公开(公告)号：US09687204B2

公开(公告)日：2017-06-27

申请号：US13475048

申请日：2012-05-18

申请人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

发明人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

IPC分类号： A61B6/12 ,  A61B6/00 ,  A61B8/08 ,  A61B8/00 ,  A61B8/12

CPC分类号： A61B6/12 ,  A61B6/4417 ,  A61B6/4441 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4416 ,  A61B8/5261

摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

公开(公告)号：US20120230568A1

公开(公告)日：2012-09-13

申请号：US13412869

申请日：2012-03-06

申请人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Yang Wang ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Yefeng Zheng ,  Shaohua Kevin Zhou ,  Matthias John ,  Jan Boese

发明人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Yang Wang ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Yefeng Zheng ,  Shaohua Kevin Zhou ,  Matthias John ,  Jan Boese

IPC分类号： G06K9/36

CPC分类号： G06K9/6289 ,  G06K9/6211

摘要： A method and system for fusion of multi-modal volumetric images is disclosed. A first image acquired using a first imaging modality is received. A second image acquired using a second imaging modality is received. A model and of a target anatomical structure and a transformation are jointly estimated from the first and second images. The model represents a model of the target anatomical structure in the first image and the transformation projects a model of the target anatomical structure in the second image to the model in the first image. The first and second images can be fused based on estimated transformation.

摘要翻译： 公开了一种用于融合多模体积图像的方法和系统。 接收使用第一成像模式获取的第一图像。 接收使用第二成像模态获取的第二图像。 从第一和第二图像共同估计模型和目标解剖结构和变换。 该模型表示第一图像中目标解剖结构的模型，并且变换将第二图像中的目标解剖结构的模型投影到第一图像中的模型。 可以基于估计的变换来融合第一和第二图像。

公开(公告)号：US08177835B2

公开(公告)日：2012-05-15

申请号：US12545435

申请日：2009-08-21

申请人： Alois Noettling ,  Jan Boese ,  Matthias John ,  Volkmar Falk ,  Thomas Walther

发明人： Alois Noettling ,  Jan Boese ,  Matthias John ,  Volkmar Falk ,  Thomas Walther

IPC分类号： A61F2/24 ,  A61B5/05

CPC分类号： A61B6/032 ,  A61B6/503 ,  A61B8/0883 ,  A61F2/24

摘要： A method as a workflow for imaging for a heart valve implant procedure includes positioning the patient and an articulated imaging apparatus relative to one another, inducing rapid ventricular pacing in the patient, and imaging a region of the patient's heart to obtain image date for a three-dimensional image. The three-dimensional data is used to construct a three-dimensional image of the region of the patient's heart an the three-dimensional image is displayed for use in the implanting of the replacement heart valve. Optional steps may include obtaining a real time two-dimensional image of the patient's heart and superimposing the real time two-dimensional image with the constructed three dimensional image. The replacement valve is moved into position in the patient's heart during rapid ventricular pacing and breath hold using the superimposed two-dimensional and three-dimensional image information.

摘要翻译： 作为用于心脏瓣膜植入程序的成像工作流程的方法包括相对于彼此定位患者和关节成像装置，在患者体内引起快速心室起搏，以及对患者心脏的区域进行成像以获得三维图像的图像日期 维度图像。 三维数据用于构建患者心脏区域的三维图像，显示三维图像以用于置换心脏瓣膜的植入。 可选步骤可以包括获得患者心脏的实时二维图像，并且用构建的三维图像叠加实时二维图像。 使用重叠的二维和三维图像信息，在快速心室起搏和呼吸保持期间将置换瓣膜移动到患者心脏中的位置。

公开(公告)号：US08165839B2

公开(公告)日：2012-04-24

申请号：US12378003

申请日：2009-02-10

申请人： Jan Boese ,  Matthias John

发明人： Jan Boese ,  Matthias John

IPC分类号： G01D21/00 ,  G06F19/00

CPC分类号： A61B6/12 ,  A61B5/05 ,  A61B5/06 ,  A61B5/062 ,  A61B5/063 ,  A61B2560/0223

摘要： A method is proposed for calibrating an instrument location facility with an imaging apparatus. The instrument location apparatus and the imaging apparatus are synchronized temporally with one another. According to such synchronization at least three points of the position of a medical instrument relative to a tracking coordinate system of the instrument location apparatus and/or relative to an image coordinate system of the imaging apparatus are measured simultaneously both by the instrument location apparatus and by the imaging apparatus. The instrument and/or the imaging apparatus are moved relative to one another between the measurements. The measured points parameterize a predetermined transformation rule for mapping the tracking coordinate system onto the image coordinate system.

