摘要:
A method and system for locating an opaque region, such as a heart region in a chest X-ray radiograph is disclosed. In order to segment a heart region in a chest X-ray radiograph, a heart region boundary is generated based on lung boundaries in the chest X-ray radiograph and an average heart region model. A location of the lower boundary of the heart region in the chest X-ray radiograph is then determined. Left and right portions of the heart region boundary are independently registered to corresponding portions of the lung boundaries, and upper and lower portions of the heart region boundary are adjusted based on the left and right portions in order to form a smooth contour.
摘要:
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要:
A method for directed machine learning includes receiving features including intensity data and location data of an image, condensing the intensity data and the location data into a feature vector, processing the feature vector by a plurality of classifiers, each classifier trained for a respective trained class among a plurality of classes, outputting, from each classifier, a probability of the feature vector belong to the respective trained class, and assigning the feature vector a label according to the probabilities of the classifiers, wherein the assignment produces a segmentation of the image.
摘要:
The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要:
A system for segmenting a target organ tumor from an image includes a background model builder, a foreground model builder and a tumor region locator. The background model builder uses an intensity distribution estimate of voxels in an organ region in an image to build a background model. The foreground model builder uses an intensity distribution estimate of voxels in a target organ tumor to build a first foreground model. The tumor region locator uses the background model and the first foreground model to segment the target organ tumor to obtain a first segmentation result.
摘要:
Detecting ground glass nodules in medical images includes calculating a probability distribution function of background lung tissue in a chest image, estimating a variation range of the background tissue probability distribution function, estimating a probability distribution function of an image point belonging to a ground glass nodule from the variation range of the background tissue probability distribution function by using a function corresponding to the variation range of the background tissue probability distribution function, and calculating a log likelihood function of the image from the background tissue probability distribution function and the estimated ground glass nodule probability distribution function, wherein the log likelihood function represents the confidence that a point in the image is not part of a ground glass nodule. The log likelihood function value for each point is compared to a confidence value of the background tissue, to determine if the point is a candidate ground glass nodule location.
摘要:
Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要:
Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要:
We present an algorithm for local surface smoothing in a defined Volume of Interest (“VOI”) cropped from three-dimensional (“3D”) volume data, such as lung computer tomography (“CT”) data. Because the VOI is generally a smooth and piecewise linear surface, the inclusion of one or more bumps may suggest an abnormality. In lung CT data, for example, such bumps can be nodules that are grown from the chest wall. The nodules may represent a possibility of lung cancer. Through surface smoothing, potential pathologies are separated from the surrounding anatomical structures. For example, nodules may be segmented from the chest wall. The separated pathologies can be analyzed as diagnostic evidence.
摘要:
The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.