US20070045532A1

公开(公告)日：2007-03-01

申请号：US11216884

申请日：2005-08-30

Applicant: Reid Brennen ,  Tom van de Goor ,  Gangqiang Li ,  Kevin Killeen

Inventor： Reid Brennen ,  Tom van de Goor ,  Gangqiang Li ,  Kevin Killeen

IPC: H01J49/10

CPC classification number: H01J49/10

Abstract: The invention described herein provides a mass spectrometry system, having an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, a second gas source for supplying gas at a defined flow to the ionization region, and a detector downstream from the ion source for detecting ions produced by the ion source. The invention also provides an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, and a second gas source for supplying gas at a defined flow to the ionization region. A method for producing analyte ions is also disclosed. The method includes producing analyte ions from an ionization device, directing a first heated gas toward the analyte ions to desolvate the analyte ions, and directing a second gas toward the analyte ions at a defined and continual flow rate.

Abstract translation: 本发明提供了一种质谱系统，其具有离子源，该离子源包括用于产生离子的离子化装置，与电离装置相邻的收集管，用于收集由离子化装置产生的离子;第一气体源，用于向产生的脱溶质离子供应气体 通过电离装置将用于以规定的流量供给到电离区域的气体的第二气体源和离子源下游的检测器，用于检测由离子源产生的离子。 本发明还提供一种离子源，其包括用于产生离子的离子化装置，与离子化装置相邻的收集管道，用于收集由离子化装置产生的离子，用于向离子化装置产生的脱溶质离子供给气体的第一气体源， 用于以限定的流量供应气体至电离区的第二气体源。 还公开了一种生产分析物离子的方法。 该方法包括从电离装置产生分析物离子，将第一加热气体引向分析物离子以使分析物离子脱溶质，并以限定和持续的流速将第二气体引向分析物离子。

公开(公告)号：US20070023646A1

公开(公告)日：2007-02-01

申请号：US11157906

申请日：2005-06-22

Applicant: Gangqiang Li ,  Alexander Mordehai

Inventor： Gangqiang Li ,  Alexander Mordehai

IPC: H01J49/00

CPC classification number: H01J49/424 ,  H01J49/4225 ,  H01J49/423

Abstract: An apparatus and method for correcting deviations in a quadrupole field in a quadrupole ion trap is provided. More specifically the invention provides for correction electrodes positioned in at least one primary quadrupole electrode and a method of using the correction electrodes to provide a field correction potential.

Abstract translation: 提供了用于校正四极离子阱中的四极场中的偏差的装置和方法。 更具体地，本发明提供了位于至少一个初级四极电极中的校正电极和使用校正电极提供场校正电位的方法。

公开(公告)号：US06759651B1

公开(公告)日：2004-07-06

申请号：US10405145

申请日：2003-04-01

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J4904

CPC classification number: H01J49/062

Abstract: Ion guides and systems and methods for involving the use of ion guides are disclosed. Briefly described, one exemplary system, among others, includes an ion guide. The ion guide includes a first structure and a second structure. The second structure is coaxially disposed within the first structure. The second structure includes at least three groups of opening the through a wall of the second structure that are distributed around a circumference of the second structure. In addition, at least one of the group of openings is offset from the other groups of openings by a multiple of a constant rotation angle around the circumference of the second structure.

Abstract translation: 公开了用于涉及使用离子导向器的离子导向器和系统和方法。 简要描述，一个示例性系统包括离子导向器。 离子导向器包括第一结构和第二结构。 第二结构同轴地设置在第一结构内。 第二结构包括至少三组打开第二结构的穿过第二结构的圆周分布的壁的组。 此外，该组开口中的至少一个与第二结构的圆周相距一定数量的旋转角度偏离另一组开口。

公开(公告)号：US06717133B2

公开(公告)日：2004-04-06

申请号：US09881606

申请日：2001-06-13

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J4900

CPC classification number: H01J49/40

Abstract: A method and apparatus for generating electrical fields within the ion flight path of a mass spectrometer are provided. Gratings having a planar array of parallel conductive strands and electrically connected to a voltage source are placed in the ion flight path so that at least a portion of the conductive strands traverses the flight path. The gratings may be arranged within the ion flight path so that the conductive strands of each of the gratings are aligned behind the conductive strands of a first grating, with respect to the ion flight path, thus providing high ion transmission.

