公开(公告)号：US4452575A

公开(公告)日：1984-06-05

申请号：US357734

申请日：1982-03-12

Applicant: (Lars) Lauritz B. Schibbye ,  Jan Johansson

Inventor： (Lars) Lauritz B. Schibbye ,  Jan Johansson

IPC: F04C29/04 ,  F01C1/16

CPC classification number: F04C29/042

Abstract: This invention relates to a method and a device for intermediate cooling in an oil-injected multi-stage screw compressor. Between the outlet (14) in one stage (10) and the inlet (16) in a subsequent stage (11) a connecting passageway (15) is located, through which the gas compressed in the firstmentioned stage (10) is supplied to the subsequent stage (11). For cooling the gas flowing out from the firstmentioned stage (10), in the connecting passageway (15) at least one nozzle (19) is located for the supply of a large cooling oil amount.

Abstract translation: 本发明涉及一种注油多级螺杆式压缩机中的中间冷却方法和装置。 在一级（10）中的出口（14）和后级（11）中的入口（16）之间设有连接通道（15），通过该连接通道（15）将在前述级（10）中压缩的气体供应到 后续阶段（11）。 为了冷却从第一级（10）流出的气体，在连接通道（15）中，设置有至少一个喷嘴（19）以供应大的冷却油量。

公开(公告)号：US09238058B2

公开(公告)日：2016-01-19

申请号：US13443164

申请日：2012-04-10

Applicant: Jan Johansson ,  Tore Curstedt ,  Joakim Robertson ,  Soeren Robertson ,  Magnus Robertson ,  Charlotte Robertson ,  Gertie Robertson Grossmann

Inventor： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson ,  Joakim Robertson ,  Soeren Robertson ,  Magnus Robertson ,  Charlotte Robertson ,  Gertie Robertson Grossmann

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/785

CPC classification number: A61K38/395 ,  A61K38/00 ,  C07K14/785

Abstract: Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders.

Abstract translation: 包含脂质载体，天然表面活性蛋白SP-C的多肽类似物和天然表面活性蛋白SP-B的多肽类似物的重构表面活性剂可用于治疗和/或预防RDS和其它呼吸系统疾病。

公开(公告)号：US20140010594A1

公开(公告)日：2014-01-09

申请号：US14024288

申请日：2013-09-11

Applicant: Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody

Inventor： Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody

IPC: E21D11/38

CPC classification number: F17C1/007 ,  E21B36/00 ,  E21D11/00 ,  E21D11/38 ,  E21D13/00 ,  F17C1/14 ,  F17C2201/0109 ,  F17C2201/0138 ,  F17C2201/019 ,  F17C2201/035 ,  F17C2201/037 ,  F17C2201/052 ,  F17C2203/0304 ,  F17C2203/0604 ,  F17C2203/0617 ,  F17C2203/0619 ,  F17C2203/0639 ,  F17C2203/0678 ,  F17C2205/0142 ,  F17C2221/031 ,  F17C2221/033 ,  F17C2223/0123 ,  F17C2223/035 ,  F17C2223/036 ,  F17C2227/0192 ,  F17C2260/046 ,  F17C2270/0581

Abstract: In various embodiments, lined underground reservoirs and/or insulated pipeline vessels are utilized for storage of compressed fluid in conjunction with energy storage and recovery systems.

Abstract translation: 在各种实施例中，使用衬里的地下储存器和/或绝缘管道容器用于与能量储存和回收系统一起存储压缩流体。

公开(公告)号：US20130123173A1

公开(公告)日：2013-05-16

申请号：US13643935

申请日：2011-04-28

Applicant: John K. Bielicki ,  Jan Johansson

Inventor： John K. Bielicki ,  Jan Johansson

IPC: C07K14/00 ,  A61K38/16

CPC classification number: C07K14/001 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00

Abstract: The present invention provides non-naturally occurring polypeptides that are oxidation resistant and have cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABACI that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation; and diagnostic methods employing the peptides to evaluated cholesterol efflux activity.

Abstract translation: 本发明提供了抗天然存在的多肽，其具有与全长载脂蛋白（例如Apo AI和Apo E）相似的胆固醇流出活性，并且对于与全长载脂蛋白的ABACI平行的ABACI具有高选择性 。 本发明还提供包含这种多肽的组合物，鉴定，筛选和合成这些多肽的方法，治疗，预防或诊断与血脂异常，高胆固醇血症和炎症相关的疾病和病症的方法; 以及采用该肽评估胆固醇流出活性的诊断方法。

公开(公告)号：US08415293B2

公开(公告)日：2013-04-09

申请号：US12999966

申请日：2009-06-17

Applicant: John K. Bielicki ,  Jan Johansson

Inventor： John K. Bielicki ,  Jan Johansson

IPC: A61K38/10 ,  A61P9/10

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/00

Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

Abstract translation: 本发明提供了一种非天然存在的多肽，其具有与全长载脂蛋白（例如Apo AI和Apo E）相似的胆固醇流出活性，并且对于与全长载脂蛋白的ABAC1平行的ABAC1具有高选择性。 本发明还提供包含这些多肽的组合物，鉴定，筛选和合成这些多肽的方法，以及治疗，预防或诊断与血脂异常，高胆固醇血症和炎症相关的疾病和病症的方法。

公开(公告)号：US08278416B1

公开(公告)日：2012-10-02

申请号：US13441118

申请日：2012-04-06

Applicant: Jan Johansson ,  Göran Hjälm ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

Inventor： Jan Johansson ,  Göran Hjälm ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

IPC: C07K1/00 ,  C07K14/00

CPC classification number: C07K14/43518 ,  A61K35/12 ,  A61K47/42 ,  D01F4/00

Abstract: The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.

