公开(公告)号：US11661431B2

公开(公告)日：2023-05-30

申请号：US17721636

申请日：2022-04-15

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore ,  Christopher J. Swank

IPC: C07D519/00 ,  C07D495/04 ,  A61P29/00

CPC classification number: C07D519/00 ,  C07D495/04

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20230102927A1

公开(公告)日：2023-03-30

申请号：US17724212

申请日：2022-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  David W. Lin ,  Michael L. Mitchell ,  Ezra Roberts ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D401/08 ,  C07D471/04 ,  A61K31/4439 ,  C07D491/048 ,  A61K31/497 ,  A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D409/14 ,  C07D493/08 ,  C07D493/10 ,  C07D417/14 ,  C07F9/6558 ,  A61K31/675

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20230021705A1

公开(公告)日：2023-01-26

申请号：US17723758

申请日：2022-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  Gediminas J. Brizgys ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Chao-I Hung ,  David W. Lin ,  Michael L. Mitchell ,  Ezra Roberts ,  Scott D. Schroeder ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: A61K31/5383 ,  C07D417/14 ,  C07D405/14 ,  C07D498/04 ,  C07D413/14 ,  C07D513/04 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  C07D401/14 ,  C07D491/08 ,  C07D495/04 ,  A61K45/06 ,  A61K31/423 ,  A61K31/137 ,  A61K31/357 ,  A61K31/135 ,  A61K38/22 ,  A61K31/5375 ,  A61K31/4188 ,  A61K35/60 ,  A61K31/4439 ,  A61K31/437 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/444 ,  A61K31/4995 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/4545 ,  C07D401/10 ,  A61K31/427 ,  A61K31/433 ,  C07D403/12

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US10654827B2

公开(公告)日：2020-05-19

申请号：US16016718

申请日：2018-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: A61K31/44 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/02

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US10442804B2

公开(公告)日：2019-10-15

申请号：US15885390

申请日：2018-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Eda Canales ,  Kevin S. Currie ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  Samuel E. Metobo ,  Roland D. Saito ,  Scott D. Schroeder ,  Nathan Shapiro ,  Winston C. Tse ,  Qiaoyin Wu ,  Yunfeng Eric Hu

IPC: C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  C07D519/00 ,  A61P31/20 ,  C07B59/00

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：US20190248807A1

公开(公告)日：2019-08-15

申请号：US16391673

申请日：2019-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chienhung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary B. Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/00 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180273508A1

公开(公告)日：2018-09-27

申请号：US15910083

申请日：2018-03-02

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/12 ,  C07D487/04 ,  A61K31/517 ,  A61K31/496 ,  A61K31/4725 ,  C07D491/052 ,  A61K31/4439 ,  A61K31/437 ,  A61K45/06 ,  A61K31/444 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D401/04 ,  C07D417/14 ,  C07D413/14 ,  A61K31/506

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20180251460A1

公开(公告)日：2018-09-06

申请号：US15885390

申请日：2018-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Eda Canales ,  Kevin S. Currie ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  Samuel E. Metobo ,  Roland D. Saito ,  Scott D. Schroeder ,  Nathan Shapiro ,  Winston C. Tse ,  Qiaoyin Wu

IPC: C07D471/14 ,  C07D498/14 ,  C07D519/00 ,  C07D491/22 ,  C07B59/00 ,  A61P31/20

CPC classification number: C07D471/14 ,  A61P31/20 ,  C07B59/002 ,  C07B2200/05 ,  C07D491/22 ,  C07D498/14 ,  C07D519/00

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：US09951043B2

公开(公告)日：2018-04-24

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-hung Chou ,  Michael Graupe ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/12 ,  C07D401/04 ,  C07D487/04 ,  C07D413/14 ,  C07D491/052 ,  C07D417/14 ,  C07D401/14 ,  C07D471/04 ,  C07D403/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20170152240A1

公开(公告)日：2017-06-01

申请号：US15429086

申请日：2017-02-09

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/14

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.