公开(公告)号：US20100305631A1

公开(公告)日：2010-12-02

申请号：US12856905

申请日：2010-08-16

申请人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

发明人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

IPC分类号： A61N1/08

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。

公开(公告)号：US07657317B2

公开(公告)日：2010-02-02

申请号：US11115789

申请日：2005-04-26

申请人： James R. Thacker ,  Carla M. Woods ,  Sridhar Kothandaraman ,  John D. H. King ,  Kerry Bradley

发明人： James R. Thacker ,  Carla M. Woods ,  Sridhar Kothandaraman ,  John D. H. King ,  Kerry Bradley

IPC分类号： A61N1/36

CPC分类号： G06F19/3481 ,  A61N1/36071 ,  G06F19/00 ,  G16H40/63

摘要： A tissue stimulation system is provided that evaluates and/or scores stimulation sets based on both patient feedback and frequency of use. Stimulation sets and any associated scores and/or usage may be stored in a retrievable database. Upon subsequent stimulation sessions, a patient may select stimulation sets that have a high score and/or usage in order to effectively meet therapeutic objectives. Methods of determining patient satisfaction, which involve evaluating patient pain before and after stimulation pulses are applied, are also provided herein.

摘要翻译： 提供组织刺激系统，其基于患者反馈和使用频率来评估和/或评估刺激组。 刺激集和任何相关的分数和/或使用可以存储在可检索的数据库中。 在随后的刺激会话中，患者可以选择具有高得分和/或使用的刺激组，以便有效地满足治疗目标。 本文还提供了确定患者满意度的方法，其涉及在刺激脉冲之前和之后评估患者疼痛。

公开(公告)号：US20080125833A1

公开(公告)日：2008-05-29

申请号：US11938490

申请日：2007-11-12

申请人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

发明人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

IPC分类号： A61N1/08

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。

公开(公告)号：US07363079B1

公开(公告)日：2008-04-22

申请号：US10672660

申请日：2003-09-25

申请人： James R Thacker ,  Kerry Bradley

发明人： James R Thacker ,  Kerry Bradley

IPC分类号： A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/36185 ,  A61N1/378

摘要： At least one system and at least one method permit a clinician to view or hear power consumption data during a Spinal Cord Stimulation (SCS) system fitting procedure. For example, a clinician's programming computer includes a display of power consumption for each effective stimulation configuration under evaluation during fitting. A clinician performing the fitting procedure uses a programming computer to select various stimulation configurations. The power consumption of the SCS configuration(s) presently and/or previously exercised is displayed for the clinician. By comparing the power consumption for each configuration, the clinician may select a configuration consuming less power while providing effective therapy. Suggestions for low power configurations may be provided by the programming computer.

摘要翻译： 至少一个系统和至少一种方法允许临床医生在脊髓刺激（SCS）系统拟合过程期间查看或听到功率消耗数据。 例如，临床医生的编程计算机包括在装配期间评估的每个有效刺激配置的功率显示。 执行装配程序的临床医生使用编程计算机来选择各种刺激配置。 为临床医生显示当前和/或以前行使的SCS配置的功耗。 通过比较每个配置的功耗，临床医生可以选择消耗较少功率的配置，同时提供有效的治疗。 低功耗配置的建议可以由编程计算机提供。

公开(公告)号：US09511229B2

公开(公告)日：2016-12-06

申请号：US13533532

申请日：2012-06-26

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61B5/053 ,  A61N1/08 ,  A61B5/06

CPC分类号： A61N1/08 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/068 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36182 ,  A61N1/37217 ,  A61N1/37241 ,  A61N1/3787

摘要： A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.

摘要翻译： 用于在患者体内植入神经刺激引线的方法包括测量引线上的电极的阻抗，以便使引线相对于目标组织区域正确定位。 电极是周向分段的电极，其围绕导线的纵向轴线彼此间隔开。 当电极的阻抗差超过阈值时，引线处于正确的位置。 根据另一个实施例，使用阻抗测量来选择哪个电极最靠近目标组织区域。 通过确定哪个电极具有最高阻抗并且哪个电极具有最低的阻抗，可以基于组织的电导率特性来确定与每个电极相邻的组织的类型。 目标组织区域可以是脊髓，后纵韧带，白质或灰质。

公开(公告)号：US08923974B2

公开(公告)日：2014-12-30

申请号：US13469880

申请日：2012-05-11

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0551 ,  A61N1/36071

摘要： A method for treating a patient having discogenic pain includes implanting a neurostimulation lead within an anterior portion of the epidural space adjacent to the posterior longitudinal ligament. A plurality of electrodes is attached to the lead and the lead is implanted with at least a portion of the electrodes facing the posterior longitudinal ligament. The lead may be implanted in the lumbar region of the patient's spine, posterior and parallel to the posterior longitudinal ligament. Electrical stimulation energy applied to the patient through the electrode lead implanted in this manner inhibits the pain signals traveling within the posterior longitudinal ligament. Thus, the applied electrical stimulation energy has an anesthetic effect on the pain fibers adjacent to the posterior longitudinal ligament.