Abstract translation: 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式REP-CT定义。 REP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。

公开(公告)号：US08148492B2

公开(公告)日：2012-04-03

申请号：US12222517

申请日：2008-08-11

Applicant: Jan Johansson ,  Tore Curstedt ,  Bengt Robertson ,  Maurlzio Delcanale

Inventor： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson ,  Maurlzio Delcanale

IPC: C07K14/00

CPC classification number: C07K14/785 ,  A61K38/00

Abstract: The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to a use thereof in the treatment or prophylaxis of RDS and other respiratory disorders.

Abstract translation: 本发明涉及包含脂质载体，天然表面活性蛋白SP-C的多肽类似物和天然表面活性蛋白SP-B的多肽类似物的重构表面活性剂。 本发明还涉及其药物组合物及其在治疗或预防RDS和其它呼吸系统疾病中的用途。

公开(公告)号：US20120041177A1

公开(公告)日：2012-02-16

申请号：US13264938

申请日：2010-04-21

Applicant: Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

Inventor： Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

IPC: C07K14/435 ,  C12P21/00 ,  C07K1/14

CPC classification number: C07K14/43518

Abstract: A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerisation of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerisation of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider silk protein polymers are isolated from the liquid medium. The resulting polymers are useful as fibers, films, foams, nets or meshes.

Abstract translation: 制备分离的蜘蛛丝蛋白的聚合物的方法包括提供所述蜘蛛丝蛋白在pH6.4或更高的液体培养基中的溶液和/或防止蜘蛛丝蛋白聚合的离子组合物。 将液体介质的性质调节至6.3或更低的pH，以及允许蜘蛛丝蛋白质聚合的离子组合物。 允许蜘蛛丝蛋白在液体培养基中形成聚合物，并且从液体培养基中分离得到的蜘蛛丝蛋白聚合物。 所得聚合物可用作纤维，薄膜，泡沫，网或网。

公开(公告)号：US07972091B2

公开(公告)日：2011-07-05

申请号：US11661325

申请日：2005-09-02

Applicant: Inge Svenningsson ,  Mikael Lundblad ,  Jan Johansson ,  Magnus Åström ,  David Öhlund

Inventor： Inge Svenningsson ,  Mikael Lundblad ,  Jan Johansson ,  Magnus Åström ,  David Öhlund

IPC: B23P15/28

CPC classification number: B23C5/207 ,  B23C5/10 ,  B23C5/109 ,  B23C2200/125 ,  B23C2200/165 ,  B23C2210/0407 ,  B23C2210/0442 ,  B23C2210/084 ,  B23C2210/126 ,  Y10T407/1938 ,  Y10T407/1946 ,  Y10T407/1948 ,  Y10T407/23 ,  Y10T407/235 ,  Y10T407/245

Abstract: A milling tool intended for chip-removing machining includes a basic body rotatable around a geometrical centre axis and peripherically spaced-apart, detachable cutting inserts, which separately are securable in insert pockets adjacent to chip channels formed in the basic body. The individual cutting insert have at least one edge formed between a chip surface on the top side of the cutting insert and a clearance surface along the periphery side of the cutting insert, and the individual insert pocket is arranged to secure the individual cutting insert in a position in which the chip surface is inclined in relation to the centre axis while forming a positive angle of inclination.

Abstract translation: 用于去屑加工的铣削工具包括可围绕几何中心轴线旋转的基本主体和外围间隔开的可拆卸的切削刀片，所述切削刀片在与形成在基体中的切屑通道相邻的刀片槽中分开固定。 单独的切削刀片具有形成在切削刀片的顶侧上的切屑表面和沿着切削刀片的周边侧的间隙表面之间的至少一个边缘，并且单个刀片槽被布置成将单独的切削刀片固定在 芯片表面相对于中心轴线倾斜同时形成正的倾斜角度的位置。

公开(公告)号：US20110057169A1

公开(公告)日：2011-03-10

申请号：US12991891

申请日：2009-09-03

Applicant: Richard G. Harris ,  Andrew J. Berkley ,  Jan Johansson ,  Mark Johnson ,  Mohammad Amin ,  Paul I. Bunyk

Inventor： Richard G. Harris ,  Andrew J. Berkley ,  Jan Johansson ,  Mark Johnson ,  Mohammad Amin ,  Paul I. Bunyk

IPC: H01L39/22 ,  B82Y10/00

CPC classification number: H01L39/223 ,  B82Y10/00 ,  G06N99/002 ,  H01L27/18

Abstract: Apparatus and methods enable active compensation for unwanted discrepancies in the superconducting elements of quantum processor. A qubit may include a primary compound Josephson junction (CJJ) structure, which may include at least a first secondary CJJ structure to enable compensation for Josephson junction asymmetry in the primary CJJ structure. A qubit may include a series LC-circuit coupled in parallel with a first CJJ structure to provide a tunable capacitance. A qubit control system may include means for tuning inductance of a qubit loop, for instance a tunable coupler inductively coupled to the qubit loop and controlled by a programming interface, or a CJJ structure coupled in series with the qubit loop and controlled by a programming interface.

Abstract translation: 装置和方法能够对量子处理器的超导元件中的有害偏差进行有效补偿。 量子位可以包括主复合约瑟夫逊结（CJJ）结构，其可以包括至少第一次级CJJ结构，以能够补偿主CJJ结构中的约瑟夫逊结不对称性。 量子位可以包括与第一CJJ结构并联耦合以提供可调电容的串联LC电路。 量子位控制系统可以包括用于调整量子位环路的电感的装置，例如感应耦合到量子位循环并由编程接口控制的可调谐耦合器件，或与量子位循环串联耦合并由编程接口控制的CJJ结构 。