摘要翻译： 提出了一种利用成像装置校准仪器定位设备的方法。 仪器定位装置和成像装置在时间上彼此同步。 根据这样的同步，医疗仪器相对于仪器定位装置的跟踪坐标系和/或相对于成像装置的图像坐标系的位置的至少三个点同时由仪器定位装置和由仪器定位装置 成像装置。 仪器和/或成像设备在测量之间相对于彼此移动。 测量点参数化用于将跟踪坐标系映射到图像坐标系上的预定变换规则。

公开(公告)号：US20110164035A1

公开(公告)日：2011-07-07

申请号：US12984954

申请日：2011-01-05

申请人： Rui Liao ,  Ali Kamen ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Maria Lydia Sarmiento

发明人： Rui Liao ,  Ali Kamen ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Maria Lydia Sarmiento

IPC分类号： G06T15/00

CPC分类号： G06T7/0024 ,  A61B6/12 ,  A61B6/4266 ,  A61B6/481 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5264 ,  A61B6/541 ,  G06T7/246 ,  G06T7/30 ,  G06T7/33 ,  G06T2207/10072 ,  G06T2207/10121 ,  G06T2207/10124 ,  G06T2207/30048 ,  G06T2207/30101

摘要： A method (10) to compensate for cardiac and respiratory motion in cardiac imaging during minimal invasive (e.g., trans-catheter) AVI procedures by image-based tracking (20, 25) on fluoroscopic images.

摘要翻译： 一种用于通过基于图像的跟踪（20,25）在荧光镜图像上的最小侵入性（例如，跨导管）AVI过程中补偿心脏成像中的心脏和呼吸运动的方法（10）。

公开(公告)号：US20110052026A1

公开(公告)日：2011-03-03

申请号：US12858494

申请日：2010-08-18

申请人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Noettling ,  Jan Boese

发明人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Noettling ,  Jan Boese

IPC分类号： G06K9/00

CPC分类号： G06T7/73 ,  G06T2207/10116 ,  G06T2207/30052 ,  G06T2207/30101

摘要： A method and system for determining an angulation of a C-arm image acquisition system for aortic valve implantation is disclosed. One or more landmarks of the aortic root is detected in a 3D image. A plane representing an aortic annulus direction is defined in the 3D image based on the detected anatomic landmarks. A viewing angle is determined that is perpendicular to the defined plane.

摘要翻译： 公开了一种用于确定用于主动脉瓣植入的C臂图像采集系统的角度的方法和系统。 在3D图像中检测到主动脉根部的一个或多个标记。 基于检测到的解剖标志，在3D图像中定义代表主动脉环带方向的平面。 确定垂直于限定平面的视角。

公开(公告)号：US20080137924A1

公开(公告)日：2008-06-12

申请号：US11904583

申请日：2007-09-27

申请人： Jan Boese ,  Matthias John ,  Norbert Rahn

发明人： Jan Boese ,  Matthias John ,  Norbert Rahn

IPC分类号： G06K9/00

CPC分类号： G06T15/08 ,  G06T7/38 ,  G06T11/008 ,  G06T2207/10072

摘要： The invention relates to a device for merging a 2D radioscopy image with an image obtained from a 3D image data record, having a memory unit that stores the 2D radioscopy image and the 3D image data record, a segmentation unit that segments an inner surface of a hollow organ from the 3D image data record, a registration unit that registers the 2D radioscopy image with the 3D image data record, a back-projection unit that back-projects the pixels of the 2D radioscopy image onto the segmented surface, taking account of the projection geometry of the 2D radioscopy image and the registration, and an image merger unit that generates a virtual endoscopy view of the surface from the segmented surface using the back-projected pixels. The device primarily allows 2D radioscopy images to be superimposed during interventional procedures with a fly display of the interior of an interesting organ.

