利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

281 条记录 (耗时 0.039 秒)

    RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
    33.
    发明申请
    RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) 审中-公开
    使用短干扰核酸（siNA）的RNA干扰介导的蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的抑制

    公开(公告)号：US20060019913A1

    公开(公告)日：2006-01-26

    申请号：US11031668

    申请日：2005-01-06

    申请人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    发明人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    IPC分类号： A61K48/00 ,  C07H21/02

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K49/0008 ,  C12N15/87 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3519 ,  C12N2310/53 ,  C12Y301/03048 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PTP-1B genes. Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing obesity, insulin resistance, diabetes (eg. type II and type I diabetes) in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of PTP-1B in a cell or tissue, alone or in combination with other treatments or therapies.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节涉及PTP-1B基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节PTP-1B基因表达的方法。 这样的小核酸分子可用于例如治疗，预防，抑制或减少受试者或生物体内的肥胖，胰岛素抵抗，糖尿病（例如II型和I型糖尿病）和任何其它疾病，性状， 或与细胞或组织中PTP-1B水平相关或将会对其单独或与其它治疗或疗法组合相关的病症。

    RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    36.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
    RNA干扰介导的抑制蛋白酪氨酸磷酸化酶-1B（PTP-1B）基因表达使用短暂的核酸（siNA）

    公开(公告)号：US20090239931A1

    公开(公告)日：2009-09-24

    申请号：US11748029

    申请日：2007-05-14

    申请人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    发明人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    IPC分类号： A61K31/7105

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K49/0008 ,  C12N15/87 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3519 ,  C12N2310/53 ,  C12Y301/03048 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PTP-1B genes. Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing obesity, insulin resistance, diabetes (eg. type II and type I diabetes) in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of PTP-1B in a cell or tissue, alone or in combination with other treatments or therapies.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节涉及PTP-1B基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节PTP-1B基因表达的方法。 这样的小核酸分子可用于例如治疗，预防，抑制或减少受试者或生物体内的肥胖，胰岛素抵抗，糖尿病（例如II型和I型糖尿病）和任何其它疾病，性状， 或与细胞或组织中PTP-1B水平相关或将会对其单独或与其它治疗或疗法组合相关的病症。