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31.发明授权公开(公告)号：US10760043B2
公开(公告)日：2020-09-01
申请号：US16823269
申请日：2020-03-18
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Richard Fox , Phillip Belgrader , Don Masquelier
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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公开(公告)号：US10745678B1
公开(公告)日：2020-08-18
申请号：US16868462
申请日：2020-05-06
Applicant: Inscripta, Inc.
Inventor： Juhan Kim , Benjamin Mijts , Aamir Mir , Andrew Garst , Kyle Seamon
Abstract: The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.
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33.发明申请公开(公告)号：US20200216794A1
公开(公告)日：2020-07-09
申请号：US16820292
申请日：2020-03-16
Applicant: Inscripta, Inc.
Inventor： Phillip Belgrader , Don Masquelier , Andrew Garst , Richard Fox
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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公开(公告)号：US10604746B1
公开(公告)日：2020-03-31
申请号：US16658948
申请日：2019-10-21
Applicant: Inscripta, Inc.
Inventor： Benjamin Mijts , Juhan Kim , Aamir Mir , Kyle Seamon , Andrew Garst
IPC: C12N9/22
Abstract: The present disclosure provides engineered RNA-guided enzymes for editing live cells.
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35.发明申请公开(公告)号：US20200095533A1
公开(公告)日：2020-03-26
申请号：US16597831
申请日：2019-10-09
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Richard Fox , Phillip Belgrader , Don Masquelier
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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Patent Agency Ranking
36.发明授权公开(公告)号：US10533152B1
公开(公告)日：2020-01-14
申请号：US16399988
申请日：2019-04-30
Applicant: Inscripta, Inc.
Inventor： Phillip Belgrader , Don Masquelier , Bruce Chabansky , Jorge Bernate , Andrew Garst , Richard Fox
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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公开(公告)号：US10017760B2
公开(公告)日：2018-07-10
申请号：US15632222
申请日：2017-06-23
Inventor： Ryan T. Gill , Andrew Garst , Tanya Elizabeth Warnecke Lipscomb , Marcelo Colika Bassalo , Ramsey Ibrahim Zeitoun
IPC: C12N15/09 , C12N15/10 , C12N15/11 , C12N15/63 , C12N15/64 , C12N15/70 , C12N15/74 , C12N15/79 , C12N15/81 , C12N15/82 , C12N15/85
CPC classification number: C12N15/1065 , C12N15/102 , C12N15/1079 , C12N15/1082 , C12N15/11 , C12N2310/20 , C12Q2563/179
Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
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公开(公告)号：US20230227810A1
公开(公告)日：2023-07-20
申请号：US18157740
申请日：2023-01-20
Applicant: Inscripta, Inc.
Inventor： Ryan T. Gill , Andrew Garst , Tanya Elizabeth Warnecke Lipscomb , Marcelo Colika Bassalo , Ramsey Ibrahim Zeitoun
CPC classification number: C12N15/1065 , C12N15/11 , C12N15/102 , C12N15/1082 , C12N15/1079 , C12N2310/20
Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
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公开(公告)号：US11685889B2
公开(公告)日：2023-06-27
申请号：US17734037
申请日：2022-04-30
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Richard Fox , Eileen Spindler , Amy Hiddessen , Phillip Belgrader , Don Masquelier , Bruce Chabansky , Michael Graige
CPC classification number: C12M35/08 , C12M23/44 , C12M33/14 , C12N15/11 , C12N15/902 , C12N2310/20
Abstract: The present disclosure provides automated modules and instruments for improved detection of nuclease genome editing of live cells. The disclosure provides improved modules—including high throughput modules—for screening cells that have been subjected to editing and identifying and selecting cells that have been properly edited.
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公开(公告)号：US20220315907A1
公开(公告)日：2022-10-06
申请号：US17639022
申请日：2020-10-01
Applicant: Inscripta, Inc.
Inventor： Andrew Garst
Abstract: The present disclosure provides compositions and methods to increase the percentage of edited cells in a cell population when employing nucleic-acid guided editing, as well as automated multi-module instruments for performing these methods.
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