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    Flow Cytometer With Multiple Intensity Peak Design
    33.
    发明申请
    Flow Cytometer With Multiple Intensity Peak Design 审中-公开

    公开(公告)号：US20190391067A1

    公开(公告)日：2019-12-26

    申请号：US16467038

    申请日：2017-12-21

    Applicant: IMEC VZW

    Inventor： Dries Vercruysse ,  Peter Peumans

    IPC: G01N15/14

    Abstract: A sensing system comprises at least one fluidic channel (104) for providing at least one analyte (105) into at least one region of interest; at least one radiation transport system (501), for providing excitation radiation (103) for exciting analytes traversing the at least one region of interest; and a radiation collection system (301) for collecting any radiation signal emitted from the at least one region of interest. The at least one radiation transport system is adapted for providing excitation radiation comprising a plurality of excitation radiation intensity peaks (101, 102), whereby the distance between the excitation radiation intensity peaks is known. The sensing system comprises means (302, 303) for measurement of the speed of the at least one analyte within the fluidic channel (104), the means for measurement of speed comprising timing means (303) for obtaining the time between maxima in radiation signals emitted by the at least one analyte.

    Fluid analysis device
    34.
    发明授权
    Fluid analysis device 有权

    公开(公告)号：US10427156B2

    公开(公告)日：2019-10-01

    申请号：US15529424

    申请日：2015-11-24

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

    IPC: B01L3/00 ,  G01N1/14 ,  G01N1/38 ,  G01N33/49

    Abstract: The present disclosure relates to a fluid analysis device which comprises a sensing device for analyzing a fluid sample, the sensing device comprising a micro-fluidic component for propagating the fluid sample and a microchip configured for sensing the fluid sample in the micro-fluidic component; a sealed fluid compartment containing a further fluid, the compartment being fluid-tight connected to the sensing device and adapted for providing the further fluid to the micro-fluidic component when the sealed fluid compartment is opened; and an inlet for providing the fluid sample to the micro-fluidic component. Further, the present disclosure relates to a method for sensing a fluid sample using the fluid analysis device.

    Bleaching of Dyes in Luminescent Detection
    35.
    发明申请
    Bleaching of Dyes in Luminescent Detection 审中-公开

    公开(公告)号：US20180172588A1

    公开(公告)日：2018-06-21

    申请号：US15736457

    申请日：2016-06-30

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

    IPC: G01N21/64

    CPC classification number: G01N21/6408 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6413 ,  G01N2021/6439

    Abstract: Sensor devices for quantifying luminescent targets are described herein. An example device comprises a light source for exciting the targets, thus generating luminescence signals and a detector for detecting these signals, resulting in a detected signal which comprises a desired signal originating from the targets and a background signal. It moreover comprises a bleaching device for bleaching of at least part of the sources generating the background signal and a processor configured to trigger the bleaching device to start bleaching, and to trigger the light source for exciting the remaining luminescent targets which are not bleached, and to trigger the detector for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

    Time, Space Digitally Resolved Quantification of Luminescent Targets
    36.
    发明申请
    Time, Space Digitally Resolved Quantification of Luminescent Targets 审中-公开

    公开(公告)号：US20180172587A1

    公开(公告)日：2018-06-21

    申请号：US15736414

    申请日：2016-06-22

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

    IPC: G01N21/64

    CPC classification number: G01N21/6408 ,  G01N21/6456 ,  G01N21/648

    Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.

    Integrated fluorescence detection
    37.
    发明授权
    Integrated fluorescence detection 有权
    综合荧光检测

    公开(公告)号：US09146235B2

    公开(公告)日：2015-09-29

    申请号：US14570675

    申请日：2014-12-15

    Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

    Inventor： Pol Van Dorpe ,  Sarp Kerman ,  Peter Peumans ,  Willem Van Roy

    IPC: G01N21/64 ,  G01N21/77 ,  G01N33/50 ,  G01N33/543

    CPC classification number: G01N33/54373 ,  G01N15/1436 ,  G01N15/1456 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7743 ,  G01N2015/1006 ,  G01N2021/6482 ,  G01N2021/7786

    Abstract: An integrated fluorescence detector for detecting fluorescent particles is described. An example integrated fluorescence detector comprises a substrate, the substrate comprising an integrated detection element for detecting fluorescence radiation from fluorescent particles upon excitation of the particles with incident excitation radiation. The integrated fluorescence detector also comprises a sensing layer adapted for accommodating fluorescent particles to be sensed. The integrated fluorescence detector further comprises a photonics crystal layer arranged in between the sensing layer and the substrate, the photonics crystal layer comprising an absorption material designed such that the photonics crystal layer is configured for diffracting incident excitation radiation into a lateral direction in which the photonics crystal layer extends for incident excitation radiation having a wavelength within at least 10 nm of the predetermined excitation wavelength.

    Abstract translation: 描述了用于检测荧光颗粒的集成荧光检测器。 示例性的集成荧光检测器包括衬底，该衬底包括用于在用入射激发辐射激发颗粒时检测来自荧光颗粒的荧光辐射的集成检测元件。 集成荧光检测器还包括适于容纳要感测的荧光颗粒的感测层。 集成荧光检测器还包括布置在感测层和衬底之间的光子晶体层，光子晶体层包括设计成使得光子晶体层被配置为将入射激发辐射衍射到横向方向的吸收材料，其中光子 晶体层对于具有在预定激发波长的至少10nm内的波长的入射激发辐射延伸。

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