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1.发明授权Niacin receptor agonists, compositions containing such compounds and methods of treatment 有权烟酸受体激动剂，含有这些化合物的组合物和治疗方法公开(公告)号：US08168649B2
公开(公告)日：2012-05-01
申请号：US11922629
申请日：2006-06-26
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/44 , A01N43/40 , A61K31/19 , A61K31/165
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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2.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20090042926A1
公开(公告)日：2009-02-12
申请号：US12086938
申请日：2006-12-20
申请人： Jason Imbriglio , Steven L. Colletti , James R. Tata , Richard T. Beresis , Daria Marley , Subharekha Raghavan , Darby Rye Schmidt , Ashley Rouse Lins , Abigail L. Smenton , Weichun Chen , Hong Shen , Fa-Xiang Ding , Rena Bodner
发明人： Jason Imbriglio , Steven L. Colletti , James R. Tata , Richard T. Beresis , Daria Marley , Subharekha Raghavan , Darby Rye Schmidt , Ashley Rouse Lins , Abigail L. Smenton , Weichun Chen , Hong Shen , Fa-Xiang Ding , Rena Bodner
IPC分类号： A61K31/4439 , C07C229/34 , C07D277/22 , C07D271/06 , C07D413/04 , A61K31/437 , A61P9/10 , A61P3/10 , C07D471/04 , A61K31/196 , A61K31/426 , A61K31/4245
CPC分类号： C07D277/28 , C07C237/20 , C07D231/12 , C07D263/32 , C07D271/06 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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3.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20120178750A1
公开(公告)日：2012-07-12
申请号：US13423618
申请日：2012-03-19
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/429 , A61K31/41 , A61K31/426 , A61K31/427 , A61K31/403 , A61K31/4375 , A61K31/437 , A61K31/538 , A61K31/4196 , A61P9/10 , A61P3/06 , A61P3/10 , A61P3/00 , A61K31/196
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式I化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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4.发明申请Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US20090209564A1
公开(公告)日：2009-08-20
申请号：US12225056
申请日：2007-03-19
申请人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Ashley Rouse Lins , Jiang Chang , Cangming Yang
发明人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Ashley Rouse Lins , Jiang Chang , Cangming Yang
IPC分类号： A61K31/505 , C07C233/78 , A61K31/192 , A61K31/47 , C07D215/06 , C07D239/34 , A61P3/10
CPC分类号： C07D215/06 , C07C229/52 , C07C233/83 , C07C235/42 , C07C255/57 , C07C309/65 , C07C309/66 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/10 , C07D213/30 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D215/20 , C07D215/227 , C07D231/12 , C07D231/56 , C07D235/18 , C07D239/34 , C07D257/06 , C07D261/08 , C07D263/57 , C07D271/10 , C07D271/12 , C07D277/64 , C07D277/68 , C07D285/14 , C07D307/42 , C07D307/79 , C07D307/81 , C07D311/12 , C07D311/58 , C07D333/54 , C07D333/60 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/12 , C07D491/04
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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5.发明授权Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US07989472B2
公开(公告)日：2011-08-02
申请号：US12225056
申请日：2007-03-19
申请人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Ashley Rouse Lins , Jiang Chang , Cangming Yang
发明人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Ashley Rouse Lins , Jiang Chang , Cangming Yang
IPC分类号： A61K31/47 , A61K31/4184 , C07D215/00 , C07D235/04
CPC分类号： C07D215/06 , C07C229/52 , C07C233/83 , C07C235/42 , C07C255/57 , C07C309/65 , C07C309/66 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/10 , C07D213/30 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D215/20 , C07D215/227 , C07D231/12 , C07D231/56 , C07D235/18 , C07D239/34 , C07D257/06 , C07D261/08 , C07D263/57 , C07D271/10 , C07D271/12 , C07D277/64 , C07D277/68 , C07D285/14 , C07D307/42 , C07D307/79 , C07D307/81 , C07D311/12 , C07D311/58 , C07D333/54 , C07D333/60 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/12 , C07D491/04
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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6.发明授权公开(公告)号：US07935713B2
公开(公告)日：2011-05-03
申请号：US12227030
申请日：2007-05-11
申请人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Cangming Yang , Ashley Rouse Lins
发明人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Cangming Yang , Ashley Rouse Lins
IPC分类号： A61K31/47 , A61K31/4184 , C07D215/00 , C07D235/04
CPC分类号： C07C233/83 , C07C235/42 , C07C323/60 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07D215/14 , C07D215/227 , C07D235/16 , C07D263/56
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
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7.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 有权烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20100144778A1
公开(公告)日：2010-06-10
申请号：US11922629
申请日：2006-06-26
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/437 , C07C233/02 , C07C229/38 , C07D413/04 , C07D513/04 , C07D471/14 , A61K31/165 , A61K31/192 , A61K31/4439 , A61K31/4245 , A61P9/10
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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8.发明申请Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds and Methods of Use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US20090105310A1
公开(公告)日：2009-04-23
申请号：US12227030
申请日：2007-05-11
申请人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Cangming Yang , Ashley Rouse Lins
发明人： Ronald M. Kim , Emma R. Parmee , Qiang Tan , Cangming Yang , Ashley Rouse Lins
IPC分类号： A61K31/4402 , C07D471/02 , C07C63/33 , C07D211/76 , A61K31/44 , A61P3/04 , C07D215/18 , A61K31/495 , A61K31/19
CPC分类号： C07C233/83 , C07C235/42 , C07C323/60 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07D215/14 , C07D215/227 , C07D235/16 , C07D263/56
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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