Abstract translation: 提供了用于在质谱仪的离子飞行路径内产生电场的方法和装置。 具有平行阵列的并联导电线并电连接到电压源的光栅被放置在离子飞行路径中，使得至少一部分导电线穿过飞行路径。 光栅可以布置在离子飞行路径内，使得每个光栅的导电线相对于离子飞行路径在第一光栅的导电线之后对准，从而提供高离子透射。

公开(公告)号：US06274866B1

公开(公告)日：2001-08-14

申请号：US09334862

申请日：1999-06-17

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J4940

CPC classification number: H01J49/405

Abstract: The invention provides mass spectrometer systems, including time-of-flight mass spectrometers, and methods of performing mass spectroscopy. The systems are capable of operating in tandem or conventional mode. The systems include an ion reflector that, when operating in tandem mode, provides a discontinuous voltage to control the collision energy of the parent ions with the dissociation element. By controlling the collision energy, particular compositional information from the sample may be examined, such as specific bonding energies.

Abstract translation: 本发明提供了质谱仪系统，包括飞行时间质谱仪和进行质谱的方法。 这些系统能够以串联或常规模式运行。 该系统包括一个离子反射器，当串联模式工作时，提供不连续电压以控制母体离子与解离元件的碰撞能量。 通过控制碰撞能量，可以检查来自样品的特定组成信息，例如特定的结合能。

公开(公告)号：US06242735B1

公开(公告)日：2001-06-05

申请号：US09586258

申请日：2000-05-31

Applicant: Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

Inventor： Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

IPC: H01J4904

CPC classification number: H01J49/105

Abstract: A technique that modulates the power of a inductively coupled plasma (ICP) according to the operative modes of a spectrometer. An analytical apparatus of the present invention contains an inductively coupled plasma generator (ICPG) and a spectrometer. The ICPG generates a plasma for forming ionic and excited molecular species from a sample. The spectrometer analyzes the ionic and excited molecular species formed. The spectrometer operates in an analysis mode wherein the ionic and excited molecular species are identified according to physical characteristics of the species to provide data on the species and further has a washout mode wherein the spectrometer flushes out interfering ions and molecules and provides no significant data on the sample. The controller modulates the ICPG to operate in power cycles, at each cycle the ICPG operates in an analysis period and a stand-by period. By modulating the plasma power, the power consumption and heat dissipation can be reduced. When such a power modulated plasma source is coupled to, for example, a time-of-flight mass spectrometer (TOFMS), high analytical performance can be achieved with simultaneous multi-element detection capability.

公开(公告)号：US09236232B2

公开(公告)日：2016-01-12

申请号：US12627372

申请日：2009-11-30

Applicant: Stuart C. Hansen ,  Gangqiang Li

Inventor： Stuart C. Hansen ,  Gangqiang Li

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0404

Abstract: A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.

Abstract translation: 质谱仪系统，被配置为产生离子的离子源和被配置为从离子源接收至少一部分离子的非金属毛细管。 毛细管包括细长主体和在纵向方向上穿过细长主体的多个孔。 孔将接收到的离子通过毛细管运送到质谱仪系统的质谱仪进行检测。

公开(公告)号：US07939798B2

公开(公告)日：2011-05-10

申请号：US12363685

申请日：2009-01-30

Applicant: Gangqiang Li ,  Hongfeng Yin

Inventor： Gangqiang Li ,  Hongfeng Yin

IPC: H01J49/10

CPC classification number: H01J49/107 ,  H01J49/165

Abstract: An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

Abstract translation: 离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。 离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。 还描述了一种方法。