公开(公告)号：US12186748B2

公开(公告)日：2025-01-07

申请号：US17848864

申请日：2022-06-24

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Peiyun Wang ,  Pavel Kornilovich ,  Alexander Govyadinov ,  Noorashekin Binte Jamil ,  Sarita Jairam ,  Jinghua Zhao

IPC: B01L3/00 ,  G01N11/00

Abstract: An example self-priming microfluidic structure can include a microfluidic channel including a floor and a ceiling. A channel height is defined as a distance between the floor and the ceiling. A channel height step can be in the floor, or ceiling, or both. The channel height downstream of the channel height step can be greater than the channel height upstream of the channel height step. An interior pillar can be positioned in the microfluidic channel extending from the floor to the ceiling. The interior pillar can include a widening portion at an upstream end of the interior pillar and a tapering portion at a downstream end of the interior pillar. The interior pillar can overlap the channel height step so that the interior pillar is partially upstream of the channel height step and partially downstream of the channel height step.

公开(公告)号：US12145149B2

公开(公告)日：2024-11-19

申请号：US17415916

申请日：2019-03-08

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Diane R. Hammerstad ,  Alexander Govyadinov

IPC: B01L3/00

Abstract: A disposable microfluidic cassette can include a substrate and an engagement feature associated with the substrate to removably join the cassette with a cassette-receiver of an analytical system. A microfluidic network can be carried by the substrate. The microfluidic network can include a fluid inlet, a fluid outlet, and a sample manipulation portion fluidly coupling the fluid inlet to the fluid outlet. An ejector can be associated with the microfluidic network to move fluid out of the disposable microfluidic cassette via the fluid outlet.

公开(公告)号：US20240377324A1

公开(公告)日：2024-11-14

申请号：US18564531

申请日：2021-05-28

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Viktor Shkolnikov ,  Fausto D'Apuzzo

IPC: G01N21/64

Abstract: In one example in accordance with the present disclosure, a fluorescence detection system is described. The fluorescence detection system includes a microfluidic chamber to receive a sample containing a compound to be detected. An illumination system provides an excitation light to excite fluorophores in the microfluidic chamber. An outcoupler is disposed between the illumination system and the microfluidic chamber to diffuse the excitation light to fill the microfluidic chamber. The fluorescence detection system also includes a detection system to detect fluorescence generated by the excitation of the fluorophores in the microfluidic chamber.

公开(公告)号：US20240299942A1

公开(公告)日：2024-09-12

申请号：US18573690

申请日：2021-06-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Pavel Kornilovich ,  Alexander Govyadinov ,  Erik D. Torniainen ,  Richard W. Seaver ,  Anand Samuel Jebakumar

IPC: B01L3/00

CPC classification number: B01L3/502746 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/086

Abstract: A microfluidic device includes a chamber having a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has a leading surface or corner, a trailing surface or corner opposite the leading surface or corner, and trailing side surfaces adjoining the trailing surface or corner. Each pillar is oriented along a corresponding ray intersecting the leading surface or corner and the trailing surface or corner. Adjacent pillars have a turn angle between the corresponding rays of the adjacent pillars, and each pillar has a pillar angle between the trailing side surfaces thereof. The turn and pillar angles are based on a fluidic contact angle to promote fluid flow from the inlet throughout the chamber during priming without fluidic pinning.

公开(公告)号：US20240246084A1

公开(公告)日：2024-07-25

申请号：US18559761

申请日：2021-05-10

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Alexander Govyadinov ,  Richard W. Seaver ,  Erik D. Torniainen ,  Pavel Kornilovich ,  Anand Samuel Jebakumar

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/1805 ,  B01L2300/1894

Abstract: Apparatuses may be used for nucleic acid amplification. An example apparatus may include an amplification chamber to contain a biochemical reaction associated with amplification of a biologic sample. The biologic sample may include a nucleic acid. The apparatus may also include a heater thermally coupled to the amplification chamber. The apparatus may also include a thermally conductive substrate in contact with the heater and including a liquid coolant passage to pass a liquid coolant through the thermally conductive substrate.

公开(公告)号：US11988594B2

公开(公告)日：2024-05-21

申请号：US18196947

申请日：2023-05-12

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Pavel Kornilovich

IPC: G01N15/14 ,  B01L3/00 ,  G01N15/10 ,  H10N30/20

CPC classification number: G01N15/1484 ,  B01L3/50273 ,  H10N30/2047 ,  G01N2015/1006 ,  G01N2015/1028

Abstract: An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.

公开(公告)号：US20240033729A1

公开(公告)日：2024-02-01

申请号：US17876642

申请日：2022-07-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Viktor Shkolnikov

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L2200/16

Abstract: A reagent delivery network can include an inlet microfluidic channel, a microfluidic cross-channel branching off from the inlet microfluidic channel, a resistor positioned along the inlet microfluidic channel at a location to redirect fluid from the inlet microfluidic channel into the microfluidic cross-channel, and an outlet microfluidic channel having a side-wall opening connected to the microfluidic cross-channel. The outlet microfluidic channel can receive fluid from the microfluidic cross-channel. The microfluidic cross-channel can include a constriction region and a reagent storage chamber having reagent therein.

公开(公告)号：US11879844B2

公开(公告)日：2024-01-23

申请号：US17417533

申请日：2019-04-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Brett E. Dahlgren ,  Brian John Keefe

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6454 ,  G01N2021/6421

Abstract: An example device includes an array of sensor modules. A sensor module includes a body to be positioned in alignment with a planar target, a light source coupled to the body to emit light to the planar target along a source optical path, and a plurality of light sensors coupled to the body. Each light sensor is to sense a different wavelength of light received from the planar target along a sensor optical path. The sensor optical path is different from the source optical path. The bodies of the array of sensor modules are arranged in a planar tiling pattern with respect to a longitudinal axis of the planar target.

公开(公告)号：US20230280263A1

公开(公告)日：2023-09-07

申请号：US18196947

申请日：2023-05-12

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Pavel Kornilovich

IPC: G01N15/14 ,  B01L3/00 ,  H10N30/20

CPC classification number: G01N15/1484 ,  B01L3/50273 ,  H10N30/2047 ,  G01N2015/1006

Abstract: An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.

公开(公告)号：US20220162645A1

公开(公告)日：2022-05-26

申请号：US17414641

申请日：2019-07-25

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Viktor Shkolnikov ,  Alexander Govyadinov ,  Diane R. Hammerstad

IPC: C12N15/87 ,  C12M1/42 ,  C12M1/34 ,  C12M1/36 ,  B01L3/00 ,  G01V3/02 ,  G01N15/14 ,  G01N27/02

Abstract: In example implementations, an apparatus is provided. The apparatus includes a channel, a thermal inkjet (TIJ) resistor, and a transfection chamber. The TIJ resistor is to apply heat to a cell in the channel to porate the cell. The transfection chamber is to store a reagent to be inserted into the cell after the cell is porated.