公开(公告)号：US20240278240A1

公开(公告)日：2024-08-22

申请号：US18632183

申请日：2024-04-10

申请人： Cytek Biosciences, Inc.

发明人： Glen Krueger ,  David Vrane ,  Kuncheng Wang ,  Qiuta Gu

IPC分类号： B01L3/00 ,  C12M1/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1409 ,  G01N15/1434 ,  G01N15/149

CPC分类号： B01L3/502761 ,  B01L3/502715 ,  C12M47/04 ,  G01N15/14 ,  G01N15/1436 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1894 ,  G01N15/01 ,  G01N2015/1006 ,  G01N2015/1028 ,  G01N15/1409 ,  G01N15/149

摘要： Methods for a sorting flow cytometer system are disclosed. The method includes forming a stream of a sample biological fluid; charging the stream of the sample biological fluid with a first voltage having a first voltage polarity; breaking a first charged drop off of the stream, wherein the first charged drop is charged with the first voltage; dropping the first charged drop between a first electrostatic charge plate and a second electrostatic charge plate opposite the first electrostatic charge plate, wherein the first electrostatic charge plate and the second electrostatic charge plate are positioned on an angle to form a progressively larger gap between each; deflecting the first charged drop off of a center stream path towards the first electrostatic charge plate to drop along a line with a first angle; and orienting a first pivotal scupper to allow the first charged drop to fall into a first test tube.

公开(公告)号：US20240344958A1

公开(公告)日：2024-10-17

申请号：US18628507

申请日：2024-04-05

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Utkan Demirci ,  Waseem Asghar

IPC分类号： G01N15/10 ,  B01L3/00 ,  C12M3/00 ,  C12N5/071 ,  C12N5/076 ,  G01N1/40 ,  G01N15/00 ,  G01N15/01

CPC分类号： G01N15/10 ,  B01L3/502753 ,  C12N5/061 ,  C12N5/0612 ,  G01N1/4005 ,  G01N15/00 ,  C12M21/06 ,  G01N2001/4088 ,  G01N2015/0003 ,  G01N15/01 ,  G01N2015/1006 ,  G01N2015/1028 ,  G01N2800/367

摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.

公开(公告)号：US12111307B2

公开(公告)日：2024-10-08

申请号：US16973172

申请日：2019-06-10

申请人： INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOOD

发明人： Takehiko Fujino ,  Shiro Mawatari ,  Tsunemichi Kawa ,  Tetsuji Koyama ,  Toyoharu Yamashita

IPC分类号： G01N15/10 ,  G01N15/01 ,  G01N33/49

CPC分类号： G01N33/491 ,  G01N15/10 ,  G01N2015/012 ,  G01N2015/1006 ,  G01N2015/1028 ,  G01N2800/7042

摘要： A method for assessing aging of erythrocytes that includes preparing an erythrocyte suspension from a blood sample; allowing the erythrocyte suspension to pass through a first filter, separating aged erythrocytes that do not pass through the first filter, and non-aged erythrocytes that pass through the first filter, and to calculate a deformability of erythrocytes, allowing the separated non-aged erythrocyte suspension to pass through a second filter having micropores which diameter is smaller than the first filter, separating mild aged erythrocytes that do not pass through the second filter and juvenile erythrocytes that pass through the second filter, and to calculate a deformability of the non-aged erythrocytes; and assessing aging of erythrocytes, using the deformability of erythrocyte and the deformability of non-aged erythrocyte.

公开(公告)号：US20240288354A1

公开(公告)日：2024-08-29

申请号：US18570354

申请日：2022-01-13

申请人： Sony Group Corporation

发明人： Shota Yamamoto ,  Yasunobu Kato ,  Yudai Yanashita ,  Kenji Yamane

IPC分类号： G01N15/10 ,  G01N21/64

CPC分类号： G01N15/10 ,  G01N21/6486 ,  G01N2015/1028

摘要： An analysis result with high reproducibility can be obtained from multidimensional data by a particle analysis system including: a particle analysis apparatus including a light receiving unit that receives light emitted from a biologically derived particle; and an information processing apparatus including a dimensional compression unit that generates dimensionally compressed data by dimensionally compressing multidimensional data regarding the light output from the light receiving unit, and a learning unit that constructs a learning model by machine learning with a correspondence relationship between the dimensionally compressed data and the multidimensional data as a teacher.

公开(公告)号：US20240326037A1

公开(公告)日：2024-10-03

申请号：US18582489

申请日：2024-02-20

申请人： Northeastern University

发明人： Meni Wanunu ,  Ali Fallahi ,  Amr Khalid Makhamreh

IPC分类号： B01L3/00 ,  G01N15/10

CPC分类号： B01L3/502 ,  G01N15/1023 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/16 ,  B01L2400/0415 ,  B01L2400/0418 ,  G01N2015/1028

摘要： Systems and methods for controlled delivery of a specified quantity of particles. Systems involve a flow cell containing primary and secondary fluid chambers separated by a membrane, and a flow-producing module to induce particle translocation. Methods involve translocating particles between chambers through membrane activation, potentially for sorting and dispensing into target containers.