摘要翻译： 用于治疗具有椎间性疼痛的患者的方法包括将神经刺激引线植入在与后纵韧带相邻的硬膜外腔的前部中。 多个电极附接到引线，并且引线被注入，电极的至少一部分面向后纵向韧带。 铅可以植入患者脊柱的腰部区域，后部并且平行于后纵韧带。 通过以这种方式植入的电极引线施加到患者的电刺激能量抑制在后纵韧带内行进的疼痛信号。 因此，所施加的电刺激能量对与后纵韧带相邻的疼痛纤维具有麻醉作用。

公开(公告)号：US08718757B2

公开(公告)日：2014-05-06

申请号：US13367163

申请日：2012-02-06

申请人： Kerry Bradley ,  Sunil K. Kapoor

发明人： Kerry Bradley ,  Sunil K. Kapoor

IPC分类号： A61N1/00

CPC分类号： A61N1/37241 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36185 ,  A61N2001/083

摘要： Apparatus and methods for detecting lead migration through the use of measured artifactual data about the tissue in the vicinity of the lead.

摘要翻译： 通过使用关于铅附近的组织的测量的人为因素来检测引线迁移的装置和方法。

公开(公告)号：US20120330391A1

公开(公告)日：2012-12-27

申请号：US13529906

申请日：2012-06-21

申请人： Kerry Bradley ,  Dongchul Lee

发明人： Kerry Bradley ,  Dongchul Lee

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/36067 ,  A61N1/36171 ,  A61N1/36175

摘要： A method for using spinal cord stimulation to treat symptoms of motor disorders includes implanting a stimulation lead within a ventral portion of the epidural space. The lead is implanted with at least a portion of the electrodes facing the spinal cord. In a method for providing therapy to a patient suffering from a motor disorder, electrical stimulation energy is applied to at least one ventral column nerve fiber through the implanted stimulation lead. A peripheral region of the patient's body exhibits the symptoms of the motor disorder, and the ventral column nerve fiber to which the stimulation is applied innervates that peripheral region.

摘要翻译： 使用脊髓刺激来治疗运动障碍症状的方法包括将刺激引线植入硬膜外腔的腹侧部分。 植入铅的至少一部分电极面向脊髓。 在向患有运动障碍的患者提供治疗的方法中，通过植入的刺激引线向至少一个腹侧神经纤维施加电刺激能量。 患者身体的周边区域表现出运动障碍的症状，并且施加刺激的腹侧柱神经纤维支配该外周区域。

公开(公告)号：US20100125315A1

公开(公告)日：2010-05-20

申请号：US12606065

申请日：2009-10-26

申请人： Jordi Parramon ,  David K.L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

发明人： Jordi Parramon ,  David K.L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

IPC分类号： A61N1/00

CPC分类号： A61N1/36125 ,  A61N1/0551 ,  A61N1/36157 ,  A61N1/36185

摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.

摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动 分别与一个或多个电路径相关联。

公开(公告)号：US20100125314A1

公开(公告)日：2010-05-20

申请号：US12606050

申请日：2009-10-26

申请人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

发明人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

IPC分类号： A61N1/08

CPC分类号： A61N1/36192 ,  A61N1/36071 ,  A61N1/37247

摘要： A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device causes an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.

摘要翻译： 提供刺激神经组织，组织刺激系统和外部控制装置的方法。 该方法，系统和控制装置使得电刺激被施加到邻近患者神经组织的至少一个电极。 所施加的电刺激包括由脉冲宽度值和振幅值定义的多个脉冲。 脉冲幅度值增加（例如，手动），并且响应于以增加所施加的电刺激的强度的方式增加脉冲幅值来自动减小脉冲宽度值。 或者，可以减小脉冲宽度值（例如，手动地），并且响应于以增加所施加的电刺激的强度的方式减小脉冲宽度值，脉冲振幅值自动增加。