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    Implantable cardiac stimulation device and method utilizing electrogram spectral analysis for therapy administration
    31.
    发明授权
    Implantable cardiac stimulation device and method utilizing electrogram spectral analysis for therapy administration 失效
    可植入式心脏刺激装置及利用电针谱分析进行治疗的方法

    公开(公告)号：US06622042B1

    公开(公告)日：2003-09-16

    申请号：US09852884

    申请日：2001-05-09

    Applicant: James R. Thacker

    Inventor： James R. Thacker

    IPC: A61N1365

    CPC classification number: A61N1/3622 ,  A61N1/3684 ,  A61N1/3962

    Abstract: An implantable cardiac stimulation device and method utilizes electrogram spectral analysis to administer electrical stimulation therapy to a heart to treat accelerated arrhythmias of the heart. The device includes an arrhythmia detector that initially detects an accelerated arrhythmia of the heart. An acquisition system then acquires an electrogram of the heart having both atrial and ventricular depolarization components. A processor then spectral analyzes the electrogram to provide spectral data related to the accelerated arrhythmia. The spectral data may be used for arrhythmia discrimination, arrhythmia tolerance discernment, and/or by a pulse generator to control stimulation therapy delivery timing.

    Abstract translation: 可植入心脏刺激装置和方法利用电描记图谱分析来对心脏进行电刺激治疗以治疗心脏加速的心律失常。 该装置包括心律失常检测器，该检测器最初检测到心脏加速的心律失常。 然后，获取系统获取具有心房和心室去极化组件的心脏的电描记图。 然后，处理器对光电图进行光谱分析，以提供与加速心律失常相关的光谱数据。 频谱数据可以用于心律失常鉴别，心律失常容忍辨别，和/或通过脉冲发生器来控制刺激治疗递送时机。

    Method for making a body implantable sensor
    32.
    发明授权
    Method for making a body implantable sensor 失效
    制造人体植入式传感器的方法

    公开(公告)号：US5490323A

    公开(公告)日：1996-02-13

    申请号：US380764

    申请日：1995-01-30

    Applicant: James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

    Inventor： James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

    IPC: A61B5/145 ,  A61B5/1459 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37 ,  H01R43/00

    CPC classification number: A61N1/056 ,  A61N1/36557 ,  A61N1/3702 ,  Y10T29/49117

    Abstract: The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

    Abstract translation: 本发明包括具有多极近端连接器的主体可植入引线，至少一个耦合到至少一个刺激电极的第一导体，用于感测身体的至少一个生理参数的传感器，以及耦合到该主体的第二和第三导体 传感器。 传感器密封在D形外壳中。 传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。 用密封环（玻璃料或金属）的端盖用于密封外壳的端部。 通过加热密封材料直到它们在端盖和壳体之间再流动，容易实现气密密封。 有利地，传感器端子的尺寸设计成紧密地配合在端盖的窄孔内，然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。 至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。 有利地，D形壳体将需要被密封的面积减少一半以上，从而减小了导线的总直径。 有利地，耦合到传感器的导体独立于刺激导体起作用，从而防止对起搏器的基本操作的干扰。

    Apparatus and method for determining the relative position and orientation of neurostimulation leads
    33.
    发明授权
    Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
    用于确定神经刺激导联的相对位置和取向的装置和方法

    公开(公告)号：US09192760B2

    公开(公告)日：2015-11-24

    申请号：US12856905

    申请日：2010-08-16

    Applicant: Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

    Inventor： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

    IPC: A61N1/00 ,  A61N1/08 ,  A61N1/05 ,  A61B5/053

    CPC classification number: A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

    Abstract: A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

    Abstract translation: 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。

    Systems and methods for detecting intrathecal penetration
    35.
    发明授权
    Systems and methods for detecting intrathecal penetration 有权
    检测鞘内渗透的系统和方法

    公开(公告)号：US08805519B2

    公开(公告)日：2014-08-12

    申请号：US12895438

    申请日：2010-09-30

    Applicant: Jon Parker ,  James R. Thacker

    Inventor： Jon Parker ,  James R. Thacker

    IPC: A61N1/00 ,  A61N1/36 ,  A61B5/053

    CPC classification number: A61N1/36142 ,  A61B5/0538 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36071

    Abstract: Systems and methods for detecting intrathecal penetration are disclosed. A method in accordance with one embodiment includes detecting a value corresponding to an impedance of an electrical circuit that in turn includes an electrical contact located within the patient, and patient tissue adjacent to the electrical contact. The method further includes comparing the detected value to a predetermined criterion, and, if the detected value meets the predetermined criterion, identifying penetration of the patient's dura based at least in part on the detected value.

    Abstract translation: 公开了用于检测鞘内渗透的系统和方法。 根据一个实施例的方法包括检测对应于电路的阻抗的值，该电阻的阻抗又包括位于患者体内的电触点以及与电触点相邻的患者组织。 该方法还包括将检测值与预定标准进行比较，并且如果检测值符合预定标准，则至少部分地基于检测值来识别患者硬脑膜的穿透。

    Apparatus and method for determining the relative position and orientation of neurostimulation leads
    36.
    发明授权
    Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
    用于确定神经刺激导联的相对位置和取向的装置和方法

    公开(公告)号：US08682447B2

    公开(公告)日：2014-03-25

    申请号：US11343007

    申请日：2006-01-30

    Applicant: Kerry Bradley ,  James R. Thacker

    Inventor： Kerry Bradley ,  James R. Thacker

    IPC: A61N1/00

    CPC classification number: A61N1/08 ,  A61B5/053 ,  A61N1/0551

    Abstract: Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values.

    Abstract translation: 使用内电极阻抗或电场电位测量来确定一个引线与脊柱或其他身体/组织位置中的其它引线的相对取向。 内部电阻阻抗通过测量阻抗矢量来确定。 阻抗矢量的值主要是由于电极 - 电解质界面和电极之间的体阻抗。 电极之间的体阻抗又由（1）与电极相邻的组织的阻抗，和（2）电极之间的组织的阻抗构成。 在一个实施例中，本发明进行单极性和双极性阻抗测量，然后使用单极测量来校正双极性阻抗测量，以消除邻近电极的组织的阻抗的影响。 引线的取向和位置可以从校正的双极性阻抗值的相对最小值推断。 这些校正的阻抗值也可以被映射和存储，以便于与随后校正的阻抗测量值进行比较。

    Neural stimulation lead fixation
    37.
    发明授权
    Neural stimulation lead fixation 有权
    神经刺激铅固定

    公开(公告)号：US08295945B1

    公开(公告)日：2012-10-23

    申请号：US11464109

    申请日：2006-08-11

    Applicant: James R. Thacker ,  Michael S Colvin ,  David K. L. Peterson ,  James P. McGivern

    Inventor： James R. Thacker ,  Michael S Colvin ,  David K. L. Peterson ,  James P. McGivern

    IPC: A61N1/05

    CPC classification number: A61N1/0558 ,  A61M25/1002 ,  A61M25/1011

    Abstract: An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

    Abstract translation: 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

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