公开(公告)号：USRE50088E1

公开(公告)日：2024-08-20

申请号：US17514186

申请日：2021-11-12

申请人： Sony Corporation

发明人： Masataka Shinoda

IPC分类号： G01N15/1404 ,  B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N15/1434 ,  G01N27/447 ,  G01N15/10 ,  G01N15/1409 ,  G01N15/149

CPC分类号： G01N15/1404 ,  B01L3/0268 ,  B01L3/502761 ,  B01L3/502776 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N27/44743 ,  G01N27/44791 ,  B01L3/502746 ,  B01L2400/0433 ,  B01L2400/0487 ,  G01N2015/1006 ,  G01N2015/1028 ,  G01N15/1409 ,  G01N2015/1422 ,  G01N2015/1481 ,  G01N2015/1488 ,  G01N15/149 ,  Y10T137/8158

摘要： A microchip is provided that includes a flow path through which a liquid containing a micro particle flows, an orifice through which the liquid flowing through the flow path is discharged into a space outside the microchip, and a light-irradiated portion provided at a predetermined location of the flow path and configured to be irradiated with light. A width of the flow path and a depth of the flow path at the orifice are set to be smaller than a width of the flow path and a depth of the flow path at the light-irradiated portion, and the flow path is configured to gradually decrease from upstream of the orifice in a cross-section area perpendicular to a liquid-delivering direction between the light-irradiated portion and the orifice. A cartridge including the microchip is also provided.

公开(公告)号：US11988594B2

公开(公告)日：2024-05-21

申请号：US18196947

申请日：2023-05-12

申请人： Hewlett-Packard Development Company, L.P.

发明人： Alexander Govyadinov ,  Pavel Kornilovich

IPC分类号： G01N15/14 ,  B01L3/00 ,  G01N15/10 ,  H10N30/20

CPC分类号： G01N15/1484 ,  B01L3/50273 ,  H10N30/2047 ,  G01N2015/1006 ,  G01N2015/1028

摘要： An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.

公开(公告)号：US12036553B2

公开(公告)日：2024-07-16

申请号：US17418852

申请日：2019-05-03

申请人： MIKRO BIYOSISTEMLER ELEKTRONIK SANAYI VE TICARET A.S.

发明人： Gurhan Ozkayar ,  Ender Yildirim ,  Ozge Zorlu

IPC分类号： B01L3/00 ,  G01N15/10

CPC分类号： B01L3/502761 ,  B01L3/502746 ,  G01N15/10 ,  B01L2200/0652 ,  B01L2300/0883 ,  B01L2400/086 ,  G01N2015/1028

摘要： A method and a device for a microfluidic separation enhancement according to size of the particles to be separated are provided. An asymmetric obstacle in a shape of a cambered hydrofoil, placed at a downstream of a microfluidic channel increases a distance between particles of different sizes, wherein the particles have been partially separated at an upstream of the microfluidic channel, resulting an enhancement in the separation efficiency. Thus, microchannel length is decreased, resulting a decrease in hydraulic resistance and footprint of the microchannel.

公开(公告)号：US12025549B2

公开(公告)日：2024-07-02

申请号：US17414155

申请日：2019-05-13

申请人： Hewlett-Packard Development Company, L.P.

发明人： Viktor Shkolnikov ,  Alexander Govyadinov ,  Diane R. Hammerstad

IPC分类号： G01N15/12 ,  B01L3/00 ,  B81B7/02 ,  G01N15/10 ,  G01N15/1031 ,  G01N33/543

CPC分类号： G01N15/12 ,  B01L3/502761 ,  B81B7/02 ,  G01N15/1023 ,  G01N15/1031 ,  G01N33/54386 ,  B01L2200/025 ,  B01L2200/0652 ,  B01L2200/0663 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/14 ,  B01L2400/02 ,  B01L2400/0487 ,  G01N2015/1006 ,  G01N2015/1028

摘要： A system includes a microchannel analysis region, a first fluid actuation device, a second fluid actuation device, a sensor, and a controller. The first fluid actuation device is at a first end of the microchannel analysis region. The second fluid actuation device is at a second end of the microchannel analysis region opposite to the first end. The sensor is within the microchannel analysis region between the first fluid actuation device and the second fluid actuation device. The sensor measures an impedance of a fluid within the microchannel analysis region. The controller activates the first fluid actuation device to generate a first pressure wave in the fluid and activates the second fluid actuation device to generate a second pressure wave in the fluid. The first pressure wave and the second pressure wave converge at the sensor.

公开(公告)号：US12000770B2

公开(公告)日：2024-06-04

申请号：US17432484

申请日：2020-02-21

申请人： KYOCERA Corporation

发明人： Masashi Yoneta

IPC分类号： G01N15/10 ,  G01N15/01

CPC分类号： G01N15/1023 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1028

摘要： A particle separating and measuring device includes a first flow path device having a post-separation flow outlet to allow discharge of a first fluid containing target particles to be separated, and a second flow path device receiving the first flow path device and having a first flow inlet to receive the first fluid. The first flow path device having a lower surface having the post-separation flow outlet is on the second flow path device having an upper surface having the first flow inlet in a first region, with the post-separation flow outlet facing and connecting to the first flow inlet. A connection flow path vertically extends from an opening of the first flow inlet to a first flow path, and narrows from the opening of the first flow inlet toward the first flow path.