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    Bone substitute materials
    31.
    发明授权
    Bone substitute materials 失效
    骨替代材料

    公开(公告)号：US6136029A

    公开(公告)日：2000-10-24

    申请号：US942557

    申请日：1997-10-01

    申请人： Wesley D. Johnson ,  James R. Johnson ,  Jeffrey G. Marx

    发明人： Wesley D. Johnson ,  James R. Johnson ,  Jeffrey G. Marx

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/36 ,  A61F2/38 ,  A61L27/42 ,  A61L27/56

    CPC分类号： A61F2/28 ,  A61F2/30767 ,  A61L27/425 ,  A61L27/427 ,  A61L27/56 ,  A61F2/36 ,  A61F2/367 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30092 ,  A61F2002/30884 ,  A61F2002/30968 ,  A61F2210/0014 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00293 ,  A61L2430/02

    摘要： A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having open interconnecting interstices extending throughout said volume and opening through said surface. The article comprises a continuous strong framework structure having interstices which interconnect throughout the bulk volume and a second continuous material occupying at least a portion of the same bulk volume as the framework structure. The second material comprises an osteoinductive and/or osteoconductive composition. This composition may be present in one of several forms. One of these is as a coating on the surface of the framework structure. A second form is in the form of a composite, intimately mixed with the framework material within the framework struts. The third form is as a porous mass within the interstices of the framework structure, having pores which are interconnecting with themselves, and with the interstices of the framework structure. Desirably, the porous osteoinductive or osteoconductive composition extends throughout said bulk volume. In a preferred embodiment, the framework structure is formed of a ceramic material. In a further embodiment, the framework structure may be further structurally reinforced with a dense material component integrally affixed thereto.

    摘要翻译： 用作骨替代材料并具有限定具有本体体积的形状的外表面并且具有贯穿所述体积延伸并且穿过所述表面的开放互连间隙的强的多孔制品。 该制品包括具有互连整个本体体积的间隙的连续强框架结构和占据框架结构相同体积体积的至少一部分的第二连续材料。 第二种材料包括骨诱导和/或骨传导性组合物。 该组合物可以以几种形式之一存在。 其中之一是作为框架结构表面上的涂层。 第二种形式是复合物的形式，与框架支柱内的框架材料密切混合。 第三种形式是在框架结构的空隙内形成多孔质量，具有与其自身相互连接的孔隙以及框架结构的间隙。 期望地，多孔骨诱导或骨传导性组合物延伸贯穿整个体积。 在优选实施例中，框架结构由陶瓷材料形成。 在另一个实施例中，框架结构可以进一步在结构上用与其一体地固定的致密材料部件加强。