摘要翻译： 本发明涉及一种用于将2D放射线图像与从3D图像数据记录获得的图像合并的装置，具有存储2D放射线图像和3D图像数据记录的存储单元，分割单元，其将 来自3D图像数据记录的空心器官，将2D放射线图像与3D图像数据记录注册的登记单元，将2D放射线图像的像素反投影到分割表面上的背投影单元，考虑到 2D放射线图像的投影几何图像和配准，以及图像合并单元，其使用后投影像素从分割表面生成表面的虚拟内窥镜视图。 该装置主要允许在介入手术过程中叠加2D放射成像图像，并显示有趣器官内部的飞行显示。

公开(公告)号：US09036880B2

公开(公告)日：2015-05-19

申请号：US12797759

申请日：2010-06-10

申请人： Ulrich Hartung ,  Matthias John

发明人： Ulrich Hartung ,  Matthias John

IPC分类号： G06K9/00 ,  A61B6/03 ,  A61B6/00 ,  A61B8/08 ,  A61B5/00 ,  A61B6/12 ,  A61B8/00 ,  A61B19/00 ,  G01R33/48 ,  G01R33/563

CPC分类号： A61B6/032 ,  A61B5/7285 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/466 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5247 ,  A61B6/541 ,  A61B8/08 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/483 ,  A61B8/5238 ,  A61B8/543 ,  A61B2090/364 ,  G01R33/4808 ,  G01R33/56308

摘要： A computer-implemented method, a device, a system and a computer program are disclosed for three-dimensional displaying of medical body structures within the framework of a medical procedure, in particular cardiac surgery, wherein movement information is derived from a dynamic image of a body structure to be examined. In at least one embodiment, movement information is derived from vector analysis. After acquiring a static image of the respective body structure, vector analysis is applied to the static image to derive a modified static image with movement information of the body structure. The static image can then be displayed after it has moved.

摘要翻译： 公开了一种计算机实现的方法，装置，系统和计算机程序，用于在医疗程序，特别是心脏手术的框架内的医疗体结构的三维显示，其中运动信息是从动态图像 身体结构要检查。 在至少一个实施例中，从矢量分析导出运动信息。 在获取相应身体结构的静态图像之后，将矢量分析应用于静态图像，以获得具有身体结构的运动信息的修改的静态图像。 静态图像可以在移动后显示。

公开(公告)号：US08273870B2

公开(公告)日：2012-09-25

申请号：US13177316

申请日：2011-07-06

申请人： Roland Kreutzer ,  Stefan Limmer ,  Matthias John

发明人： Roland Kreutzer ,  Stefan Limmer ,  Matthias John

IPC分类号： C07H21/04

CPC分类号： C12N15/1131 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/50

摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.

摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区 突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。

公开(公告)号：US08077940B2

公开(公告)日：2011-12-13

申请号：US11725830

申请日：2007-03-20

申请人： Matthias John ,  Norbert Rahn

发明人： Matthias John ,  Norbert Rahn

IPC分类号： G06K9/00

CPC分类号： A61B8/12 ,  A61B5/0066 ,  A61B5/0456 ,  A61B8/543 ,  G06T11/005 ,  G06T2211/428

摘要： The invention relates to a method for reconstructing a three-dimensional target volume, particularly within the human body, in realtime and displaying it, with a three-dimensional reconstruction volume being determined from a basic set comprising a minimum number of two-dimensional images obtained from an image recording device located within the target volume, wherein, when a new image is included in the basic set, locally limited updating at least of the reconstruction volume's partial areas covered by the new image will under a predefined condition be performed and the updated reconstruction volume will be displayed.

摘要翻译： 本发明涉及一种用于重建三维目标体积，特别是在人体内实时地显示三维目标体积的方法，并且显示三维目标体积，其中三维重建体积是从包括最小数目的二维图像获得的基本集合确定的 从位于所述目标体积内的图像记录装置，其中，当在所述基本组中包括新图像时，在执行所述新图像所覆盖的至少所述重建体积的部分区域内的局部限制更新将被执行，并且所述更新 重建体积将被显示。